Perspective: improving vitamin D status in the management of COVID-19

Ebadi, Maryam; Montaño-Loza, Aldo J.

doi:10.1038/s41430-020-0661-0

Cited by 175 publications

(192 citation statements)

References 32 publications

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“…Although some trials are in progress, thus far, no study has investigated the effect of vitamin D on the course and outcome of COVID-19, Hence, a practical guideline advising the use of vitamin D supplements in the general population or in critically ill patients with COVID-19 has not been introduced yet. Based on a previous study that was conducted on patients with respiratory disease, Ebadi et al suggested a treatment plan for vitamin D supplementation, which could quickly and safely increase serum 25(OH)D levels [ 21 ]. They suggested that patients with low circulating levels of vitamin D (below 50 nmol/L) should be offered 50,000 IU of vitamin D supplementation twice weekly at diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a retrospective study

et al. 2020

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Purpose Vitamin D deficiency has been reported as a key factor in the development of infectious diseases such as respiratory tract infections and inflammatory processes like acute respiratory distress syndrome. However, the impact of vitamin D on the severity and outcome of COVID-19 is still not fully known. Herein, we aimed to evaluate the prognostic role of serum vitamin D concentration on the extent of lung involvement and final outcome in patients with COVID-19. Methods Seventy-three subjects with confirmed diagnosis of COVID-19 were investigated in this study. The patients had been admitted to our academic hospital from February 28, 2020 to April 19, 2020. Demographic and clinical data, serum 25(OH)D levels, and findings of initial chest computed tomography were recorded. Linear and binary logistic regression, cox regression and ROC curve tests were used for statistical analysis. Results The mean age of patients was 55.18 ± 14.98 years old; 46.4% were male. Mean serum 25(OH)D concentration was significantly lower in the deceased (13.83 ± 12.53 ng/ mL compared with discharged patients (38.41 ± 18.51 ng/mL) ( P < 0.001). Higher levels of 25(OH)D were associated with significantly less extent of total lung involvement ( β = − 0.10, P = 0.004). In addition, vitamin D deficiency [25(OH) D < 25 ng/mL] was associated with a significant increase in the risk of mortality (hazard ratio = 4.15, P = 0.04). Conclusion This study suggests that serum vitamin D status might provide useful information regarding the clinical course, extent of lung involvement and outcome of patients with COVID-19. However, further studies with larger sample size are needed to confirm these findings.

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Section: Discussionmentioning

confidence: 99%

Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a retrospective study

et al. 2020

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“…However, the vitamin D levels correlation with deaths per million population among the studied countries seemed insigni cant. As vitamin D is already known to boost the immune system and play an important role in reducing respiratory disease severity [4][5][6], it would be safe to assume its positive interaction with COVID-19 [3]. The biological role of vitamin D levels in avoiding infection and favorable outcomes of the COVID-19 must be thoroughly investigated through available medical records or survey-based epidemiological study with the follow-up scrutiny through controlled clinical trials for the protective effect.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a peer-review publication had negatively correlated the serum Vitamin D level in European countries with reported COVID-19 infection cases and deaths per million populations [2]. Vitamin D is known to exert a positive effect on the immunity and general health of individuals [3]. It had been indicated to protect from other acute respiratory tract infections and the adverse outcomes [4,5].…”

Section: Introductionmentioning

confidence: 99%

Revisiting the role of vitamin D levels in the prevention of COVID-19 infection and mortality in European countries post infections peak

Singh

Kaur

Singh

2020

Preprint

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Various studies are underway to identify protective variables for the COVID-19 pandemic. We hypothesized that if indeed the Vitamin D levels would be protective in the European population, as recently proposed, the correlation would become more robust when the countries had passed the infection peak as on May 12, 2020, compared to April 8, 2020, when the majority had not. Comparative analysis of data from the mentioned stages indicated a significant increase in negative correlation of vitamin D levels with COVID-19 cases per million population in later stage (r(20): -0.5504; R2=0.3029; p-value: 0.0119 vs r(20): -0.4435; R2=0.1967; p-value: 0.0501) whereas the correlation with deaths per million population became insignificant (r(20): -0.3935; R2=0.1549; p-value: 0.0860 vs r(20): -0.4378; R2=0.1917; p-value: 0.0535). Considering divergence of vitamin D levels from the mean in subgroups, e.g. children, women, aged, dedicated exploratory studies with carefully chosen matched target groups is advisable.

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“…Recent research reports have highlighted the role of vitamin D as a potent immunomodulator to combat influenza and COVID-19. It has been suggested that supplementation of vitamin D at an oral dose of 200,000 to 300,000 international units (IU) and other micronutrients for a week can strengthen the immune system against COVID-19 [ 96 , 97 ]. An observational study also demonstrated an inverse relationship between the critical outcome of COVID-19 and serum levels of 25 hydroxyvitamin D (25(OH)D) [ 98 ].…”

Section: Vitamins and Immune Systemmentioning

confidence: 99%

Effective Immune Functions of Micronutrients against SARS-CoV-2

et al. 2020

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The third coronavirus outbreak in the last two decades has caused significant damage to the world’s economy and community health. The highly contagious COVID-19 infection has affected millions of people to date and has led to hundreds of thousands of deaths worldwide. Aside from the highly infectious nature of SARS-CoV-2, the lack of a treatment or vaccine has been the main reason for its spread. Thus, it has become necessary to find alternative methods for controlling SARS-CoV-2. For the present review, we conducted an online search for different available nutrition-based therapies for previously known coronavirus infections and RNA-based virus infections as well as general antiviral therapies. These treatments have promise for combating COVID-19, as various nutrients and minerals play direct and indirect roles in the control and prevention of this newly emerged viral infection. The patients’ nutritional status with COVID-19 must be analyzed before administering any treatment, and nutritional supplements should be given to the affected individuals along with routine treatment. We suggest a potential interventional role of nutrients to strengthen the immune system against the emerging infection caused by COVID-19.

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Perspective: improving vitamin D status in the management of COVID-19

Cited by 175 publications

References 32 publications

Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a retrospective study

Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a retrospective study

Revisiting the role of vitamin D levels in the prevention of COVID-19 infection and mortality in European countries post infections peak

Effective Immune Functions of Micronutrients against SARS-CoV-2

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