Perspectives on Interval Exercise Interventions for Non-Alcoholic Fatty Liver Disease

Hamasaki, Hidetaka

doi:10.3390/medicines6030083

Cited by 14 publications

(10 citation statements)

References 31 publications

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“…The exercise program should be tailored to a patient's preference and capacity, depending on physical fitness level, stage of the liver disease, and other comorbidities. High-intensity interval training (HIIT) is an attractive exercise modality for treating patients with NAFLD, especially those who lack time to exercise, while it reduces visceral adipose tissue, intrahepatic fat, and fibrosis ( 47 ). General recommendations include 150 min of weekly accumulated moderate-intensity aerobic exercise, accompanied by strength and endurance training at least two to three times weekly, avoiding consecutive days and including 8–10 exercises using the major muscle groups, with 10–15 repetitions in a moderate to high intensity.…”

Section: Recommendations For Physical Activity In the Nafld Patientsmentioning

confidence: 99%

NAFLD and Physical Exercise: Ready, Steady, Go!

et al. 2021

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Along with the increase in obesity and type 2 diabetes, the non-alcoholic fatty liver disease (NAFLD) incidence is escalating, thus becoming a leading cause of liver cirrhosis and a significant burden of liver-related outcomes. Since there is no pharmacotherapy available to address the NAFLD, the most effective solutions seem to be lifestyle changes centered on physical activity. Exercise could mediate its beneficial effects directly on the liver and indirectly via extrahepatic pathways, forming a dose-response relationship with NAFLD in terms of prevalence and disease severity. Health-enhancing physical activity (HEPA) levels are mainly needed to exert beneficial effects in obese subjects, while even a small amount of exercise can be beneficial for lean individuals to prevent NAFLD. This mini-review addresses three major points regarding physical activity and NAFLD: prevention, treatment, and extrahepatic benefits, offering recommendations on type and intensity of exercise in liver disease.

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Section: Recommendations For Physical Activity In the Nafld Patientsmentioning

confidence: 99%

NAFLD and Physical Exercise: Ready, Steady, Go!

et al. 2021

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“…However, other liver enzymes did not significantly differ between CSO and placebo groups (21). A previous narrative review reported that improvement in hepatic steatosis and liver function following HIIT was associated with improved liver mitochondrial function, increased hepatic PPAR-α, and PPAR-γ content, improved insulin sensitivity, and suppression of hepatic de novo lipogenesis (76). The cellular mechanisms responsible for the positive effects of CSO on liver function have not been fully elucidated.…”

Section: Discussionmentioning

confidence: 91%

The effects of camelina sativa oil and high-intensity interval training on liver function and metabolic outcomes in male type 2 diabetic rats

Kavyani

Dehghan²,

Khani³

et al. 2023

Front. Nutr.

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ObjectivesThe purpose of this study was to evaluate the independent and combined effects of camelina sativa oil and high-intensity interval training (HIIT) on liver function, and metabolic outcomes in streptozotocin-induced diabetic rats.MethodsForty male Wistar rats were randomly assigned to five equal groups (8 per group): Normal control (NC), diabetic control (DC), diabetic + camelina sativa oil (300 mg/kg by oral gavage per day; D + CSO), diabetic + HIIT (running on a treadmill 5 days/week for 8 weeks; D + HIIT), diabetic + camelina sativa oil + HIIT (D + CSO + HIIT).ResultsIn all three intervention groups (D + CSO, D + HIIT, and D + CSO + HIIT) compared to the DC, hepatic TNF-α, MDA, and histopathology markers, decreased and hepatic PGC-1α, and PPAR-γ increased (p < 0.05). However, the effect of D + CSO was greater than D + HIIT alone. Hepatic TG decreased significantly in D + HIIT and D + CSO + HIIT compared to other groups (p < 0.001). Fasting plasma glucose in all three intervention groups (D + CSO, D + HIIT, and D + CSO + HIIT) and HOMA-IR in D + CSO and D + CSO + HIIT were decreased compared to DC (p < 0.001). Only hepatic TAC and fasting plasma insulin remained unaffected in the three diabetic groups (p < 0.001). Overall, D + CSO + HIIT had the largest effect on all outcomes.ConclusionsAt the doses and treatment duration used in the current study, combination of CSO and HIIT was beneficial for reducing liver function and metabolic outcomes other than CSO and HIIT alone.

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“…Exercise intervention studies in NAFLD are limited by low statistical power, and most have shown a reduction in intrahepatic triglyceride content without an improvement in liver fibrosis[ 152 , 153 ]. Few studies have shown a reduction in fibrosis, in particular, high-intensity interval training has recently been recognized as a novel exercise modality that demonstrated an improvement in liver stiffness (-16.8%), these benefits appeared to be independent of WL[ 154 , 155 ]. More evidence regarding the effect of exercise independently of the WL in fibrosis is required.…”

Section: Management Of Liver Fibrosis In Nafldmentioning

confidence: 99%

Clinical assessment and management of liver fibrosis in non-alcoholic fatty liver disease

Campos-Murguía

Ruiz-Margáin

González-Regueiro

et al. 2020

WJG

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Non-alcoholic fatty liver disease (NAFLD) is among the most frequent etiologies of cirrhosis worldwide, and it is associated with features of metabolic syndrome; the key factor influencing its prognosis is the progression of liver fibrosis. This review aimed to propose a practical and stepwise approach to the evaluation and management of liver fibrosis in patients with NAFLD, analyzing the currently available literature. In the assessment of NAFLD patients, it is important to identify clinical, genetic, and environmental determinants of fibrosis development and its progression. To properly detect fibrosis, it is important to take into account the available methods and their supporting scientific evidence to guide the approach and the sequential selection of the best available biochemical scores, followed by a complementary imaging study (transient elastography, magnetic resonance elastography or acoustic radiation force impulse) and finally a liver biopsy, when needed. To help with the selection of the most appropriate method a Fagan′s nomogram analysis is provided in this review, describing the diagnostic yield of each method and their post-test probability of detecting liver fibrosis. Finally, treatment should always include diet and exercise, as well as controlling the components of the metabolic syndrome, +/- vitamin E, considering the presence of sleep apnea, and when available, allocate those patients with advanced fibrosis or high risk of progression into clinical trials. The final end of this approach should be to establish an opportune diagnosis and treatment of liver fibrosis in patients with NAFLD, aiming to decrease/stop its progression and improve their prognosis.

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Perspectives on Interval Exercise Interventions for Non-Alcoholic Fatty Liver Disease

Cited by 14 publications

References 31 publications

NAFLD and Physical Exercise: Ready, Steady, Go!

NAFLD and Physical Exercise: Ready, Steady, Go!

The effects of camelina sativa oil and high-intensity interval training on liver function and metabolic outcomes in male type 2 diabetic rats

Clinical assessment and management of liver fibrosis in non-alcoholic fatty liver disease

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