Perspective on Management of Low-Dose Computed Tomography Findings on Low-Dose Computed Tomography Examinations for Lung Cancer Screening. From the International Association for the Study of Lung Cancer Early Detection and Screening Committee

Henschke, Claudia; Huber, Rudolf; Jiang, Long; Yang, Dawei; Cavic, Milena; Schmidt, Heidi; Kazerooni, Ella; Zulueta, Javier J.; Sales dos Santos, Ricardo; Ventura, Luigi; Yang, Dawei; Zulueta, Javier J.; Viola, Lucia; Mohan, Anant; Lee, Choon-Taek; Cavic, Milena; Schmidt, Heidi; Kazerooni, Ella; dos Santos, Ricardo Sales; Kerpel-Fronius, Anna; Henschke, Claudia; Ventura, Luigi; Jiang, Long; Sozzi, Gabriella; Tammemägi, Martin; Lam, Stephen; Huber, Rudolf

doi:10.1016/j.jtho.2023.11.013

Cited by 5 publications

(3 citation statements)

References 102 publications

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“…Important characteristics of lung cancer, compared with other types of cancer, include a rapid onset period, a higher malignancy, and a more difficult diagnosis of the disease in its early stages ( 14 ). Due to developments in and the increasing utility of computer tomography (CT) in most countries, the detection of pulmonary nodules is now the most important early indicator of lung cancer ( 15 , 16 ). It is well documented that smoking and genetic risk factors are risk factors of lung cancer ( 17 , 18 ).…”

Section: Introductionmentioning

confidence: 99%

Association between non-alcoholic fatty liver disease and the risk of pulmonary nodules in patients with intestinal polyps

Wu,

Zhang,

Chen

et al. 2024

J Thorac Dis

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Section: Introductionmentioning

confidence: 99%

Association between non-alcoholic fatty liver disease and the risk of pulmonary nodules in patients with intestinal polyps

Wu,

Zhang,

Chen

et al. 2024

J Thorac Dis

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“…1 Therefore, early screening and diagnosis of lung cancer have been deemed essential. 2 Screening for NSCLC primarily relies on low-dose computed tomography scans; however, frequent screenings can lead to cumulative radiation exposure. 3 Tissue biopsy serves as the gold standard for diagnosing NSCLC, yet the tissue heterogeneity of NSCLC determines that even with comprehensive biopsies, only a limited portion of the NSCLC tumor is represented, 4 tissue biopsy collection also poses certain limitations and risks.…”

Section: Introductionmentioning

confidence: 99%

“…The primary reason for the high mortality rate of nonsmall cell lung cancer (NSCLC) has been the fact that patients have typically progressed to advanced stages by the time of diagnosis . Therefore, early screening and diagnosis of lung cancer have been deemed essential . Screening for NSCLC primarily relies on low-dose computed tomography scans; however, frequent screenings can lead to cumulative radiation exposure .…”

Section: Introductionmentioning

confidence: 99%

Dual-Modal Aptasensor for Sensitive Detection of Non-Small Cell Lung Cancer Exosomes Utilizing Two-Dimensional Nanopaper Co@g-C₃N₄@PB

Xu,

Zhang,

et al. 2024

ACS Omega

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Nonsmall cell lung cancer (NSCLC), due to its lack of early symptoms, has become one of the leading causes of cancerrelated deaths globally. Exosomes, small membrane vesicles secreted by cells, are widely present in human bodily fluids. In the bodily fluids of NSCLC patients, the quantity of extracellular vesicles is double that of healthy individuals, suggesting their potential as biomarkers for screening NSCLC. This study designed a dual-modal aptasensor that integrated excellent sensitivity in electrochemical detection and portability in fluorescence detection into one device. AuNPs were functionalized with exosomecapturing probes containing thiol-modified CD63 aptamers, which were immobilized on screen-printed gold electrodes. On the other hand, the carboxylated CD63 aptamer was immobilized on the surface of PB-modified g-C 3 N 4 loaded with Co-SANs particles

