The integration of Machine Learning (ML) into healthcare informatics holds immense promise, revolutionizing patient care and treatment strategies. However, as this technology advances, it brings forth ethical challenges crucial for careful navigation. ML offers unprecedented abilities to analyze vast healthcare data, leading to personalized medicine and improved outcomes. Yet, ethical concerns emerge, notably in privacy protection, algorithm bias, transparency, informed consent, and data quality. Transparency, explainability, and patient autonomy in decision-making processes are crucial to foster trust and accountability. Striking a balance between innovation and compliance, ensuring data quality, and promoting human-AI collaboration are essential. Addressing these challenges demands adherence to ethical frameworks, continuous monitoring, multidisciplinary governance, education, and regulatory compliance. To fully harness ML's potential in healthcare while upholding ethical standards, collaboration among stakeholders is imperative, ensuring patient welfare remains central amid technological advancements. Ethical considerations must be embedded at every stage of ML implementation to maintain an ethical, equitable, and patient-centered healthcare system.