Perspectives on advancing consumer product exposure models

Cowan-Ellsberry, Christina; Zaleski, Rosemary; Qian, Hua; Greggs, William; Jensen, Elke

doi:10.1038/s41370-020-0237-z

Cited by 4 publications

(5 citation statements)

References 12 publications

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“…Table 2 and Fig. 2 (and SI) present results from various studies that have compared TRA predictions with other models and/or measured data [ 3 , 7 – 9 , 11 , 16 , 31 , 32 ]. In some cases, the TRA was run with defaults; when measured data were available it was generally modified to match the exposure scenario conditions.…”

Section: Resultsmentioning

confidence: 99%

“…SI- 7.2 , S-I 7.3 TRA vs ConsExpo: Dermal – TRA highest Inhalation (mg/m 3 )- TRA highest TRA vs. Measured TRA orders of magnitude higher Cowan Ellsberry et al [ 9 ] TRA ConsExpo CEM PC3 air care instant PC8a coatings solvent rich PC35 liquid cleaner PC35 trigger spray cleaner See Figs. SI 7.4 – 7.6 Inhalation (in mg/kg/day): TRA highest Dermal (mg/kg/day): TRA highest Feld-Cook et al [ 8 ] TRA EGRET Well-Mixed-Box ConsExpo E-FAST ART (median) Data PC9 painting, latex See Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Several studies have compared consumer exposure predictions by TRA and other models [7][8][9][10][11][12]. Generally, these papers have indicated the conservative nature of the TRA tool (i.e., TRA predictions exceed others) for most scenarios evaluated.…”

Section: Introductionmentioning

confidence: 99%

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An assessment of the ECETOC TRA Consumer tool performance as a screening level tool

Zaleski¹,

Dudzina²,

Keller

et al. 2023

J Expo Sci Environ Epidemiol

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Background The European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) Targeted Risk Assessment (TRA) Consumer tool was developed to fill in a methodology gap for a high throughput, screening level tool to support industry compliance with the European Union’s Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) regulation. Objective To evaluate if the TRA Consumer tool has met its design of being a screening level tool (i.e., one which does not under-predict potential exposures). Methods The TRA Consumer tool algorithms and defaults were reviewed and performance benchmarked vs. other consumer models and/or empirical data. Findings from existing reviews of the TRA consumer tool were also considered and addressed. Results TRA predictions based on its default inputs exceeded measured exposures when available, typically by orders of magnitude, and were generally greater than or similar to those of other consumer exposure tools. For dermal exposure from articles, there was no evidence that a diffusivity approach would provide more appropriate exposure estimates than those of the TRA. When default values are refined using more specific data, the refined values must be considered holistically to reflect the situation being modeled as some parameters may be correlated. Significance This is the first evaluation of the ECETOC TRA consumer tool in its entirety, considering algorithms, input defaults, and associated predictions for consumer products and articles. The evaluation confirmed its design as a screening level tool. Impact Statement The ECETOC TRA Consumer tool has been widely applied to generate exposure estimates to support chemical registrations under the EU REACH regulation. This evaluation supports the appropriateness of the TRA as a screening level exposure assessment tool. It also warrants additional measurements of consumer exposure, especially for article use scenarios, to aid the development of consumer exposure tools and chemical risk assessment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

An assessment of the ECETOC TRA Consumer tool performance as a screening level tool

Zaleski¹,

Dudzina²,

Keller

et al. 2023

J Expo Sci Environ Epidemiol

Self Cite

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show abstract

“…Rapid risk-based prioritization of large numbers of chemicals in numerous building materials, consumer products, and consumer articles used indoors (here collectively referred to as sources) has become an increasing focus of chemical management strategies to protect humans from potentially harmful exposures. − Although these strategies emphasize the need for high-quality, representative exposure data and mechanistic (i.e., process-based) exposure models, approaches for implementation are highly fragmented among countries, authorities, and research institutions. , We need to implement more efficiently the current understanding of fundamental mechanisms governing indoor exposure to chemicals released from sources. This is especially true for semivolatile organic compounds (SVOCs) due to their multimedia behavior.…”

Section: Introductionmentioning

confidence: 99%

“…1−5 Although these strategies emphasize the need for high-quality, representative exposure data and mechanistic (i.e., process-based) exposure models, approaches for implementation are highly fragmented among countries, authorities, and research institutions. 5,6 We need to implement more efficiently the current understanding of fundamental mechanisms governing indoor exposure to chemicals released from sources. This is especially true for semivolatile organic compounds (SVOCs) due to their multimedia behavior.…”

Section: ■ Introductionmentioning

confidence: 99%

Assessing Human Exposure to SVOCs in Materials, Products, and Articles: A Modular Mechanistic Framework

Eichler

Hubal

et al. 2020

Environ. Sci. Technol.

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A critical review of the current state of knowledge of chemical emissions from indoor sources, partitioning among indoor compartments, and the ensuing indoor exposure leads to a proposal for a modular mechanistic framework for predicting human exposure to semivolatile organic compounds (SVOCs). Mechanistically consistent source emission categories include solid, soft, frequent contact, applied, sprayed, and high temperature sources. Environmental compartments are the gas phase, airborne particles, settled dust, indoor surfaces, and clothing. Identified research needs are the development of dynamic emission models for several of the source emission categories and of estimation strategies for critical model parameters. The modular structure of the framework facilitates subsequent inclusion of new knowledge, other chemical classes of indoor pollutants, and additional mechanistic processes relevant to human exposure indoors. The framework may serve as the foundation for developing an open-source community model to better support collaborative research and improve access for application by stakeholders. Combining exposure estimates derived using this framework with toxicity data for different end points and toxicokinetic mechanisms will accelerate chemical risk prioritization, advance effective chemical management decisions, and protect public health.

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Accessible methods and tools to estimate chemical exposure in humans to support risk assessment: A systematic scoping review

Kalyva,

Vist,

Diemar

et al. 2024

Environmental Pollution

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Perspectives on advancing consumer product exposure models

Cited by 4 publications

References 12 publications

An assessment of the ECETOC TRA Consumer tool performance as a screening level tool

An assessment of the ECETOC TRA Consumer tool performance as a screening level tool

Assessing Human Exposure to SVOCs in Materials, Products, and Articles: A Modular Mechanistic Framework

Accessible methods and tools to estimate chemical exposure in humans to support risk assessment: A systematic scoping review

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