Pertussis Complicated by the Syndrome of Inappropriate Antidiuretic Hormone Secretion

Matherne, Paul; Matson, James R.; Marks, Melvin I.

doi:10.1177/000992288602500109

Cited by 8 publications

(5 citation statements)

References 5 publications

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“…[12][13][14] Experimental and clinical observations have suggested that hypoxaemia and hypercapnia stimulate release of antidiuretic hormone. "In this study a large number of patients with a PaCO2 above 5-33 kPa, which can be considered as pathologically increased if tachypnoea is present, had raised antidiuretic hormone concentrations.…”

Section: Discussionmentioning

confidence: 99%

Excessive secretion of antidiuretic hormone in infections with respiratory syncytial virus.

Steensel-Moll

Hazelzet

Voort

et al. 1990

Archives of Disease in Childhood

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The association between infections with respiratory syncytial virus and plasma concentrations of antidiuretic hormone was assessed in 48 patients who had been admitted to hospital. The mean (SEM) concentration of antidiuretic hormone was significantly raised in patients with bronchiolitis (9.3 (1-4) ng/l) compared with nonpulmonary respiratory syncytial virus infections that cause apnoea or upper respiratory tract symptoms (6-1 (1-7) ng/l). The highest concentrations of antidiuretic hormone were seen in patients receiving mechanical ventilation (18-0 (6.7) ng/l). There were no differences in mean serum sodium concentrations among the subgroups. Hypertranslucency on chest radiograph or an arterial carbon dioxide tension above 6-67 kPa were associated with a significantly higher concentration of antidiuretic hormone. Increased or normal maintenance fluid intake in children with pulmonary respiratory syncytial virus infections may cause the same symptoms of fluid overload as the syndrome ofinappropriate secretion of antidiuretic hormone. Patients with pulmonary respiratory syncytial virus infection, hypertranslucency in chest radiograph, hypercapnia, or mechanical ventilation are at risk for raised concentrations of antidiuretic hormone.Restricted fluid intake and careful monitoring of fluid balance and plasma electrolyte concentrations are therefore necessary in these patients.

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Section: Discussionmentioning

confidence: 99%

Excessive secretion of antidiuretic hormone in infections with respiratory syncytial virus.

Steensel-Moll

Hazelzet

Voort

et al. 1990

Archives of Disease in Childhood

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“…The complication and indeed, a red herring in this case, of hyponatraemia has been mentioned in childhood cases secondary to SIADH,8 related to neonatal oedema9 or related to cerebral haemorrhages, disseminated intravascular coagulation and concomitant pseudomonas infection 10…”

Section: Discussionmentioning

confidence: 55%

Haemorrhage, hyponatraemia and more than just a hack

Shah

Kandil

2014

BMJ Case Reports

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A 43-year-old previously healthy solicitor presented with a 9-day history of cough productive of yellow sputum with a prodrome of sore throat and myalgia. The cough was paroxysmal in nature and severe enough to cause extensive bilateral subconjunctival haemorrhages and cough syncopes multiple times a day, with one bout of associated haematemesis on the day of admission. He was isolated, treated for a presumed atypical chest infection with tazocin and clarithromycin, and monitored carefully until the hyponatraemia on presentation was resolved. Atypical screen and blood cultures were sent off, though unexciting at first, eventually confirmed the unlikely; Bordetella pertussis, much to the surprise of many who had Legionella as the top differential.

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“…However, there has been only 1 report describing pertussis complicated with SIADH, 4 indicating that this might be a comparatively rare state. Although our case showed the atypical clinical course as pertussis, lacking the symptoms of apnea, whooping cough, and laboratory data of hyperleukocytosis especially in lymphocytes, these symptoms indicate the diagnosis in most pertussis patients and let us make early medical interventions especially in infants, resulting in the avoidance of severe complications such as pneumonia.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

“…2,3 However, there are few reports describing any association with pertussis. 4 We report on the case of a 6-week-old male infant exhibiting pertussis pneumonia with convulsive status associated with hyponatremia caused by SIADH. CASE A 6-week-old boy was admitted to the emergency department of our hospital with symptoms of lethargy and mild hypothermia, which had persisted since the morning.…”

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confidence: 99%

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Pertussis Pneumonia Complicated by a Hyponatremic Seizure

Abe¹,

Watanabe²

2003

Pediatric Emergency Care

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We present the case of a 6-week-old male infant who had a convulsion due to pertussis pneumonia. He was admitted to our emergency department because of lethargy and hypothermia. He developed a generalized tonic-clonic convulsion, requiring various treatments, including artificial ventilation. A chest CT showed bilateral pneumonia and laboratory data revealed hyponatremia with other features of the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Although SIADH has been recognized as a cause of hyponatremia in association with pneumonia, there is little in the literature regarding SIADH caused by pertussis. Hyponatremia caused by SIADH must be considered as a differential diagnosis of seizures in pertussis infection of infants.

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Pertussis Complicated by the Syndrome of Inappropriate Antidiuretic Hormone Secretion

Cited by 8 publications

References 5 publications

Excessive secretion of antidiuretic hormone in infections with respiratory syncytial virus.

Excessive secretion of antidiuretic hormone in infections with respiratory syncytial virus.

Haemorrhage, hyponatraemia and more than just a hack

Pertussis Pneumonia Complicated by a Hyponatremic Seizure

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