Perturbations biologiques au cours du paludisme: à propos de trente cas

Abstract

L’infection palustre est une parasitose qui s’accompagne assez fréquemment de perturbations hématologiques et biochimiques. Quoique non spécifiques, ces signes biologiques peuvent être évocateurs du paludisme chez des patients ayant séjourné en zone d’endémie et présentant des signes cliniques de la maladie. Nous avons essayé à travers cette étude d’apprécier la fréquence de ces perturbations chez une série de cas avec paludisme d’importation. Nous avons analysé la NFS, le bilan lipidique, la CRP et la LDH chez une série de 30 cas de paludisme. La thrombopénie était présente chez 90% des cas (n=27) et l’anémie chez 23% des cas (n=7). La CRP était augmentée chez tous les cas. L’hypocholestérolémie était chez 80% des cas (n=24), l’hypoHDLémie chez 93,3% des cas (n=28), l’hypertriglycéridémie chez 36,6% (n=11) et la LDH était élevée chez 53,3% des cas (n=16). Ainsi, devant une suspicion d’infection palustre avec un examen direct négatif, la présence associée de ces perturbations biologiques augmenterait la probabilité diagnostique en faveur du paludisme.Malaria infection is a parasitic disease often associated with hematological and biological disturbances. Although not specific, these biological signs may be suggestive of malaria in patients who stayed in endemic areas and showing clinical signs of the disease. Our study aimed to assess the frequency of these disturbances in a series of cases with imported malaria. We analyzed NFS, the lipid profile, CRP and LDH in a series of 30 cases of malaria. Thrombopenia was found in 90% of cases (n = 27) and anemia in 23% of cases (n = 7). CRP increased in all cases. Hypocholesterolemia was found in 80% of cases (n = 24), hypoHDLemia in 93.3% of cases (n = 28), hypertriglyceridemia in 36.6% (n = 11) and LDH increased in 53.3% of cases (n = 16). Thus, where there is suspicion of malaria infection with negative direct examination, the presence of both these biological disturbances would increase the diagnostic probability of malaria.

Prevalence of Coinfection Malaria-Covid-19 at the International Hospital Center of Kinshasa during the 3<sup>rd</sup> Wave of the Pandemic

“…The fact that malaria and viral pathologies such as Covid-19 lead to thrombocytopenia as described by several authors who have worked on this subject may explain the occurrence of more thrombocytopenia in Malaria-Covid-19 coinfected patients [2] [14] [15] [18].…”

“…Malaria is a parasitic disease transmitted by the bite of female Anopheles mosquito [2]. Both of these illnesses are febrile and have several common signs [3].…”

Blood Count Characteristics of Children Hospitalized in General Pediatrics at the Gabriel Touré Teaching Hospital

“…This could also be explained by the high frequency of malaria in our sample. Several series on haematological disturbances in malaria have observed thrombocytopenia in up to 50% of cases [14] [15] [16].…”

Platelets, eryptosis, amiodarone, aspirin, Artemisia

“…Similar hematological changers were found by several authors. [2][3][4][5][6][7][8][9][10][11][12] Graphical representation shows it clearly (Figure 1)(Figure 2). Figure 2 Hematological changes in P. Falciparum and P. Vivax malaria.…”