Personalizing prognostic prediction in early-onset Colorectal Cancer

Liu, Jian; Liu, Zhengru; Li, Jiao; Tian, Shan; Dong, Weiguo

doi:10.7150/jca.46871

Cited by 10 publications

(8 citation statements)

References 38 publications

(50 reference statements)

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“…Our study demonstrated that sex had a minor influence on prognosis. These results are in accord with three studies ( 20 , 22 , 25 ) indicating that male EO-CRC patients exhibited slightly poorer survival compared to their female counterparts. However, several studies ( 13 , 15 , 16 , 18 , 19 , 24 ) indicated that sex was not a significant prognostic factor for the survival of EO-CRC patients.…”

Section: Discussionsupporting

confidence: 92%

Construction and validation of a nomogram for predicting overall survival of patients with stage III/IV early−onset colorectal cancer

Yin,

Pei,

et al. 2024

Front. Oncol.

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PurposeThis study aimed to identify prognostic factors and develop a nomogram for predicting overall survival (OS) in stage III/IV early-onset colorectal cancer (EO-CRC).MethodsStage III/IV EO-CRC patients were identified from the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2015. The datasets were randomly divided (2:1) into training and validation sets. A nomogram predicting OS was developed based on the prognostic factors identified by Cox regression analysis in the training cohort. Moreover, the predictive performance of the nomogram was assessed using the receiver operating characteristic (ROC) curves, calibration plots, and decision curve analysis (DCA). Subsequently, the internal validation was performed using the validation cohort. Finally, a risk stratification system was established based on the constructed nomogram.ResultsOf the 10,387 patients diagnosed with stage III/IV EO-CRC between 2010 and 2015 in the SEER database, 8,130 patients were included. In the training cohort (n=3,071), sex, marital status, race/ethnicity, primary site, histologic subtypes, grade, T stage, and N stage were identified as independent prognostic variables for OS. The 1-, 3-, and 5-year area under the curve (AUC) values of the nomogram were robust in both the training (0.751, 0.739, and 0.723) and validation cohorts (0.748, 0.733, and 0.720). ROC, calibration plots, and DCA indicated good predictive performance of the nomogram in both the training and validation sets. Furthermore, patients were categorized into low-, middle-, and high-risk groups based on the nomogram risk score. Kaplan-Meier curve showed significant survival differences between the three groups.ConclusionWe developed a prognostic nomogram and risk stratification system for stage III/IV EO-CRC, which may facilitate clinical decision-making and individual prognosis prediction.

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Section: Discussionsupporting

confidence: 92%

Construction and validation of a nomogram for predicting overall survival of patients with stage III/IV early−onset colorectal cancer

Yin,

Pei,

et al. 2024

Front. Oncol.

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“…2 The 5-year overall survival rate for PNETs in early stages are 61.9%, and the 5year survival rate for advanced cancers is less than 20%. 3 Previous studies have found that there are differences in clinical characteristics and prognosis between young and old in cancer patients including lung cancer, 4 colorectal cancer, 5 and so on. PNETs is a kind of highly heterogeneous tumor, however, the clinical characteristics and prognosis of young patients with PNETs had not been well studied.…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics and Prognostic Factors of Early-Onset Pancreatic Neuroendocrine Tumors

Shi¹,

Zhou²

2021

Cancer Control

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Background: The incidence of pancreatic neuroendocrine tumors (PNETs) has increased significantly. The purpose of this study was to analyze the clinical characteristics and prognosis of patients under 50 years old. Methods: Patients with PNETs recorded in the Surveillance, Epidemiology, and End Results (SEER) database from 2004 to 2015 were analyzed. The clinical characteristics were analyzed by Chi-square test. The Kaplan-Meier method was used to estimate overall survival (OS). Multivariate Cox proportional risk regression analysis was used to determine independent prognostic factors. Results: 2,303 patients included, of which 547 (23.8%) patients were younger than 50 years old. The number of younger patients has increased steadily, while the proportion in total PNETs decreased recently. Compared with older group, the proportion of the Black, grade I/II, and surgery were higher in early-onset PNETs. Liver was the most frequent metastatic site. There was no significant difference in the incidence of different metastatic sites between younger and older PNETs patients, while younger patients had better OS (P < 0.05). Grade, N stage, M stage, and surgery were independent prognostic factors for OS in early-onset PNETs. Conclusions: Younger patients have unique clinicopathological characteristics compared with older patients in PNETs. Better OS was observed in younger patients which might due to the higher proportion of well-differentiated tumor and surgery than older patients.

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“…SUMOylation of METTL3 regulating its m 6 A RNA methyltransferase activity (Du et al , 2018). Liu et al (2019) found that high METTL3 expression and decreased regulation of METTL14, FTO and ALKBH5 were positively correlated with poor prognosis in colorectal cancer (CRC) patients.…”

Section: Discussionmentioning

confidence: 99%

“…Accumulating evidence have supported the fact that the m 6 A RNA methylation impact the initiation and progression of human cancers through diverse mechanisms, such as acute myeloid leukemia, bile duct carcinoma, glioblastomas and hepatocellular carcinoma (Dai et al , 2018; Jaffrey et al , 2017; Wang et al , 2017). The m 6 A modification is reversible and dynamic, involving adenosine methyltransferases (m 6 A writers), RNA-binding proteins (m 6 A readers) and demethylases (m 6 A erasers), which can add, recognize or remove m 6 A-modified sites and alter important biological processes accordingly (Pinello et al , 2018; Liu et al , 2019).…”

Section: Introductionmentioning

confidence: 99%

Gene and prognostic value of N6-methyladenosine (m6A) modification regulatory factors in lung adenocarcinoma

Zhang

Wang

et al. 2021

European Journal of Cancer Prevention

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Lung cancer is the leading cause of death worldwide, and its incidence continues to increase. The treatment of lung cancer is related to the subtypes and stages of cancer, but the therapeutic effect is still unsatisfactory. We found that 10 of the 13 genes were differentially expressed in lung cancer, YTHDF1, RBM15, HNRNPC, KIAA1429, METTL3 and YTHDF2 are high expression while METTL14, ZC3H13, FTO and WTAP are low expression. HNRNPC and METTL3 genes were associated with the risk and prognosis of LUAD and could regard as biomarkers for early diagnosis and treatment, which provides a theoretical basis for LUAD.

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Personalizing prognostic prediction in early-onset Colorectal Cancer

Cited by 10 publications

References 38 publications

Construction and validation of a nomogram for predicting overall survival of patients with stage III/IV early−onset colorectal cancer

Construction and validation of a nomogram for predicting overall survival of patients with stage III/IV early−onset colorectal cancer

Clinical Characteristics and Prognostic Factors of Early-Onset Pancreatic Neuroendocrine Tumors

Gene and prognostic value of N6-methyladenosine (m6A) modification regulatory factors in lung adenocarcinoma

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