Perturbation of Epidermal Langerhans Cells in Immunosuppressed Human Renal Allograft Recipients

Sontheimer, Richard D.; Bergstresser, Paul R.; Gailiunas, P; Helderman, J. Harold; Gilliam, James N.

doi:10.1097/00007890-198402000-00011

Cited by 37 publications

(19 citation statements)

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“…In contrast to previous studies (25,26), we observed the same density of LC in both immunosuppressed and immunocompetent participants, which is in line with a study by Gibson et al (27). However, besides our study, only Sontheimer et al used age-matched groups (26), which is important, since LC density is reduced in aged skin (28).…”

Section: Discussionsupporting

confidence: 90%

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CD11c+ Dendritic Cells Rather than Langerhans Cells are Reduced in Normal Skin of Immunosuppressed Renal Transplant Recipients

Sandvik

Skarstein²,

Sviland³

et al. 2014

Acta Derm Venerol

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The increased risk of squamous cell carcinomas (SCC) in renal transplant recipients (RTR) is related to impaired immunosurveillance as a consequence of immunosuppressive therapy. Since dendritic cells (DC) play an important role in immunosurveillance, we investigated the quantity of DC subsets and macrophages in normal skin of RTR and immunocompetent controls by immunohistochemistry. In this comparative study Langerhans' cells (LC) were present in similar numbers in RTR and controls. The number of CD11c+ DC was significantly reduced in RTR, particularly in patients on triple treatment therapy, compared with controls. Macrophages were significantly increased. Plasmacytoid DC were not detected in normal skin. The reduced quantity of CD11c+ DC and increased number of macrophages in normal skin of immunosuppressed RTR may contribute to the increased incidence of SCC in RTR. This finding underlines the role of DC subsets in immunosurveillance, and may have implications for our understanding of the effect of immunosuppression on DC subsets.

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Section: Discussionsupporting

confidence: 90%

“…However, besides our study, only Sontheimer et al used age-matched groups (26), which is important, since LC density is reduced in aged skin (28). Furthermore, most of the studies were small, only the study by Bergfelt et al (25) and our study included a relatively large number of participants.…”

Section: Discussionmentioning

confidence: 81%

CD11c+ Dendritic Cells Rather than Langerhans Cells are Reduced in Normal Skin of Immunosuppressed Renal Transplant Recipients

Sandvik

Skarstein²,

Sviland³

et al. 2014

Acta Derm Venerol

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“…As a matter of fact, many studies suggest that systemic immunosuppressive therapies, more than presence of autoimmune disease, may facilitate proliferation of the mutated clone of epidermal cells by influencing the dynamics of epidermal growth or through compromising immunological control 9 . Immunosuppression and sunlight exposure have both been shown to decrease the density and to impair the function of epidermal Langerhans cells in human renal allograft recipients 11 . So immunosuppression probably causes a failure of Langerhans cell immunosurveillance and the consequent proliferation of the abnormal clone of keratinocytes 2…”

Section: Resultsmentioning

confidence: 99%

Disseminated Superficial Actinic Porokeratosis in a Patient With Sjögren Syndrome

Terranova

Amato

Massi

et al. 2003

Skinmed

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A 76-year-old woman presented to our department with intense itchiness, begun 3 years earlier, widespread to total body, especially to her limbs. Physical examination of the skin revealed multiple, small, brown, round lesions, with a diameter of about 2-6 mm, and a hyperpigmented, keratotic, slightly raised, palpable border. The skin within the ring was atrophic, hypopigmented, or mildly reddened. The lesions arose into atrophic skin where it was possible to observe some irregular, purpuric macules of variable size (Figures 1 and 2). Due to a previous diagnosis of necrotizing vasculitis of the legs and Sjögren syndrome, the patient was treated from 1999 with 8 mg/d prednisone and topical application of methyl-prednisolone. An incisional biopsy taken from a typical lesion of the right leg was performed.

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“…This to pography is related to a major exposure of those areas to sources of infection, and to local UV-induced immuno suppression. Sontheimer et al [12] reported a reduction in the number of Langerhans cells and their antigen-pre senting function in photoexposed skin of RTR. Viac et al [13] found a less important inflammatory infiltrate in warts and precancerous and neoplastic skin lesions of RTR in comparison with nonimmunosuppressed sub jects.…”

Section: Lesions Of Aesthetic or Functional Interestmentioning

confidence: 99%

Renal Transplantation and Skin Diseases: Review of the Literature and Results of a 5-Year Follow-Up of 285 Patients

Barba

Tessari²,

Boschiero³

et al. 1996

Nephron

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We present a review of the current literature on skin diseases in renal transplant recipients (RTR) and the results of a 5-year follow-up of 285 patients. Many skin diseases are only an aesthetic and functional cause for interest, but HPV infections and skin cancers are significantly more frequent in RTR than in immunocompetent subjects and can affect a patient’s prognosis. For this reason, we feel dermatological surveillance of RTR is necessary for early diagnosis and treatment of all high-risk lesions.

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Perturbation of Epidermal Langerhans Cells in Immunosuppressed Human Renal Allograft Recipients

Cited by 37 publications

References 0 publications

CD11c+ Dendritic Cells Rather than Langerhans Cells are Reduced in Normal Skin of Immunosuppressed Renal Transplant Recipients

CD11c+ Dendritic Cells Rather than Langerhans Cells are Reduced in Normal Skin of Immunosuppressed Renal Transplant Recipients

Disseminated Superficial Actinic Porokeratosis in a Patient With Sjögren Syndrome

Renal Transplantation and Skin Diseases: Review of the Literature and Results of a 5-Year Follow-Up of 285 Patients

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