Personalized redox biology: Designs and concepts

Margaritelis, Nikos V.

doi:10.1016/j.freeradbiomed.2023.08.003

Cited by 6 publications

(3 citation statements)

References 118 publications

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“…It's important to note that genetic modification (gene doping) and illegal supplement use are beyond the scope of this approach, as they are prohibited and unethical practices in sports (85). Lastly, acknowledging potential challenges in interpreting personalized interventions using clinical, physiological, and biomedical information, refining methodologies on data analysis will be key to overcoming these obstacles (86)(87)(88)(89).…”

Section: Discussionmentioning

confidence: 99%

Advancing athletic assessment by integrating conventional methods with cutting-edge biomedical technologies for comprehensive performance, wellness, and longevity insights

Spanakis,

Fragkiadaki,

Renieri

et al. 2024

Front. Sports Act. Living

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In modern athlete assessment, the integration of conventional biochemical and ergophysiologic monitoring with innovative methods like telomere analysis, genotyping/phenotypic profiling, and metabolomics has the potential to offer a comprehensive understanding of athletes' performance and potential longevity. Telomeres provide insights into cellular functioning, aging, and adaptation and elucidate the effects of training on cellular health. Genotype/phenotype analysis explores genetic variations associated with athletic performance, injury predisposition, and recovery needs, enabling personalization of training plans and interventions. Metabolomics especially focusing on low-molecular weight metabolites, reveal metabolic pathways and responses to exercise. Biochemical tests assess key biomarkers related to energy metabolism, inflammation, and recovery. Essential elements depict the micronutrient status of the individual, which is critical for optimal performance. Echocardiography provides detailed monitoring of cardiac structure and function, while burnout testing evaluates psychological stress, fatigue, and readiness for optimal performance. By integrating this scientific testing battery, a multidimensional understanding of athlete health status can be achieved, leading to personalized interventions in training, nutrition, supplementation, injury prevention, and mental wellness support. This scientifically rigorous approach hereby presented holds significant potential for improving athletic performance and longevity through evidence-based, individualized interventions, contributing to advances in the field of sports performance optimization.

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Section: Discussionmentioning

confidence: 99%

Advancing athletic assessment by integrating conventional methods with cutting-edge biomedical technologies for comprehensive performance, wellness, and longevity insights

Spanakis,

Fragkiadaki,

Renieri

et al. 2024

Front. Sports Act. Living

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show abstract

“…Based on the pioneering insights of Nikolaidis [ 108 , 109 ], Margaritelis [ 110 ] and others [ 110 ], the third age of redox research is set to witness the rise of personalised redox biology. Given understanding of redox heterogeneity is emerging, the discussion will necessarily be brief.…”

Section: Part 2 the Evidencementioning

confidence: 99%

50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis

Cobley

2023

Redox Biology

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“…They can also address lingering questions in redox signalling (Fuentes-Lemus and Glover et al, 2023;Henriquez-Olguin et al, 2023), particularly around the spatial regulation of the process with the potential for phase transition effects (Dai et al, 2023;Kritsiligkou et al, 2023). Finally, the field is set to play a leading role in unravelling the addressing individuality at the dawn of the personalised redox biology era (Margaritelis, 2023). For example, potential differences in exercise-induced oxidative stress manifests in males compared to remain largely unexplored.…”

mentioning

confidence: 99%

Ten “Cheat Codes” for Measuring Oxidative Stress in Humans

Cobley,

Margaritelis,

Chatzinikolaou

et al. 2024

Preprint

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Formidable and often seemingly insurmountable conceptual, technical, and methodological challenges hamper the measurement of oxidative stress in humans. For instance, fraught and flawed methods, such as the thiobarbituric acid reactive substances assay kits for lipid peroxidation, rate-limit progress. To advance translational redox research, we present ten comprehensive “cheat codes” for measuring oxidative stress in humans. The cheat codes include analytical approaches to assess reactive oxygen species, antioxidants, biomarkers of oxidative damage and redox regulation. They provide essential conceptual, technical, and methodological information inclusive of curated “do” and “don’t” guidelines. Given the biochemical complexity of oxidative stress, we present a research question-grounded decision tree guide for selecting the most appropriate cheat code (s) to implement in a prospective human experiment. Worked examples demonstrate the benefits of the decision tree-based cheat code selection tool. The ten cheat codes define an invaluable resource for measuring oxidative stress in humans.

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Personalized redox biology: Designs and concepts

Cited by 6 publications

References 118 publications

Advancing athletic assessment by integrating conventional methods with cutting-edge biomedical technologies for comprehensive performance, wellness, and longevity insights

Advancing athletic assessment by integrating conventional methods with cutting-edge biomedical technologies for comprehensive performance, wellness, and longevity insights

50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis

Ten “Cheat Codes” for Measuring Oxidative Stress in Humans

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