Personalized repetitive transcranial magnetic stimulation (prtms®) for post-traumatic stress disorder (ptsd) in military combat veterans

Makale, Milan T.; Abbasi, Shaghayegh; Nybo, Chad; Keifer, Jason; Christman, Lori; Fairchild, J. Kaci; Yesavage, Jerome; Blum, Kenneth; Gold, Mark S.; Baron, David; Cadet, Jean Lud; Elman, Igor; Dennen, Catherine A.; Murphy, Kevin T.

doi:10.1016/j.heliyon.2023.e18943

Cited by 7 publications

(2 citation statements)

References 111 publications

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“…Challenges identified in clinical studies examining efficacy of these therapies include issues with engagement and early drop-out rates ( 71 ), which may be improved by facilitating access to technology-based delivery or with combined efficacious pharmacotherapy ( 70 , 72 ). In recent years, non-invasive brain stimulation techniques, including repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), have demonstrated benefits in PTSD treatment ( 73 – 76 ). Whereas tDCS involves introducing low-intensity electric currents through the skull, rTMS involves repeated and rapidly changing electric currents on the surface of the skull.…”

Section: Observationsmentioning

confidence: 99%

“…Whereas tDCS involves introducing low-intensity electric currents through the skull, rTMS involves repeated and rapidly changing electric currents on the surface of the skull. Both rTMS and tDCS have been shown to modulate cortical excitability in the brain ( 76 , 77 ), and can improve PTSD symptoms, either as a monotherapy or as a treatment enhancement strategy with minimal side effects ( 73 , 74 , 78 ). However, data relating to treatment effects in PTSD are limited, and studies to clarify the exact mechanisms of action of tDCS and rTMS are warranted ( 75 , 78 ).…”

Section: Observationsmentioning

confidence: 99%

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Post-traumatic stress disorder: the role of the amygdala and potential therapeutic interventions – a review

Davis,

Hamner

2024

Front. Psychiatry

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IntroductionPost-traumatic stress disorder (PTSD) is a psychiatric disorder triggered by exposure to a life-threatening or sexually violent traumatic event, and is characterized by symptoms involving intrusive re-experiencing, persistent avoidance of associated stimuli, emotional and cognitive disturbances, and hyperarousal for long periods after the trauma has occurred. These debilitating symptoms induce occupational and social impairments that contribute to a significant clinical burden for PTSD patients, and substantial socioeconomic costs, reaching approximately $20,000 dollars per individual with PTSD each year in the US. Despite increased translational research focus in the field of PTSD, the development of novel, effective pharmacotherapies for its treatment remains an important unmet clinical need.ObservationsIn this review, we summarize the evidence implicating dysfunctional activity of the amygdala in the pathophysiology of PTSD. We identify the transient receptor potential canonical (TRPC) ion channels as promising drug targets given their distribution in the amygdala, and evidence from animal studies demonstrating their role in fear response modulation. We discuss the evidence-based pharmacotherapy and psychotherapy treatment approaches for PTSD.DiscussionIn view of the prevalence and economic burden associated with PTSD, further investigation is warranted into novel treatment approaches based on our knowledge of the involvement of brain circuitry and the role of the amygdala in PTSD, as well as the potential added value of combined pharmacotherapy and psychotherapy to better manage PTSD symptoms.

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