Perspective: COVID-19 and Its Neurologic Sequelae

Abstract

COVID-19 led to a catastrophic, international, public health crisis after its first detection in 2019 [1]. Though it is primarily a respiratory virus, it impacts the central and peripheral nervous systems leading to further COVID-19-associated disability [2]. This Perspective reviews our current understanding of the neurological sequelae of COVID-19 and the gaps in our understanding of their treatment and epidemiology.

Impact of the COVID‐19 pandemic on acute stroke care: An analysis of the 24‐month data from a comprehensive stroke center in Shanghai, China

“…In this retrospective cohort study, our findings suggest the possible delays of stroke care in patients with ED visits and hospitaliza- Growing evidence indicates a nonnegligible prevalence of neurological involvement during COVID-19 infection or postinfection period, including seizures, encephalopathy, acute ischemic stroke, etc. [14][15][16][17] The systematic review of 100,949 patients with COVID-19 from the early phase of the pandemic to the omicron waves reported a pooled incidence of acute ischemic stroke in patients hospitalized for COVID-19 of 0.9%. 18 stroke.…”

“…Growing evidence indicates a nonnegligible prevalence of neurological involvement during COVID‐19 infection or postinfection period, including seizures, encephalopathy, acute ischemic stroke, etc. 14 , 15 , 16 , 17 The systematic review of 100,949 patients with COVID‐19 from the early phase of the pandemic to the omicron waves reported a pooled incidence of acute ischemic stroke in patients hospitalized for COVID‐19 of 0.9%. 18 Though the frequency seems low, concomitant COVID‐19 infection and stroke might result in poor outcomes despite aggressive medical treatment, suggesting an urgency for timely diagnosis and emergency treatment of COVID‐19‐associated stroke.…”