Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer

Shastri, Anuradha; Lombardo, Joseph; Okere, Samantha; Higgins, Stéphanie; Smith, Brittany C.; DeAngelis, Tiziana; Palagani, Ajay; Hines, Kamryn; Monti, Daniel; Volpe, Stella L.; Mitchell, Edith P.; Simone, Nicole L.

doi:10.3390/ijms23010175

Cited by 7 publications

(3 citation statements)

References 116 publications

(124 reference statements)

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“…However, due to the damage to the human immune system after treatment, as well as the depression of patients, it will inevitably lead to insufficient nutritional intake of patients. Persistent nutritional deficiencies can further affect recovery and treatment [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Chinese Herbal Formula on Immune Function and Nutritional Status of Breast Cancer Patients

Liu

2022

Computational and Mathematical Methods in Medicine

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Background. Chinese herbal formulas have certain effects on patients with breast cancer (BC). This article discussed the effect of Buqi Yangxue decoction on the immune function and nutritional status of BC patients and provided an evidence for traditional Chinese medicine (TCM) to improve the quality of life and curative effect of BC patients. Methods. 66 cases of BC patients were divided into control group (n =33) and Chinese herbal formula group (n =33). The control group was received with TE chemotherapy, and the Chinese herbal formula group was received with Buqi Yangxue decoction combined with TE chemotherapy. Nutritional status, immune function, TCM symptom quantitative score, and adverse reactions were compared between the two groups. Results. There was no difference in all indexes between the two groups before intervention. After 4 weeks, the nutritional indexes ALB, PA, TRF, and TP in Chinese herbal formula group were higher than those in control group, except HGb. CD3+, CD4+, and CD4+/CD8+ in both groups were sharply higher than before treatment, while CD8+ was dramatically lower, and the changes in Chinese herbal formula group were more obvious than those in control group. In Chinese herbal formula group, the levels of IgG, IgA, and IgM were sharply increased compared with control group. The TCM syndrome scores in both groups were decreased significantly after treatment, especially in Chinese herbal formula group. In addition, nausea and vomiting, inappetence, liver function impairment, leukopenia, and thrombocytopenia occurred in both groups. There was no clear difference in the incidence of adverse reactions between Chinese herbal formula group and control group. Conclusion. Buqi Yangxue decoction can effectively improve the nutritional status and immune function of BC patients, which has important clinical significance for the later comprehensive treatment.

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Section: Introductionmentioning

confidence: 99%

Effects of Chinese Herbal Formula on Immune Function and Nutritional Status of Breast Cancer Patients

Liu

2022

Computational and Mathematical Methods in Medicine

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“…In recent years, the literature has indicated that impaired nutritional status may affect tolerance to surgery and the prognosis of patients with various types of cancer. [3][4][5] In this context, the Controlling Nutritional Status (CONUT) score was developed by Ignacio de Ulíbarri et al [6] for screening the preoperative nutritional status. This index was calculated based on the preoperative serum albumin concentration, total peripheral blood lymphocyte count, and total cholesterol concentration (Supplementary Table S1, http://links.lww.com/CURRUROL/A46).…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of Controlling Nutritional Status score for postoperative complications and biochemical recurrence in prostate cancer patients undergoing laparoscopic radical prostatectomy

Xiong,

Ye,

Zhu

et al. 2024

Curr Urol

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Background The correlation between the Controlling Nutritional Status (CONUT) score and the prognosis of patients with prostate cancer (PCa) has yet to be elucidated. Herein, we analyzed the prognostic value of CONUT scores in patients with PCa who underwent laparoscopic radical prostatectomy. Materials and methods Data of 244 patients were retrospectively evaluated. Perioperative variables and follow-up data were analyzed. The patients were categorized into 2 groups according to their preoperative CONUT scores. Postoperative complication and incontinence rates were also compared. The Kaplan-Meier method was used to estimate the median biochemical recurrence-free survival (BCRFS) between the 2 groups. Univariate and multivariate Cox regression analyses were performed to identify the potential prognostic factors for BCRFS. Results Patients were categorized into the low-CONUT group (CONUT score <3, n = 207) and high-CONUT group (CONUT score ≥3, n = 37). The high-CONUT group had a higher overall complication rate (40.5% vs.19.3%, p = 0.004), a higher major complication rate (10.8% vs. 3.9%, p = 0.013), and longer postoperative length of stay (8 days vs. 7 days, p = 0.017). More fever, urinary infection, abdominal infection, scrotal edema, rash, and hemorrhagic events (all p values < 0.05) were observed in the high-CONUT group. A higher rate of urinary incontinence was observed in the high-CONUT group at 1 (34.4% vs. 13.2%, p = 0.030) and 3 months (24.1% vs. 8.2%, p = 0.023) postoperatively. The high-CONUT group had shorter medium BCRFS (23.8 months vs. 54.6 months, p = 0.029), and a CONUT score ≥3 was an independent risk factor for a shorter BCRFS (hazards ratio, 1.842; p = 0.026). Conclusions The CONUT score is a useful predictive tool for higher postoperative complication rates and shorter BCRFS in patients with PCa who undergo laparoscopic radical prostatectomy.

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“…Several clinical trials have been carried out, and many are now undertaken to come up with a significant upshot conclusion based on primary and secondary outcomes to show the after-effects of particular nutrient supplements by increasing the overall survival or any other physiological upregulated/downregulated manifestation leading to diseasefree survival (Swaminathan, 2020). Understanding metabolic and immune regulation inherent to patient populations is key to improving the radiation response for breast cancer patients (Shastri et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Personalized Nutrition Intervention In Breast Cancer Patients: A Systematic Review

Puspa Anindita Sidharta

2023

JMI

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Breast cancer is a common cancer in women worldwide. Personalized nutrition interventions have gained attention as a promising approach in the treatment of breast cancer. This systematic review aimed to evaluate their effectiveness. A comprehensive search of ScienceDirect and PubMed databases was conducted from 2018 to 2023 using the keyword "Personalized nutrition interventions for breast cancer." Six studies met the inclusion criteria. Results showed that dietary interventions led to improvements in body weight, metabolic parameters, and quality of life in breast cancer patients. The Mediterranean diet was associated with significant improvements in body weight, BMI, waist circumference, glycemia, and triglyceride levels, as well as a greater reduction in metabolic syndrome markers. The ketogenic diet resulted in significant weight loss due to fat mass reduction, while personalized and balanced diet interventions reduced the frequency of leukopenia and abdominal pain. A triple intervention program involving nutrition, exercise, and mindfulness positively impacted the quality of life in breast cancer survivors. Individualized diet therapy based on nutritional needs also significantly reduced barriers and improved nutritional status and quality of life in breast cancer patients undergoing chemotherapy. This review employed a systematic approach, including a comprehensive literature search, clear inclusion criteria, and thorough study quality assessment. In conclusion, personalized nutrition interventions can be effective for improving outcomes in breast cancer patients.

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Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer

Cited by 7 publications

References 116 publications

Effects of Chinese Herbal Formula on Immune Function and Nutritional Status of Breast Cancer Patients

Effects of Chinese Herbal Formula on Immune Function and Nutritional Status of Breast Cancer Patients

Prognostic value of Controlling Nutritional Status score for postoperative complications and biochemical recurrence in prostate cancer patients undergoing laparoscopic radical prostatectomy

The Effects of Personalized Nutrition Intervention In Breast Cancer Patients: A Systematic Review

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