Perturbations of Adjuvant Chemotherapy on Cardiovascular Responses and Exercise Tolerance in Patients with Early-Stage Breast Cancer

Abstract

Background: Adjuvant chemotherapies are commonly used for treating early-stage breast cancer. However, whether chemotherapeutic regimens affect exercise tolerance and cardiovascular responses remains unclear. Therefore, we investigated the effects of receiving CAF and AC-T on exercise tolerance and cardiovascular responses in patients with early-stage breast cancer. Methods: Thirty-four patients with breast cancer (age: 44 ± 1 years; stage I-II) received either CAF (n = 15) or AC-T (n = 19), depending on clinical decisions. Their step-exercise tolerance and cardiovascular responses were assessed before and after chemotherapy. Results: After chemotherapy, there were no differences in baseline measurements between patients receiving CAF or AC-T. The increases in resting heart rate (RHR) of those receiving AC-T was significantly greater than that of those receiving CAF. CAF and AC-T did not result in increased pulse wave velocity (PWV), yet the subendocardial viability ratio (SEVR) in patients receiving AC-T was significantly lower than the baseline. Greater change in post-exercise heart rate recovery (recovery HR) after chemotherapy was observed in those who had received AC-T; the Recovery HR in AC-T patients was significantly higher during post-exercise period than that in CAF patients. Conclusions: AC-T chemotherapy increases RHR and impairs exercise tolerance after chemotherapy more than CAF. Moreover, AC-T also lowers myocardial perfusion more than CAF after chemotherapy.

Radial arterial waves for chemotherapy- and radiotherapy-related myocardial damage identification in patients with breast cancer

“…Chemotherapy causes heart damage, and Lin et al found that chemotherapy further limits exercise capacity in patients with early-stage breast cancer. Basic information on various cardiovascular responses to exercise after chemotherapy in patients with early breast cancer [ 32 ]. Schoffel et al also believe that chemotherapy can easily cause heart failure from the adverse effects of treatment.…”

Investigating the Impact of Eight Weeks of Aerobic Training on Liver Enzymes and Hematological Profile in Children with Leukemia

“…Most cancer patients who suffer from fatigue and muscle weakness are encouraged to rest and avoid exercise to reduce fatigue and improve pain symptoms (Courneya & Friedenreich, 2007). In recent decades, the use of exercise programs as an effective intervention to improve the quality of life of cancer patients has attracted the attention of scientists (Lin et al, 2021;Mujtaba, Mazhar, & Tanzeel, 2021). Many studies have been conducted on the effect of physical activity on various diseases (Courneya & Friedenreich, 2007) but there are limit studies about effect of physical activity on ALL.…”