Perspectives on cervical cancer screening and prevention: challenges faced by providers and patients along the Texas–Mexico border

Boom, Katja; Lopez, Melissa; Daheri, Maria; Gowen, Rose; Milbourne, Andrea; Toscano, Paul A.; Carey, Cornelia; Guerra, Luca; Carvajal, JM; Marín, E.; Baker, Ellen; Fisher‐Hoch, Susan P.; Rodrı́guez, Ana M.; Burkalter, N.; Cavazos, B.; Gasca, María Luisa Rascón; Cuellar, M. M.; Robles, Elías; López, Ellen D. S.; Schmeler, Kathleen M.

doi:10.1177/1757913918793443

Cited by 34 publications

(32 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When compared to the same strategy starting at 30 years of age, starting at 25 years of age resulted in much higher detection of CIN3+. Still progression to cancer is uncommon, so It is unclear that the identification of these women with CIN3+ would translate into a meaningful reduction of cervical cancer [ 23 ]. Furthermore, the panel had concerns regarding the potential harms of beginning primary hrHPV screening at age 25 years, particularly with regard to the number of colposcopies, despite the increased detection of disease [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Co-infection with trichomonas vaginalis increases the risk of cervical intraepithelial neoplasia grade 2–3 among HPV16 positive female: a large population-based study

et al. 2020

View full text Add to dashboard Cite

Background: Evidence suggested that vaginal microbiome played a functional role in the progression of cervical lesions in female infected by HPV. This study aimed at evaluating the influence of common vaginal infection on the carcinogenicity of high risk HPV (hr-HPV). Methods: From January 15, 2017 to December 31, 2017, 310,545 female aged at least 30 years old had been recruited for cervical cancer screening from 9 clinical research centers in Central China. All the recruited participants received hr-HPV genotyping for cervical cancer screening and vaginal microenvironment test by a high vaginal swab. Colposcopy-directed biopsy was recommended for female who were infected with HPV 16 and HPV 18, and other positive hr-HPV types through test had undertaken triage using liquid-based cytology, cases with the results ≥ ASCUS among them were referred to colposcopy directly, and cervical tissues were taken for pathology examination to make clear the presence or absence of other cervical lesions. Results: Among 310,545 female, 6067 (1.95%) were tested with positive HPV 16 and HPV 18, 18,297 (5.89%) were tested with other positive hr-HPV genotypes, cervical intraepithelial neoplasia (CIN) 1, CIN 2, CIN 3 and invasive cervical cancer (ICC) were detected in 861 cases, 377 cases, 423 cases, and 77 cases, respectively. Candida albicans and Gardnerella were not associated with the detection of cervical lesions. Positive trichomonas vaginitis (TV) was correlated with hr-HPV infection (p < 0.0001). Co-infection with TV increased the risk of CIN 1 among female infected with hr-HPV (OR 1.18, 95% CI: 1.42-2.31). Co-infection with TV increased the risk of CIN 2-3 among female infected with HPV 16 (OR 1.71, 95% CI: 1.16-2.53). Conclusions: Co-infection of TV and HPV 16 is a significant factor for the detection of cervical lesions.

show abstract

Section: Discussionmentioning

confidence: 99%

Co-infection with trichomonas vaginalis increases the risk of cervical intraepithelial neoplasia grade 2–3 among HPV16 positive female: a large population-based study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Cervical carcinoma (CC) is the second most common malignant tumor in females. 1 CC is mainly caused by human papillomavirus (HPV) infection. Upon HPV infection, E6 and E7 oncoproteins begin to express and regulate downstream gene expressions, thus contributing to continuous cell proliferation to malignant transformation.…”

Section: Introductionmentioning

confidence: 99%

<p>LncRNA SNHG7 Functions as an Oncogene in Cervical Cancer by Sponging miR-485-5p to Modulate JUND Expression</p>

