Perspectives of molecular and nanostructured systems with d- and f-block metals in photogeneration of reactive oxygen species for medical strategies

Kuncewicz, Joanna; Dąbrowski, Janusz; Kyzioł, Agnieszka; Brindell, Małgorzata; Łabuz, Przemysław; Mazuryk, Olga; Macyk, Wojciech; Stochel, Grażyna

doi:10.1016/j.ccr.2019.07.009

Cited by 26 publications

(13 citation statements)

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“…In addition, redox-active metals catalyze the Fenton reaction, which results in the formation of reactive oxygen species (ROS) capable of oxidizing proteins, lipids, and nucleic acids. 25 , 48 , 49 Metal complexes can simultaneously exhibit several of the mechanisms of action mentioned above, and additionally combine them with the ligands' activity. 50 , 51 , 52 Due to the synergism of action of the antibiotic and desired metal ions, complexes obtained in this way often show enhanced antimicrobial activity compared to the antibiotic alone.…”

Section: Alternative Methods For Controlling Bacterial Infectionsmentioning

confidence: 99%

Photodynamic inactivation (PDI) as a promising alternative to current pharmaceuticals for the treatment of resistant microorganisms

Pucelik

Dąbrowski

2022

Advances in Inorganic Chemistry

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Although the whole world is currently observing the global battle against COVID-19, it should not be underestimated that in the next 30 years, approximately 10 million people per year could be exposed to infections caused by multi-drug resistant bacteria. As new antibiotics come under pressure from unpredictable resistance patterns and relegation to last-line therapy, immediate action is needed to establish a radically different approach to countering resistant microorganisms. Among the most widely explored alternative methods for combating bacterial infections are metal complexes and nanoparticles, often in combination with light, but strategies using monoclonal antibodies and bacteriophages are increasingly gaining acceptance. Photodynamic inactivation (PDI) uses light and a dye termed a photosensitizer (PS) in the presence of oxygen to generate reactive oxygen species (ROS) in the field of illumination that eventually kill microorganisms. Over the past few years, hundreds of photomaterials have been investigated, seeking ideal strategies based either on single molecules (e.g., tetrapyrroles, metal complexes) or in combination with various delivery systems. The present work describes some of the most recent advances of PDI, focusing on the design of suitable photosensitizers, their formulations, and their potential to inactivate bacteria, viruses, and fungi. Particular attention is focused on the compounds and materials developed in our laboratories that are capable of killing in the exponential growth phase (up to seven logarithmic units) of bacteria without loss of efficacy or resistance, while being completely safe for human cells. Prospectively, PDI using these photomaterials could potentially cure infected wounds and oral infections caused by various multidrug-resistant bacteria. It is also possible to treat the surfaces of medical equipment with the materials described, in order to disinfect them with light, and reduce the risk of nosocomial infections.

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Section: Alternative Methods For Controlling Bacterial Infectionsmentioning

confidence: 99%

Photodynamic inactivation (PDI) as a promising alternative to current pharmaceuticals for the treatment of resistant microorganisms

Pucelik

Dąbrowski

2022

Advances in Inorganic Chemistry

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“…In some cases the production of ROS by gold nanostructures themselves has been reported, even when the mechanisms are not fully understood and are currently an open topic. [81][82][83] PSs can be incorporated into the gold nanostructure by either a non-covalent interaction (based on ionic, electrostatic or hydrophobic forces) or by forming covalent bonds with the Au surface, usually using thiolated linkers. The formation of N-bonds with the Au surface has also been described.…”

Section: A Inorganic-based Nanostructuresmentioning

confidence: 99%

Photodynamic therapy: photosensitizers and nanostructures

Escudero

Carrillo‐Carrión

Castillejos

et al. 2021

Mater. Chem. Front.

139

102

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“…Types of photosensitizers for nucleic acid strand photocleavage and their properties are summarized in Table 1 . Other compounds, such as naphthalimides, coronene, 2-quinolinium dicarbocyanine, and Fe(II)N4Py, were introduced to visible light-induced photocleavage of DNA strands [ 41 , 42 , 43 , 44 , 45 , 46 ].…”

Section: Nucleic Acid Strand Photocleavagementioning

confidence: 99%

Visible Light Photochemical Reactions for Nucleic Acid-Based Technologies

et al. 2021

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The expanding scope of chemical reactions applied to nucleic acids has diversified the design of nucleic acid-based technologies that are essential to medicinal chemistry and chemical biology. Among chemical reactions, visible light photochemical reaction is considered a promising tool that can be used for the manipulations of nucleic acids owing to its advantages, such as mild reaction conditions and ease of the reaction process. Of late, inspired by the development of visible light-absorbing molecules and photocatalysts, visible light-driven photochemical reactions have been used to conduct various molecular manipulations, such as the cleavage or ligation of nucleic acids and other molecules as well as the synthesis of functional molecules. In this review, we describe the recent developments (from 2010) in visible light photochemical reactions involving nucleic acids and their applications in the design of nucleic acid-based technologies including DNA photocleaving, DNA photoligation, nucleic acid sensors, the release of functional molecules, and DNA-encoded libraries.

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Perspectives of molecular and nanostructured systems with d- and f-block metals in photogeneration of reactive oxygen species for medical strategies

Cited by 26 publications

References 383 publications

Photodynamic inactivation (PDI) as a promising alternative to current pharmaceuticals for the treatment of resistant microorganisms

Photodynamic inactivation (PDI) as a promising alternative to current pharmaceuticals for the treatment of resistant microorganisms

Photodynamic therapy: photosensitizers and nanostructures

Visible Light Photochemical Reactions for Nucleic Acid-Based Technologies

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