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Diagnostic performance of rapid on‐site evaluation during bronchoscopy for lung cancer: A comprehensive meta‐analysis

Chen,

Lu,

Chang

et al. 2024

Cancer Cytopathology

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BackgroundLung cancer is the leading cause of cancer‐related mortality worldwide. Screening high‐risk populations for lung cancer with low‐dose computed tomography (LDCT) reduces lung cancer mortality. Bronchoscopy is a diagnostic procedure used to monitor patients suspected of having lung cancer after LDCT. Rapid on‐site evaluation (ROSE) can improve the diagnostic accuracy of endobronchial ultrasound–guided transbronchial needle aspiration (EBUS‐TBNA), although its diagnostic value remains unclear. In this meta‐analysis, the authors evaluated the diagnostic accuracy of ROSE during bronchoscopy.MethodsThe PubMed, Embase, and Cochrane Library databases were searched for studies evaluating the diagnostic accuracy of ROSE for lung cancer during bronchoscopy. Studies evaluating the performance of ROSE and articles providing sufficient data for constructing a 2 × 2 table on a per‐lesion basis were included. A meta‐analysis was conducted using a bivariate random‐effects model.ResultsIn total, 32 studies involving 8243 lung lesions were included with a pooled sensitivity of 91.8% and a pooled specificity of 94.9%. Subgroup analysis of 12 studies involving 2929 specimens from patients who underwent computed tomography revealed a pooled sensitivity of 93.8% and a pooled specificity of 96%. Further subgroup analysis of seven studies on the diagnostic outcomes of ROSE for intrathoracic or mediastinal lymph nodes through EBUS‐TBNA for lung cancer staging revealed a pooled sensitivity of 90.1% and a pooled specificity of 96.9%.ConclusionsROSE exhibited high sensitivity and specificity for diagnosing lung cancer during bronchoscopy. It also exhibited high sensitivity in detecting lung cancer in patients undergoing LDCT and higher specificity for nodal staging with EBUS‐TBNA.

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Perspective on Management of Low-Dose Computed Tomography Findings on Low-Dose Computed Tomography Examinations for Lung Cancer Screening. From the International Association for the Study of Lung Cancer Early Detection and Screening Committee

Cited by 5 publications

References 102 publications

Association between non-alcoholic fatty liver disease and the risk of pulmonary nodules in patients with intestinal polyps

Association between non-alcoholic fatty liver disease and the risk of pulmonary nodules in patients with intestinal polyps

Dual-Modal Aptasensor for Sensitive Detection of Non-Small Cell Lung Cancer Exosomes Utilizing Two-Dimensional Nanopaper Co@g-C₃N₄@PB

Diagnostic performance of rapid on‐site evaluation during bronchoscopy for lung cancer: A comprehensive meta‐analysis

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Perspective on Management of Low-Dose Computed Tomography Findings on Low-Dose Computed Tomography Examinations for Lung Cancer Screening. From the International Association for the Study of Lung Cancer Early Detection and Screening Committee

Cited by 5 publications

References 102 publications

Association between non-alcoholic fatty liver disease and the risk of pulmonary nodules in patients with intestinal polyps

Association between non-alcoholic fatty liver disease and the risk of pulmonary nodules in patients with intestinal polyps

Dual-Modal Aptasensor for Sensitive Detection of Non-Small Cell Lung Cancer Exosomes Utilizing Two-Dimensional Nanopaper Co@g-C3N4@PB

Diagnostic performance of rapid on‐site evaluation during bronchoscopy for lung cancer: A comprehensive meta‐analysis

Contact Info

Product

Resources

About

Dual-Modal Aptasensor for Sensitive Detection of Non-Small Cell Lung Cancer Exosomes Utilizing Two-Dimensional Nanopaper Co@g-C₃N₄@PB