Zhao¹,

Zhang²,

Long³

et al. 2020

OTT

View full text Add to dashboard Cite

Background: Long non-coding RNA (LncRNA) SNHG7 is involved in the development of multiple cancers. However, its role in cervical cancer (CC) has not been elucidated. This study aimed to explore the function of SNHG7 in CC progression and the underlying mechanisms. Materials and Methods: The expression levels of SNHG7 and miR-485-5p in CC tissues and cell lines were measured by qPCR. Functional experiments including CCK-8 assay, wound healing assay, transwell assay, flow cytometry, Western blot, luciferases reporter assay and immunoprecipitation (RIP) were performed to explore the SNHG7/miR-485-5p/JUND pathway. Additionally, in vivo study was carried out by establishing tumor xenograft models. Results: We found that SNHG7 was markedly enhanced in CC tissues and cell lines, and associated with poor clinical characteristics. In vitro, knockdown of SNHG7 inhibited CC cell proliferation, migration and invasion, as well as aggravated cell apoptosis. As to mechanism investigation, rescue experiments revealed that miR-485-5p inhibitor could partially reverse the effects on CC cells induced by SNHG7 knockdown. SNHG7 upregulated JUND expression via miR-485-5p. Moreover, tumor xenograft models were established to confirm the findings in vivo. Conclusion: SNHG7 promoted CC progression through miR-485-5p/JUND axis. The SNHG7/miR-485-5p/JUND pathway might provide a novel therapeutic target for CC treatment.

show abstract

“…When compared to the same strategy starting at 30 years of age, starting at 25 years of age resulted in much higher detection of CIN3+. Still progression to cancer is uncommon, so It is unclear that the identi cation of these women with CIN3+ would translate into a meaningful reduction of cervical cancer [23] . Furthermore, the panel had concerns regarding the potential harms of beginning primary hrHPV screening at age 25 years, particularly with regard to the number of colposcopies, despite the increased detection of disease [24] .…”

Section: Discussionmentioning

confidence: 99%

Co-infection with trichomonas vaginalis increases the risk of cervical intraepithelial neoplasia grade 2-3 among HPV16 positive female: a large population-based study.

Yang

Jiang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Evidence suggested that vaginal microbiome played a functional role in the progression of cervical lesions in female infected by HPV. This study aimed at evaluating the influence of common vaginal infection on the carcinogenicity of high risk HPV (hr-HPV). Methods: From January 15, 2017 to December 31, 2017, 310,545 female aged at least 30 years old had been recruited for cervical cancer screening from 9 clinical research centers in Central China. All the recruited participants received hr-HPV genotyping for cervical cancer screening and vaginal microenvironment test by a high vaginal swab. Colposcopy-directed biopsy was recommended for female who were infected with HPV 16 and HPV 18, and other positive hr-HPV types through test had undertaken triage using liquid-based cytology, cases with the results ≥ ASCUS among them were referred to colposcopy directly, and cervical tissues were taken for pathology examination to make clear the presence or absence of other cervical lesions.Results: Among 310,545 female, 6,067 (1.95%) were tested with positive HPV 16 and HPV 18, 18,297 (5.89%) were tested with other positive hr-HPV genotypes, cervical intraepithelial neoplasia (CIN) 1, CIN 2, CIN 3 and invasive cervical cancer (ICC) were detected in 861 cases, 377 cases, 423 cases, and 77 cases, respectively. Candida albicans and Gardnerella were not associated with the detection of cervical lesions. Positive trichomonas vaginitis (TV) was correlated with hr-HPV infection (p<0.0001). Co-infection with TV increased the risk of CIN 1 among female infected with hr-HPV (OR 1.18, 95% CI: 1.42-2.31). Co-infection with TV increased the risk of CIN 2-3 among female infected with HPV 16 (OR 1.71, 95% CI: 1.16-2.53).Conclusions: Co-infection of TV and HPV 16 is a significant factor for the detection of cervical lesions.

show abstract

Perspectives on cervical cancer screening and prevention: challenges faced by providers and patients along the Texas–Mexico border

Cited by 34 publications

References 26 publications

Co-infection with trichomonas vaginalis increases the risk of cervical intraepithelial neoplasia grade 2–3 among HPV16 positive female: a large population-based study

Co-infection with trichomonas vaginalis increases the risk of cervical intraepithelial neoplasia grade 2–3 among HPV16 positive female: a large population-based study

<p>LncRNA SNHG7 Functions as an Oncogene in Cervical Cancer by Sponging miR-485-5p to Modulate JUND Expression</p>

Co-infection with trichomonas vaginalis increases the risk of cervical intraepithelial neoplasia grade 2-3 among HPV16 positive female: a large population-based study.

Contact Info

Product

Resources

About