2021
DOI: 10.1107/s1600577521000400
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Perspectives for microbeam irradiation at the SYRMEP beamline

Abstract: It has been shown previously both in vitro and in vivo that microbeam irradiation (MBI) can control malignant tumour cells more effectively than the clinically established concepts of broad beam irradiation. With the aim to extend the international capacity for microbeam research, the first MBI experiment at the biomedical beamline SYRMEP of the Italian synchrotron facility ELETTRA has been conducted. Using a multislit collimator produced by the company TECOMET, arrays of quasi-parallel microbeams were success… Show more

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Cited by 4 publications
(4 citation statements)
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“…The dose rates used here (<0.2 Gy/s) fall well below the range of dose rates previously attributed to FLASH effects [39]. Previous work employed synchrotron sources [21,26,40,41], and therefore, it has been impossible to distinguish if any differential effects of MRT and BB irradiation were due to the spatial fractionation or a result of FLASH effects. Here, we can discount any involvement of FLASH effects and attribute the differential response of normal and tumour cells wholly to the irradiation with high (peak) and low (valley) doses, either in the form of MRT or by post-mixing of separate BB irradiations.…”
Section: Discussionmentioning
confidence: 85%
“…The dose rates used here (<0.2 Gy/s) fall well below the range of dose rates previously attributed to FLASH effects [39]. Previous work employed synchrotron sources [21,26,40,41], and therefore, it has been impossible to distinguish if any differential effects of MRT and BB irradiation were due to the spatial fractionation or a result of FLASH effects. Here, we can discount any involvement of FLASH effects and attribute the differential response of normal and tumour cells wholly to the irradiation with high (peak) and low (valley) doses, either in the form of MRT or by post-mixing of separate BB irradiations.…”
Section: Discussionmentioning
confidence: 85%
“…The importance to study the effects of high dose rate radiotherapy in veterinary patients before proposing human clinical trials has been recognized because dogs, for instance, suffer from spontaneous tumors which are very similar in size, histology, and natural course of the disease, compared to human patients [ 45 , 46 ]. The first successful veterinary studies were and are conducted with FLASH radiotherapy [ 21 , 22 ] and with MRT, the latter focused on the treatment of dogs with malignant brain tumors [ 28 ].…”
Section: Discussionmentioning
confidence: 99%
“…Internationally, there are currently two biomedical beamlines dedicated to the development of microbeam radiotherapy: ID17 at the Europeans Synchrotron Radiation Facility (ESRF) in France and the Imaging and Biomedical Beamline (IMBL) at the Australian Synchrotron in Melbourne [ 22 , 23 , 24 ]. Microbeam studies have also been conducted at Spring 8 [ 25 , 26 , 27 ] and the feasibility to conduct MRT at the biomedical beamline SYRMEP at the Elettra Sincrotrone Trieste in Italy has been demonstrated [ 28 ].…”
Section: Introductionmentioning
confidence: 99%
“…Over the last decade, high-dose-rate irradiation has increasingly come into focus for superior preservation of normal tissue [19]. Microbeam irradiation (MBI) is an experimental irradiation technique characterized by a high dose rate and spatial dose fractionation of synchrotron-generated X-ray beams in the micrometer range [19]. A multislit collimator (MSC) is inserted into the X-ray beam, producing an array of quasi-parallel microbeams.…”
Section: Introductionmentioning
confidence: 99%