Perspectives of Biological Analysis in Latin America Using Multi and Comprehensive Two-Dimensional Gas Chromatography: A Mini-review

Fernandez, Miriany Avelino Moreira; André, Leiliane Coelho; Cardeal, Zenilda de Lourdes

doi:10.1007/s10337-020-03910-2

Cited by 2 publications

(1 citation statement)

References 46 publications

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“…pg/l or kg, ng/l or kg) of chemicals that could cause sub‐lethal changes to animal behaviour (Jiang & Li, 2020). However, equipment and analysis costs are still a limiting factor in the widespread application of these approaches (see Fernandez, André & Cardeal, 2020). Thankfully, data on complex exposure scenarios in the wild are also increasingly accessible due to the availability of large‐scale, open‐access databases documenting the occurrence of environmental contaminants, for example the EPA NCOD Database (EPA, 2021b), the NORMAN EMPODAT Database (NORMAN, 2022), the UBA Pharmaceuticals in the Environment Database (UBA, 2021), and the Global Monitoring of Pharmaceuticals Project (Wilkinson et al .…”

Section: Increasing Environmental Realismmentioning

confidence: 99%

Frontiers in quantifying wildlife behavioural responses to chemical pollution

et al. 2022

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Animal behaviour is remarkably sensitive to disruption by chemical pollution, with widespread implications for ecological and evolutionary processes in contaminated wildlife populations. However, conventional approaches applied to study the impacts of chemical pollutants on wildlife behaviour seldom address the complexity of natural environments in which contamination occurs. The aim of this review is to guide the rapidly developing field of behavioural ecotoxicology towards increased environmental realism, ecological complexity, and mechanistic understanding. We identify research areas in ecology that to date have been largely overlooked within behavioural ecotoxicology but which promise to yield valuable insights, including within-and among-individual variation, social networks and collective behaviour, and multi-stressor interactions. Further, we feature methodological and technological innovations that enable the collection of data on pollutant-induced behavioural changes at an unprecedented resolution and scale in the laboratory and the field. In an era of rapid environmental change, there is an urgent need to advance our understanding of the real-world impacts of chemical pollution on wildlife behaviour. This review therefore provides a roadmap of the major outstanding questions in behavioural ecotoxicology and highlights the need for increased cross-talk with other disciplines in order to find the answers.

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Section: Increasing Environmental Realismmentioning

confidence: 99%

Frontiers in quantifying wildlife behavioural responses to chemical pollution

et al. 2022

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Environmental impacts of drugs against parasitic vector-borne diseases and the need to integrate sustainability into their development and use

Lima,

Uliassi,

Thoré

et al. 2024

Open Res Europe

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Background The current scientific discourse on environmental impacts of veterinary medicines mostly focuses on ectoparasiticides. Meanwhile, the environmental impacts of widely prescribed drugs for the treatment of human and animal parasitic vector-borne diseases (PVBD) remain largely unexplored. There is thus a need for evidence-based information to support guidelines and protocols for sustainable One Health PVBD drug development and use, while promoting greener research practices. Here, we reflect on the potential environmental impacts of PVBD drugs in current use, and the environmental impact of our research practices for developing new antiparasitics. Methods We conducted a survey of the membership of the “One Health drugs against parasitic vector borne diseases in Europe and beyond” Cooperation in Science and Technology (COST) Action 21111 (OneHealth drugs) to assess the current appreciation of sustainable drug design concepts and the extent to which One Health and sustainability principles are integrated into PVBD drug discovery and development. The survey also explored which human, technical, and funding resources are currently used in Europe and neighbouring countries in PVBD drugs research. Results The survey was conducted and analysed by OneHealth drugs and garnered 89 respondents, representing a response rate of 66% from 32 countries, predominantly European. 87% of participating collaborators worked in Academia; research groups were small (60% with 1–4 researchers) and mostly consist of few researchers, mostly at early career stages (63% <35 years old). Collaborations were mostly between academics, and 60% collaborated with non-European researchers, while funding was mostly from national governments. Motivation for greener research practices was high but there was as yet low implementation of green strategies or the incorporation of ecotoxicological test in drug development workflows, due to cost and unfamiliarity. Conclusions We highlight the need for early-ecotoxicological testing of new drug candidates and suggest best practices as we move towards standardized protocols in developing safe and efficacious PVBD drugs.

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Perspectives of Biological Analysis in Latin America Using Multi and Comprehensive Two-Dimensional Gas Chromatography: A Mini-review

Cited by 2 publications

References 46 publications

Frontiers in quantifying wildlife behavioural responses to chemical pollution

Frontiers in quantifying wildlife behavioural responses to chemical pollution

Environmental impacts of drugs against parasitic vector-borne diseases and the need to integrate sustainability into their development and use

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