2018
DOI: 10.1007/978-3-319-76887-8_44-1
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Perspectives of Microbial Metabolites as Pesticides in Agricultural Pest Management

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Cited by 9 publications
(9 citation statements)
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“…Avermectin generally works by preventing the transmission of electrical impulses in the muscles and nerves of invertebrates by amplifying the glutamate effects on the invertebrates-specific gated chloride channel [ 50 , 51 ]. This allows more chloride ions to enter the cells, causing hyperpolarization and culminating in paralysis of the invertebrate neuromuscular systems.…”
Section: Avermectin Derivatives Formulations Therapeutic and Toxmentioning
confidence: 99%
“…Avermectin generally works by preventing the transmission of electrical impulses in the muscles and nerves of invertebrates by amplifying the glutamate effects on the invertebrates-specific gated chloride channel [ 50 , 51 ]. This allows more chloride ions to enter the cells, causing hyperpolarization and culminating in paralysis of the invertebrate neuromuscular systems.…”
Section: Avermectin Derivatives Formulations Therapeutic and Toxmentioning
confidence: 99%
“…They act on insects/nematodes preventing the transmission of electrical impulses in the muscles and nerves of invertebrates and are well-known drugs and pesticides. They amplify the glutamate effects on the invertebrate-specific gated chloride channel, activate both ligand- and voltage-gated chloride channels and induce paralysis in insects [ 30 , 31 ]. Nodulisporic acid A, a natural insecticidal indole terpene isolated from an endophytic fungus, Nodulisporium sp., also inhibits only invertebrate-specific glutamate-gated chloride (Glu-Cl) channels [ 32 ].…”
Section: Insect Ion Channel Modulatorsmentioning
confidence: 99%
“…These biological compounds are based on microorganisms (bacteria, fungi, virus or protozoa) and have been considered ecofriendly due to their speci city, low toxicity, fast decomposition and e cacy when used in low concentrations (Gupta and Dikshit 2010;Kandpal 2014;EPA 2016). Therefore, they are considered safe to non-target organisms and humans (Mazid et al 2011;Subbanna et al 2019). Due to all their advantages and safety perception by consumers, the demand of microbiological products increased over the last 5 years showing a global market value of and US $ 5.2 billion in 2020 in opposition to US $ 2.3 billion in 2015 (Kumar 2015).…”
Section: Introductionmentioning
confidence: 99%