Perspectives in Pharmacological Research on Drug Dependence

Genital Warts Do Not Respond to Systemic Recombinant Interferon Alfa-2a Treatment during Cannabis Consumption

“…The plasma level of A'-THC in man after smoking is 10 mg, rapidly drops to 10-20 ng/ml after 30 min and reaches about 1 ng/ml at 4 h. A'-THC is metabo lized in the liver, and A'-THC metabolites arc excreted mainly in the faeces. Minor amounts of metabolites appear in the urine [ 18]. The half-life of THC is approxi mately 1 week, and it takes 1 month for complete elimina tion (80% by the intestinal route.…”

“…The smoke of a marihuana cigarette contains twice as many carcinogens (benzanthracene and benzopyrene) as a tobacco cigarette of the same weight [17]. Marihuana smoke enhances abnormalities of DNA metabolism and has an adverse effect on the male germ cells [ 18]. Extracts and smoke condensates of cannabis are mutagenic in the in vitro Ames test, whereas pure cannabinoids are not [17].…”