Perspectives of drug-based neuroprotection targeting mitochondria

Procaccio, Vincent; Bris, Céline; Barca, Juan Manuel Chao de la; Oca, Florine; Chevrollier, Arnaud; Amati‐Bonneau, Patrizia; Bonneau, Dominique; Reynier, Pascal

doi:10.1016/j.neurol.2014.03.005

Cited by 72 publications

(54 citation statements)

References 61 publications

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“…These include the sirtuins and 5′ AMP-activated protein kinase pathway, 156 estrogen related receptor (ERR)-α, 157 estrogen related receptor (ERR)-γ, 158 and nuclear respiratory factor 1. 159 Although the use of the 5′ AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide ribonucleotide for doping in cycling and other professional sports is suspect, clinical trial results assessing its effect on performance have been generally disappointing.…”

Section: Skeletal Muscle Metabolic Abnormalitiesmentioning

confidence: 99%

Pathogenesis of the Limb Manifestations and Exercise Limitations in Peripheral Artery Disease

Hiatt¹,

Armstrong²,

Larson³

et al. 2015

Circulation Research

137

118

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P eripheral artery disease (PAD) is initiated by atherogenic mechanisms common to all major vascular territories but encompasses several distinctly important clinical sequelae.1 The global burden of PAD is large and rising, with substantial morbidity and mortality found in high-, middle-, and low-income countries. 2 The atherosclerotic occlusive disease underlying PAD is associated with an exercise limitation in the majority of patients, whereas the classic symptoms of intermittent claudication, ischemic rest pain, and ischemic ulceration are less common manifestations. 3 Patients with PAD are also at increased risk of myocardial infarction, ischemic stroke, heart failure, renovascular hypertension, and vascular death reflecting the systemic atherosclerotic burden. [4][5][6] The epidemiology of Peripheral Artery Disease Compendium© 2015 American Heart Association, Inc. The diagnosis of PAD can be ascertained by simple hemodynamic measurements, in particular, the ankle-brachial index (ABI), a test performed by measuring the systolic blood pressure in each arm and the dorsalis pedis and posterior tibial arteries of each ankle. The highest of the dorsalis pedis or posterior tibial artery pressures is the numerator of the ABI specific to each leg, whereas the highest arm pressure on either side is the denominator. A ratio of <0.90 in either leg is considered hemodynamic evidence of PAD. 16 When imaged, PAD can be characterized as one or more arterial stenoses or occlusions involving the distal aorta, iliac, femoral, popliteal, or tibial arteries. 17The underlying mechanisms responsible for the functional limitations in PAD are hemodynamic in origin, which affects the supply of oxygen and substrates to metabolically active tissue: skeletal muscle in the case of intermittent claudication and skin and subcutaneous tissues in the case of critical leg ischemia. However, additional pathophysiologic mechanisms contribute to the limb manifestations, where a reduction in blood flow alone does not fully account for the exercise limitation. Recent research into the pathophysiology of this exercise limitation has identified several important sequelae resultant from the chronic hemodynamic deficit. These changes affecting the vasculature and skeletal muscle distal to the primary hemodynamic lesions likely contribute to the mechanisms of exercise limitation in PAD. These advances are reviewed here with an additional focus on identifying possible future therapeutic strategies. Symptomatic Manifestations and Exercise Limitations in PADIn the coronary circulation, plaque rupture leading to acute ischemic events is a common clinical presentation; in PAD, progressive atherosclerosis leading to chronic stenosis and occlusion, often in series, in the arteries supplying the lower extremities dominates the symptomatic manifestations.6 Limb SymptomsPatients with PAD may present with a range of limb symptoms. Most patients are either asymptomatic or have atypical limb symptoms during exercise, whereas only a third have typical symptoms of c...

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Section: Skeletal Muscle Metabolic Abnormalitiesmentioning

confidence: 99%

Pathogenesis of the Limb Manifestations and Exercise Limitations in Peripheral Artery Disease

Hiatt¹,

Armstrong²,

Larson³

et al. 2015

Circulation Research

137

118

View full text Add to dashboard Cite

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“…Nutrition based therapies are not only an option for rare mitochondriopathies but also for a spectrum of ND associated with aging (Procaccio et al, 2014). Mitochondrial dysfunction and the consequential hypometabolism of the nervous system that is a part of aging can be a source and a consequence of inflammatory processes (Currais, 2015).…”

Section: Resultsmentioning

confidence: 99%

“…KD can have a profound effect on neuronal plasticity, reduces inflammation, and improves bioenergetics in the brain … (Procaccio et al, 2014). Mitochondrial function is impaired in ND -both systemically as well as in the brain (Wilkins et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

Ketogenic diet and its impact on mental processes of working population

Grom¹

2017

Zdravje Delovno Aktivne Populacije / Health of the Working-Age Population

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Introduction: Ketogenic diet has been evaluated for wide variety of conditions, although it was initially used for treatment of epilepsy. As alternative dietary pattern it can represent means of better quality of life, improved ability to work and can prevent against cognitive decline, different dementias and more serious forms of neurodegenerative diseases. Methods: This is a systematic review of available literature. Results: As energy substrates and as signaling agents, ketones are potentially usable in mitochondriopathies that come with aging and neurodegenerative diseases, or are a consequence of stroke, trauma. It has antioxidative, antiinflammatory and antiseizure properties, improves bioenergetics of the brain, neuronal plasticity and has epigenetic function. Discussion: Expansion of current nutritional knowledge might be a paradigmatic shift in understanding what is "healthy diet" in general or in terms of segments of population.

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“…Despite significant progresses in the pathophysiology of mitochondrial disease have been achieved, there is still no effective treatment. The development of new metabolic treatments will be useful not only for rare mitochondrial disorders but also for the wide spectrum of common age-related neurodegenerative diseases shown to be associated with mitochondrial dysfunction [24]. PF (Paeoniflorin), a monoterpene glycoside isolated from the aqueous extract of Radix Paeoniae Alba, is widely used in TCM for treatment of neurodegenerative disorders, such as AD and PD.…”

Section: The Potential Targets Of Chinese Medicines In the Treatment mentioning

confidence: 99%

The Potential Targets of Chinese Medicines in the Treatment of Parkinson’s Disease: Old Wine in New Bottles

Zhang¹,

Li²,

Wang³

et al. 2016

JPP

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This article systematically reviews the present research situation of the pathogenesis of PD (Parkinson's disease) and our recent research over the past decade, to discuss the potential targets of many TCM (traditional Chinese medicines) in prevention and treatment of PD, such as against oxidative stress (Astragaloside, protocatechuic aldehyde, Liu-Wei-Di-Huang), anti-apoptosis (Geniposide, Zhichan powder), improve mitochondrial function (Paeoniflorin, Da-Bu-Yin-Wan), inhibition of protein aggregation (Panax ginseng, Irisflorentin), induce autophagy (piperine, Paeoniflorin), and many other mechanisms and multiple effectiveness (Saponins, Acanthopanax). With the research and development in PD pathogenesis and clarifying the targets of a variety of traditional Chinese medicine, especially its monomeric components, the development of traditional Chinese medicine in prevention and treatment of PD will have very broad application value and prospect.

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Perspectives of drug-based neuroprotection targeting mitochondria

Cited by 72 publications

References 61 publications

Pathogenesis of the Limb Manifestations and Exercise Limitations in Peripheral Artery Disease

Pathogenesis of the Limb Manifestations and Exercise Limitations in Peripheral Artery Disease

Ketogenic diet and its impact on mental processes of working population

The Potential Targets of Chinese Medicines in the Treatment of Parkinson’s Disease: Old Wine in New Bottles

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