Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation

Fabozzi, Gemma; Verdone, Giulia; Allori, Mariachiara; Cimadomo, Danilo; Tatone, Carla; Stuppia, Liborio; Franzago, Marica; Ubaldi, Nicolò; Vaiarelli, Alberto; Ubaldi, Filippo Maria; Rienzi, Laura; Gennarelli, Gianluca

doi:10.3390/nu14091918

Cited by 32 publications

(37 citation statements)

References 455 publications

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“…Chronic low-grade inflammation has been widely recognized as a pathogenesis factor in a wide array of highly detrimental pathophysiological conditions such as auto-immune, cancerous, cardiovascular, metabolic, musculoskeletal, neurodegenerative, psychosomatic, reproductive, dermatological, and other disorders [ 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 ]. BP encompasses marked inhibitory activities on inflammations including systemic and localized forms such as neuroinflammation and digestive wall inflammations [ 65 ].…”

Section: Resultsmentioning

confidence: 99%

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Kacemi,

Campos

2023

Nutrients

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The emphasis on healthy nutrition is gaining a forefront place in current biomedical sciences. Nutritional deficiencies and imbalances have been widely demonstrated to be involved in the genesis and development of many world-scale public health burdens, such as metabolic and cardiovascular diseases. In recent years, bee pollen is emerging as a scientifically validated candidate, which can help diminish conditions through nutritional interventions. This matrix is being extensively studied, and has proven to be a very rich and well-balanced nutrient pool. In this work, we reviewed the available evidence on the interest in bee pollen as a nutrient source. We mainly focused on bee pollen richness in nutrients and its possible roles in the main pathophysiological processes that are directly linked to nutritional imbalances. This scoping review analyzed scientific works published in the last four years, focusing on the clearest inferences and perspectives to translate cumulated experimental and preclinical evidence into clinically relevant insights. The promising uses of bee pollen for malnutrition, digestive health, metabolic disorders, and other bioactivities which could be helpful to readjust homeostasis (as it is also true in the case of anti-inflammatory or anti-oxidant needs), as well as the benefits on cardiovascular diseases, were identified. The current knowledge gaps were identified, along with the practical challenges that hinder the establishment and fructification of these uses. A complete data collection made with a major range of botanical species allows more robust clinical information.

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Section: Resultsmentioning

confidence: 99%

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Kacemi,

Campos

2023

Nutrients

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“…Increasing evidence showed the important role of nutrition in reproduction, especially female fertility. 7 Selenium is an essential trace element for life and is an important dietary antioxidant. 8 Selenium was previously identified to affect the growth and proliferation of follicles through antioxidant effects.…”

Section: Introductionmentioning

confidence: 99%

“…Increasing evidence showed the important role of nutrition in reproduction, especially female fertility 7 . Selenium is an essential trace element for life and is an important dietary antioxidant 8 .…”

Section: Introductionmentioning

confidence: 99%

The moderating effect of dietary selenium intake on the risk of infertility‐associated depressive symptoms in female

Wang,

Xiao,

2024

J of Obstet and Gynaecol

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AimTo analyze the associations between infertility or dietary selenium intake and depressive symptoms as well as the role of selenium intake on the association between infertility and depressive symptoms in women.MethodsThis study retrieved the data of 4949 women from National Health and Nutrition Examination Survey (NHANES) database. Univariable and multivariable weighted logistic regression analyses were applied to assess the associations of selenium intake or infertility with the risk of depressive symptoms as well as the regulation of selenium intake on the risk of depressive symptoms related to infertility.ResultsThe elevated risk of depressive symptoms was found in participants with infertility (odds ratio [OR] = 1.54, 95% confidence interval [CI]: 1.11–2.15). The risk of depressive symptoms was reduced in women with selenium intake ≥55 μg (OR = 0.64, 95%CI: 0.46–0.90). Compared with women without infertility who had selenium intake <55 μg, those with infertility and had selenium intake <55 μg were associated with elevated risk of depressive symptoms after adjusting for confounding factors (OR = 2.01, 95%CI: 1.03–3.90). The risk of depressive symptoms was not significantly increased in women with infertility who had selenium intake ≥55 μg in comparison with subjects without infertility who had selenium intake ≥55 μg (p > 0.05).ConclusionSelenium intake regulated the association between infertility and depressive symptoms.

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“…There is mounting evidence that certain infertility-related illnesses are linked to longterm inflammatory illnesses. 4 The inflammatory response is simultaneously influenced by a number of reproductive events, including ovulation, menstrual production, placenta production and implantation, and pregnancy. [5][6][7][8] It is vital to investigate how the inflammatory response contributes to the etiology of infertility.…”

Section: Introductionmentioning

confidence: 99%

“…Figure4 Association between NLR and PLR in the High-BMI group study population (mmol/L). Figure4shows the smooth fitting curve of NLR and PLR.…”

mentioning

confidence: 99%

Inflammatory Markers in Women with Infertility: A Cross-Sectional Study

Duan¹,

Zhou²,

Peng³

et al. 2023

IJGM

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Infertility is highly correlated with inflammation. We sought to evaluate the independent relationships between each inflammatory marker in women with infertility. Patients and Methods: This cross-sectional study included 1028 infertile patients who were hospitalized at Jining Medical University between January 2016 and December 2022. NLR and PLR were the independent and dependent variables measured at baseline, respectively. Age, body mass index (BMI), and menstrual status were covariates. Based on BMI, the study population was split into two groups: Low-BMI and High-BMI. Results: A stratified analysis revealed that the overweight group had significantly higher levels of WBC, platelet count, lymphocyte count, neutrophil count and NLR. Comparing the overweight group to the normal weight group, the levels were noticeably higher in the overweight group. Significantly positive correlations between NLR and PLR were found in both univariate and multiple regression analyses. Conclusion:There was a significant positive correlation between NLR and PLR in infertility patients. These results will help in the search for biomarkers of infertility and in the development of infertility prediction models.

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Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation

Cited by 32 publications

References 455 publications

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

The moderating effect of dietary selenium intake on the risk of infertility‐associated depressive symptoms in female

Inflammatory Markers in Women with Infertility: A Cross-Sectional Study

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