Perspectives of hyperpolarized noble gas MRI beyond 3He

Lilburn, David M.L.; Pavlovskaya, Galina E.; Meersmann, Thomas

doi:10.1016/j.jmr.2012.11.014

Cited by 82 publications

(74 citation statements)

References 118 publications

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“…spin-exchange optical pumping | hyperpolarized noble gas contrast agents | cryogenic separation | chemical looping combustion | pulmonary imaging T he development of hyperpolarized (hp) noble gas MRI has resulted in a number of excellent protocols to probe different structural and functional aspects of lungs in health and disease (1)(2)(3)(4)(5)(6). Technological improvements (6)(7)(8)(9)(10)(11)(12)(13)(14)(15) have enabled pulmonary hp 129 Xe MRI at high spatial resolution, thereby reducing the need for use of the scarcely available 3 He isotope.…”

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confidence: 99%

Molecular hydrogen and catalytic combustion in the production of hyperpolarized⁸³Kr and¹²⁹Xe MRI contrast agents

Rogers

Hill-Casey

Stupic

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Hyperpolarized (hp) 83 Kr is a promising MRI contrast agent for the diagnosis of pulmonary diseases affecting the surface of the respiratory zone. However, the distinct physical properties of 83 Kr that enable unique MRI contrast also complicate the production of hp 83 Kr. This work presents a previously unexplored approach in the generation of hp 83 Kr that can likewise be used for the production of hp 129 Xe. Molecular nitrogen, typically used as buffer gas in spin-exchange optical pumping (SEOP), was replaced by molecular hydrogen without penalty for the achievable hyperpolarization. In this particular study, the highest obtained nuclear spin polarizations were P = 29% for 83 Kr and P = 63% for 129 Xe. The results were reproduced over many SEOP cycles despite the laser-induced on-resonance formation of rubidium hydride (RbH). Following SEOP, the H 2 was reactively removed via catalytic combustion without measurable losses in hyperpolarized spin state of either Xe can be obtained through dynamic nuclear polarization (25) with high spin-polarization levels of up to P = 30% (26) He-N 2 mixture or pure N 2 gas. The buffer gas serves a dual purpose as it prevents destructive radiation trapping, originating from radiative electronic relaxation of rubidium (27, 28), but also causes pressure broadening of the Rb D 1 linewidth. Rubidium line broadening maximizes adsorption of laser light emitted by high-power solid devices, even if those are line narrowed. Following SEOP, hp 129

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confidence: 99%

Molecular hydrogen and catalytic combustion in the production of hyperpolarized⁸³Kr and¹²⁹Xe MRI contrast agents

Rogers

Hill-Casey

Stupic

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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“…Many current research techniques have either started to be used clinically or have the potential to enter clinical use [34]. More abundant than helium-3, xenon-129 [35,36], by virtue of its solubility, follows the gas exchange pathways in the lungs [37] providing a unique tool for direct assesment of lung ventilation/perfusion (V/Q) matching [38] and diffusion capacity.…”

Section: Mrimentioning

confidence: 99%

Functional Image-guided Radiotherapy Planning for Normal Lung Avoidance

et al. 2016

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ReuseThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND) licence. This licence only allows you to download this work and share it with others as long as you credit the authors, but you can't change the article in any way or use it commercially. More information and the full terms of the licence here: https://creativecommons.org/licenses/ Takedown If you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. 1 AbstractFor patients with lung cancer undergoing curative intent radiotherapy, functional lung imaging can be incorporated into treatment planning to modify the dose distribution within non-target volume lung by differentiation of lung regions that are functionally defective or viable. This concept of functional image-guided lung avoidance treatment planning has been investigated with several imaging modalities, primarily SPECT but also hyperpolarised gas MRI, PET and CT-based measures of lung biomechanics. Here, we review the application of each of these modalities, review practical issues of lung avoidance implementation, including image registration and the role of both ventilation and perfusion imaging, and provide guidelines for reporting of future lung avoidance planning studies.

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“…These problems can make it challenging to image gas-filled void spaces due to the very low signal-to-noise ratio (SNR) and the usually long signal-averaging times, which can be prohibitive for many clinical applications. HP noble gases [210] can be used to address these issues. However, the production of HP noble gases is relatively expensive, necessitating costly hyperpolarizer equipment.…”

Section: Gases Hyperpolarized Via Phipmentioning

confidence: 99%

“…A wide range of nuclei can be directly hyperpolarized, including 1 H, [9] 3 He, [10] 7 Li [11] , 13 C, [1c, 12] 15 N, [13] 19 F, [14] 31 P, [15] 83 Kr, [16] and 129 Xe, [4,17] among others. [18] Hyperpolarized (HP) substances are revolutionizing the fields of NMR spectroscopy and magnetic resonance imaging (MRI), because many applications that were previously impractical because of weak NMR signals (e.g. metabolites at sub-mM) are now becoming possible.…”

Section: Introductionmentioning

confidence: 99%

NMR Hyperpolarization Techniques of Gases

Barskiy

Coffey

Nikolaou

et al. 2016

Chemistry A European J

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Nuclear spin polarization can be significantly increased through the process of hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance (NMR) experiments by 4-8 orders of magnitude. Hyperpolarized gases, unlike liquids and solids, can be more readily separated and purified from the compounds used to mediate the hyperpolarization processes. These pure hyperpolarized gases enabled many novel MRI applications including the visualization of void spaces, imaging of lung function, and remote detection. Additionally, hyperpolarized gases can be dissolved in liquids and can be used as sensitive molecular probes and reporters. This mini-review covers the fundamentals of the preparation of hyperpolarized gases and focuses on selected applications of interest to biomedicine and materials science.

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Perspectives of hyperpolarized noble gas MRI beyond 3He

Cited by 82 publications

References 118 publications

Molecular hydrogen and catalytic combustion in the production of hyperpolarized⁸³Kr and¹²⁹Xe MRI contrast agents

Molecular hydrogen and catalytic combustion in the production of hyperpolarized⁸³Kr and¹²⁹Xe MRI contrast agents

Functional Image-guided Radiotherapy Planning for Normal Lung Avoidance

NMR Hyperpolarization Techniques of Gases

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Perspectives of hyperpolarized noble gas MRI beyond 3He

Cited by 82 publications

References 118 publications

Molecular hydrogen and catalytic combustion in the production of hyperpolarized83Kr and129Xe MRI contrast agents

Molecular hydrogen and catalytic combustion in the production of hyperpolarized83Kr and129Xe MRI contrast agents

Functional Image-guided Radiotherapy Planning for Normal Lung Avoidance

NMR Hyperpolarization Techniques of Gases

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Molecular hydrogen and catalytic combustion in the production of hyperpolarized⁸³Kr and¹²⁹Xe MRI contrast agents

Molecular hydrogen and catalytic combustion in the production of hyperpolarized⁸³Kr and¹²⁹Xe MRI contrast agents