Perspectives and Challenges on the Potential Use of Exosomes in Bioartificial Pancreas Engineering

Canning, Priyadarshini; Alwan, Abdelrahman; Khalil, Fatma; Zhang, Yuanyuan; Opara, Emmanuel C.

doi:10.1007/s10439-022-03004-0

Cited by 9 publications

(4 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EXOs are enriched in numerous angiogenesis-related proteins, lipids and RNAs, including messenger RNA (mRNA) and miRNAs that could start diverse signaling pathways in endothelial cells inducing the expression of numerous trophic factors [70]. EXOs' interaction with target cells involves ligands on the exosomal membrane surface binding to receptors on the target cell.…”

Section: Exosomes and Its Potential In Mscs Vascularizationmentioning

confidence: 99%

Mesenchymal Stem Cell in Pancreatic Islet Transplantation

Barachini,

Biso,

Kolachalam

et al. 2023

Biomedicines

View full text Add to dashboard Cite

Pancreatic islet transplantation is a therapeutic option for achieving physiologic regulation of plasma glucose in Type 1 diabetic patients. At the same time, mesenchymal stem cells (MSCs) have demonstrated their potential in controlling graft rejection, the most fearsome complication in organ/tissue transplantation. MSCs can interact with innate and adaptive immune system cells either through direct cell-cell contact or through their secretome including exosomes. In this review, we discuss current findings regarding the graft microenvironment of pancreatic islet recipient patients and the crucial role of MSCs operation as cell managers able to control the immune system to prevent rejection and promote endogenous repair. We also discuss how challenging stressors, such as oxidative stress and impaired vasculogenesis, may jeopardize graft outcomes. In order to face these adverse conditions, we consider either hypoxia-exposure preconditioning of MSCs or human stem cells with angiogenic potential in organoids to overcome islets’ lack of vasculature. Along with the shepherding of carbon nanotubes-loaded MSCs to the transplantation site by a magnetic field, these studies look forward to exploiting MSCs stemness and their immunomodulatory properties in pancreatic islet transplantation.

show abstract

Section: Exosomes and Its Potential In Mscs Vascularizationmentioning

confidence: 99%

Mesenchymal Stem Cell in Pancreatic Islet Transplantation

Barachini,

Biso,

Kolachalam

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

“…One such possibility is the exosome-conditioning of bioartificial products. The construction of encapsulated pancreatic islet grafts as an insulin delivery platform is explored for the management of Type 1 diabetes patients, and exosomes may play a valuable role in the improvement of these bioartificial constructs 22 . While naïve exosomes rely on their intrinsic properties determined mostly by the source cells, specific features can also be selectively accommodated by pre-and post-release engineering procedures.…”

Section: Exosome Therapy and Exoengineeringmentioning

confidence: 99%

Olesya Gusachenko

Gusachenko¹

2023

SciRevs.Biology

View full text Add to dashboard Cite

Exosomes or, more broadly, small extracellular vesicles are produced by all cells. They contain an array of biologically active molecules by which exosomes can influence the extracellular environment and affect the properties of other cells. Recognition of their biological role has come a long way from the mere function in the disposal of cellular waste to a concept of universal intercellular vehicle mediating near and long-distance communication in normal and pathological states. As a result, in recent years exosomes have gained much interest in their potential exploitation for therapeutic use. This short review is aimed at presenting a brief exploration of the history of exosome recognition coupled with a snapshot of newly developing exosome-based technologies, touching upon some recent achievements and examples of application.

show abstract

“…Additional review articles highlighted emerging research topics in biomedical engineering. These notable topics included the use of exosomes in bioartificial pancreas engineering [3], engineering strategies for osteochondral regeneration [9], computational approaches for improved EEG signal processing [5], and the use of machine and deep learning methods for automatic detection of retinal diseases [11]. In summary, these reviews reiterated the importance of standardized protocols and continued innovation, which will help guide future research efforts for the next 50 years of ABME and beyond.…”

Section: Special Issue: 50th Anniversary Of Abmementioning

confidence: 99%

Annals of Biomedical Engineering 2022 Year in Review

Norris

2023

Ann Biomed Eng

View full text Add to dashboard Cite

Perspectives and Challenges on the Potential Use of Exosomes in Bioartificial Pancreas Engineering

Cited by 9 publications

References 48 publications

Mesenchymal Stem Cell in Pancreatic Islet Transplantation

Mesenchymal Stem Cell in Pancreatic Islet Transplantation

Olesya Gusachenko

Annals of Biomedical Engineering 2022 Year in Review

Contact Info

Product

Resources

About