2023
DOI: 10.1016/j.ejphar.2023.175668
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Perspective insights of small molecules, phytoconstituents and biologics in the management of psoriasis: A focus on targeting major inflammatory cytokine pathways

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Cited by 9 publications
(2 citation statements)
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“…It is similar to the PI3K-AKT pathway above in that it is activated by cytokines such as IL-17 and IL-23 and serves as a link between immune-mediated inflammatory pathology and the overproduction of epidermal keratinocytes. Therefore, the JAK/STAT pathway can be considered as one of the other major targets for the treatment of psoriasis with natural products [ 252 ].…”
Section: Discussionmentioning
confidence: 99%
“…It is similar to the PI3K-AKT pathway above in that it is activated by cytokines such as IL-17 and IL-23 and serves as a link between immune-mediated inflammatory pathology and the overproduction of epidermal keratinocytes. Therefore, the JAK/STAT pathway can be considered as one of the other major targets for the treatment of psoriasis with natural products [ 252 ].…”
Section: Discussionmentioning
confidence: 99%
“…The analysis of the degree of severity of skin disorders is majorly based on a few standards, including skin complexation, ethnicity, gender, age, genetics, clinical, geographical and environmental factors, hygiene, and socioeconomic status of a person . The skin disorders comprise a broad range of diseases such as atopic dermatitis, psoriasis, , melanoma, , vitiligo, and acne vulgaris . The success of currently available topical treatment modalities is hindered due to the presence of stratum corneum (SC), which acts as a solid barrier that restricts the effective penetration of therapeutics.…”
Section: Introductionmentioning
confidence: 99%