2020
DOI: 10.1002/edm2.184
|View full text |Cite
|
Sign up to set email alerts
|

Perspectives on youth‐onset nonalcoholic fatty liver disease

Abstract: Nonalcoholic fatty liver disease (NAFLD) is becoming increasingly well-known for being the most common chronic liver disease in the world. While NAFLD has been documented across the full lifespan, from newborn to those advanced in age, the increase in children with NAFLD is of particular concern. Prior studies suggest that youth with NAFLD exhibit a more progressive form of the disease, including increased fibrosis, compared to adults with

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
5

Citation Types

1
41
0
4

Year Published

2021
2021
2024
2024

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 38 publications
(46 citation statements)
references
References 133 publications
(205 reference statements)
1
41
0
4
Order By: Relevance
“…Non-alcoholic fatty liver disease (NAFLD) has become the most common form of chronic liver disease in children and adolescents globally in recent years [ 1 ]. NAFLD in children is a major risk factor for the development of cirrhosis and hepatocellular carcinoma in adult [ 2 , 3 ], and it is also an early predictor of hypertension and type 2 diabetes [ 4 , 5 ]. Pregnancy is a critical period for fetal organ development [ 6 ], and maternal diet during pregnancy plays an important role in protecting against or exacerbating the offspring’s risk of developing NAFLD [ 7 , 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…Non-alcoholic fatty liver disease (NAFLD) has become the most common form of chronic liver disease in children and adolescents globally in recent years [ 1 ]. NAFLD in children is a major risk factor for the development of cirrhosis and hepatocellular carcinoma in adult [ 2 , 3 ], and it is also an early predictor of hypertension and type 2 diabetes [ 4 , 5 ]. Pregnancy is a critical period for fetal organ development [ 6 ], and maternal diet during pregnancy plays an important role in protecting against or exacerbating the offspring’s risk of developing NAFLD [ 7 , 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…Non-alcoholic fatty liver disease (NAFLD) represents a heterogeneous and progressive condition with a major pathogenic interplay between both metabolic (e.g., obesity, insulin resistance) and genetic (e.g., PNPLA3 and TM6SF2) factors [ 1 ]. Parallel to the rising trend in obesity and diabetes, it has been increasingly recognized as the most common chronic liver disease both in adults and children, representing an enormous global health concern due to its cardiometabolic burden [ 2 , 3 , 4 ]. Over the past 20 years, accumulating evidence has indicated NAFLD as the hepatic manifestation of a systemic metabolic disorder [ 1 , 5 ].…”
Section: Introductionmentioning
confidence: 99%
“…Of concern, several studies have linked NAFLD to cardiometabolic derangements even in childhood [6]. Despite several promising researches investigating pharmacological approaches, to date no drug therapy for NAFLD has been licensed and lifestyle interventions remain the mainstay of this treatment [3].…”
Section: Introductionmentioning
confidence: 99%
“…A recent metanalysis performed in subjects aged 1 to 19 years reported a prevalence of FL of 2.3% in normal-weight, 12.5% in overweight, and 36.1% in obese children [ 2 ]. Even if the natural history of FL in children is largely unknown and cause–effect relationships between FL and associated diseases are hard to prove with the present evidence base [ 3 ], it is reasonable to assume that FL persisting from childhood to adulthood may have harmful hepatic and extrahepatic consequences [ 4 , 5 , 6 , 7 ].…”
Section: Introductionmentioning
confidence: 99%