Immunosuppression and Immunomodulation 2023
DOI: 10.5772/intechopen.108426
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Perspective Chapter: Engineering Secretory IgA against Infectious Diseases

Nicole Falci Finardi,
Audrey Y-H. Teh,
Julian K-C. Ma

Abstract: The dawn of antibody therapy was heralded by the rise of IgG therapeutics. However, other antibody classes are at our disposal—one of the most exciting is IgA and is the most abundant antibody class within humans. Unlike IgG, it is uniquely specialized for mucosal applications due to its ability to form complex Secretory IgA (SIgA) molecules. Since the mucosa is constantly exposed to potential infectious agents, SIgA is pivotal to disease prevention as an important component of the mucosal barrier. Compared to… Show more

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“…Especially for the production of recombinant IgA antibodies, technical issues were limiting. For example, the purification of IgA requires new capture materials, as the usually for IgG purification used materials do not bind IgA ( 112 , 223 ). Another issue is the natural ability of IgA to form different multimeric forms, as these require high demands in regard of manufacturability and characterization (e.g.…”
Section: Iga As Therapeutic Antibodymentioning
confidence: 99%
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“…Especially for the production of recombinant IgA antibodies, technical issues were limiting. For example, the purification of IgA requires new capture materials, as the usually for IgG purification used materials do not bind IgA ( 112 , 223 ). Another issue is the natural ability of IgA to form different multimeric forms, as these require high demands in regard of manufacturability and characterization (e.g.…”
Section: Iga As Therapeutic Antibodymentioning
confidence: 99%
“…One of the biggest issues are the number of glycosylation sites, because the IgA hinge region is heavily glycosylated, it is problematic to generate consistent glycoforms, as well as to implement proper quality control ( 101 , 112 , 120 , 224 ). Furthermore, the complexity of IgA in regard to protein size and glycosylation leads to lower expression yields compared to recombinant IgG ( 101 , 223 ).…”
Section: Iga As Therapeutic Antibodymentioning
confidence: 99%
See 1 more Smart Citation