Perspectives on Multiscale Colloid-Based Materials for Biomedical Applications

Abstract

Colloid-based materials with tunable biophysical and chemical properties have demonstrated significant potential in a wide range of biomedical applications. The ability to manipulate these properties across various size scales, encompassing nano-, micro-, and macrodomains, is essential to enhancing current biomedical technologies and facilitating the development of novel applications. Focusing on material design, we explore various synthetic colloid-based materials at the nano- and microscales and investigate their correlation with biological systems. Furthermore, we examine the utilization of the self-assembly of colloids to construct monolithic and macroscopic materials suitable for biointerfaces. By probing the potential of spatial imaging and localized drug delivery, enhanced functionality, and colloidal manipulation, we highlight emerging opportunities that could significantly advance the field of colloid-based materials in biomedical applications.

Criteria of Distribution Transitions in Dispersed Multiphase Systems Based on an Extended Lattice Model

“…Dispersed multiphase systems are mixtures consisting of immiscible phases with at least one component existing as a discrete phase. , These mixtures are ubiquitous in biological systems, energy industries, and medical science. − The distribution of the dispersed components in mixtures, such as blood cells and platelets in human blood, nanoparticles in nanofluids, and nanomicelles in nanoemulsions is influential in the human’s cardiovascular system, oil recovery efficiency, , and dermatological treatment . Among various distributions of dispersed particles, agglomeration, adsorption, and extraction at interfaces of immiscible fluids have garnered increased interest among researchers. − The stability of nanofluids is the crucial premise for its various industrial applications, which depends on the agglomeration propensity of nanoparticles , and could be affected by pH values of base fluids, particle concentration, and particle size .…”