Perspectives: MRI of angiogenesis

Neeman, Michal

doi:10.1016/j.jmr.2018.04.008

Cited by 7 publications

(3 citation statements)

References 119 publications

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“…4 ). Angiogenesis is an important component in the remodeling of tissues, and its analysis is a standardized method for assessing vascular physiological characteristics [ 14 , 15 ]. The percentage of the enhanced area in the scar was visually evaluated based on the subjective opinion of the evaluators.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of incision healing status after transverse uterine fundal incision for cesarean delivery and postoperative pregnancy: a ten-year single-center retrospective study

Kotsuji,

Shibata,

Nakago

et al. 2024

BMC Pregnancy Childbirth

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Background Transverse uterine fundal incision (TUFI) is a beneficial procedure for mothers and babies at risk due to placenta previa-accreta, and has been implemented worldwide. However, the risk of uterine rupture during a subsequent pregnancy remains unclear. We therefore evaluated the TUFI wound scar to determine the approval criteria for pregnancy after this surgery. Methods Between April 2012 and August 2022, we performed TUFI on 150 women. Among 132 of the 150 women whose uteruses were preserved after TUFI, 84 women wished to conceive again. The wound healing status, scar thickness, and resumption of blood flow were evaluated in these women by magnetic resonance imaging (MRI) and sonohysterogram at 12 months postoperatively. Furthermore, TUFI scars were directly observed during the Cesarean sections in women who subsequently conceived. Results Twelve women were lost to follow-up and one conceived before the evaluation, therefore 71 cases were analyzed. MRI scans revealed that the “scar thickness”, the thinnest part of the scar compared with the normal surrounding area, was ≥ 50% in all cases. The TUFI scars were enhanced in dynamic contrast-enhanced MRI except for four women. However, the scar thickness in these four patients was greater than 80%. Twenty-three of the 71 women conceived after TUFI and delivered live babies without notable problems until August 2022. Their MRI scans before pregnancy revealed scar thicknesses of 50–69% in two cases and ≥ 70% in the remaining 21 cases. And resumption of blood flow was confirmed in all patients except two cases whose scar thickness ≥ 90%. No evidence of scar healing failure was detected at subsequent Cesarean sections, but partial thinning was found in two patients whose scar thicknesses were 50–69%. In one woman who conceived seven months after TUFI and before the evaluation, uterine rupture occurred at 26 weeks of gestation. Conclusions Certain criteria, including an appropriate suture method, delayed conception for at least 12 months, evaluation of the TUFI scar at 12 months postoperatively, and cautious postoperative management, must all be met in order to approve a post-TUFI pregnancy. Possible scar condition criteria for permitting a subsequent pregnancy could include the scar thickness being ≥ 70% of the surrounding area on MRI scans, at least partially resumed blood flow, and no abnormalities on the sonohysterogram. Trial registration Retrospectively registered.

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Section: Methodsmentioning

confidence: 99%

Evaluation of incision healing status after transverse uterine fundal incision for cesarean delivery and postoperative pregnancy: a ten-year single-center retrospective study

Kotsuji,

Shibata,

Nakago

et al. 2024

BMC Pregnancy Childbirth

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“…Doppler techniques can be added to a normal B-mode US to provide information on vascularity [5] , but are limited in breast cancer due to technical factors such as low flow rate [6] . Various MRI methods are available that detect and quantify angiogenesis [7] , for example, blood oxygen level dependent and susceptibility weighted MRI, although these are specialist sequences that are not widely available. Although tumour vasculature can be highlighted using dynamic contrast enhanced methods, quantification of these data adds complexity to the clinical procedure and data interpretation, hence is not undertaken routinely in the breast [8] , [9] .…”

Section: Introductionmentioning

confidence: 99%

An optoacoustic imaging feature set to characterise blood vessels surrounding benign and malignant breast lesions

et al. 2022

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“…To date, clinical available imaging techniques to study plaque angiogenesis and subsequent intraplaque hemorrhage, such as PET [12], CT [13], and MRI [14], do not have sufficient spatial resolution to visualize cellular events or image the detailed microvessels network in small size animal models. Two-photon intravital microscopy (2P-IVM), due to its high resolution, can overcome these limitations, allowing detailed 3D reconstructions of plaque angiogenesis and real-time evaluation of target dynamic processes, such as in vivo hemorrhage [7,15,16].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Microvessel Permeability in Murine Atherosclerotic Vein Grafts Using Two-Photon Intravital Microscopy

Baganha

Ritsma

Quax

et al. 2020

IJMS

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Plaque angiogenesis and plaque hemorrhage are major players in the destabilization and rupture of atherosclerotic lesions. As these are dynamic processes, imaging of plaque angiogenesis, especially the integrity or leakiness of angiogenic vessels, can be an extremely useful tool in the studies on atherosclerosis pathophysiology. Visualizing plaque microvessels in 3D would enable us to study the architecture and permeability of adventitial and intimal plaque microvessels in advanced atherosclerotic lesions. We hypothesized that a comparison of the vascular permeability between healthy continuous and fenestrated as well as diseased leaky microvessels, would allow us to evaluate plaque microvessel leakiness. We developed and validated a two photon intravital microscopy (2P-IVM) method to assess the leakiness of plaque microvessels in murine atherosclerosis-prone ApoE3*Leiden vein grafts based on the quantification of fluorescent-dextrans extravasation in real-time. We describe a novel 2P-IVM set up to study vessels in the neck region of living mice. We show that microvessels in vein graft lesions are in their pathological state more permeable in comparison with healthy continuous and fenestrated microvessels. This 2P-IVM method is a promising approach to assess plaque angiogenesis and leakiness. Moreover, this method is an important advancement to validate therapeutic angiogenic interventions in preclinical atherosclerosis models.

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Perspectives: MRI of angiogenesis

Cited by 7 publications

References 119 publications

Evaluation of incision healing status after transverse uterine fundal incision for cesarean delivery and postoperative pregnancy: a ten-year single-center retrospective study

Evaluation of incision healing status after transverse uterine fundal incision for cesarean delivery and postoperative pregnancy: a ten-year single-center retrospective study

An optoacoustic imaging feature set to characterise blood vessels surrounding benign and malignant breast lesions

Assessment of Microvessel Permeability in Murine Atherosclerotic Vein Grafts Using Two-Photon Intravital Microscopy

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