Pertussis outbreak detected by active surveillance in Cyprus in 2003

Theodoridou, Maria; Hadjipanagis, A.; Persianis, N.; Makri, Sotiria; Hadjichristodoulou, Christos

doi:10.2807/esm.12.05.00709-en

Cited by 11 publications

(9 citation statements)

References 7 publications

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“…Tuttavia, nonostante il raggiungimento di una copertura vaccinale estesa, la pertosse è ancora endemica (1,2,4). Questa infezione è fortemente riemersa negli ultimi dieci anni nei Paesi industrializzati e rimane la malattia meno controllata tra quelle prevenibili da vaccino nel mondo e rappresenta un problema importante nell'ambito delle malattie prevenibili da vaccinazione in diversi Paesi europei (5)(6)(7)(8)(9)(10)(11)(12)(13).…”

Section: Introduzioneunclassified

Evidence of increased circulation of Bordetella pertussis in the Italian adult population from seroprevalence data (2012–2013)

Palazzo

Carollo

Fedele

et al. 2016

Journal of Medical Microbiology

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Incidence data on pertussis cases in Italy do not show pertussis resurgence as recently described in other European countries. The aim of this study was to determine the seroprevalence of IgG antibodies to pertussis toxin (PT-IgG) in selected adult age groups, who can serve as a reservoir of Bordetella pertussis and be responsible for onward transmission to vulnerable infants. The seroprevalence of PT-IgG was studied in sera collected in 2012-2013 in three age groups: 20-29 years and 30-39 years (reproductive age), and ≥60 years. These data were compared to those from sera collected in similar age groups in 1996-1997. More than 80 % of the adult population analysed in the 2012-2013 group presented detectable levels of PT-IgG (>5 IU ml). PT-IgG titres of 50-99 IU ml, considered indicative of infection in the last few years, and PT-IgG titres of ≥100 IU ml, considered indicative of recent infection (i.e.within the last year), reached 9.1 % [95 % confidence interval (CI) 6.9-11.3‌ %; 58/639] and 5 % (95 % CI 3.3-6.7 %; 32/639) seroprevalence, respectively. Notably, the proportion of subjects with a seroprevalence indicative of recent infection increased significantly from 9.3 % (95 % CI 7.5-11.1 %; 96/1037) in 1996-1997 to 14.1 % (95 % CI 11.4-16.8 %; 90/639) in 2012-2013. Overall, our data clearly indicate a significant increase in the circulation of B. pertussis in adults in Italy; therefore, it is likely that the statutory notification system underestimates the real incidence of the disease. These findings have implications for preventive strategies.

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Section: Introduzioneunclassified

Evidence of increased circulation of Bordetella pertussis in the Italian adult population from seroprevalence data (2012–2013)

Palazzo

Carollo

Fedele

et al. 2016

Journal of Medical Microbiology

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“…However, despite the extensive vaccination, pertussis has remained endemic [1][2][3][4]. The disease has resurged in the last decade and remains the least controlled of vaccine-preventable disease worldwide [5][6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

High heterogeneity in methods used for the laboratory confirmation of pertussis diagnosis among European countries, 2010: integration of epidemiological and laboratory surveillance must include standardisation of methodologies and quality assurance

Barkoff

Mertsola

et al. 2012

Eurosurveillance

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Citation style for this article:He Q, Barkoff AM, Mertsola J, Glismann S, Bacci S, on behalf of the European Bordetella expert group (EUpertstrain), the European surveillance network for vaccine-preventable diseases (EUVAC.NET). High heterogeneity in methods used for the laboratory confirmation of pertussis diagnosis among European countries, 2010: integration of epidemiological and laboratory surveillance must include standardisation of methodologies and quality assurance .

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“…The inconsistency between routine RHMIS and outbreak data may be due to poor data recording. Maintaining high vaccine coverage is one of the most important interventions in reducing pertussis cases and consequently averting outbreaks [11,39,40]. The poor vaccine vial monitoring observed during the outbreak investigation and non-functional cold chain management system at primary health care units may have resulted in poor vaccine potency even in cases that received all doses [41,42]…”

Section: Discussionmentioning

confidence: 99%

Pertussis outbreak in Southern Ethiopia: challenges of detection, management and response

Mitiku

Argaw²,

Desta

et al. 2020

Preprint

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Background: Despite the availability of effective vaccines, pertussis remains endemic with high fatality rates in low and middle-income countries (LMIC).This study aims to describe an outbreak of pertussis in a health district of Ethiopia. The study highlights the challenges faced by the health system in identifying pertussis cases and appropriately responding to the outbreak at the district level.Methods: A descriptive cross-sectional study was conducted using data sourced from the District Public Health Emergency and Management (PHEM) surveillance service and outbreak management field reports. Stratified attack rates and fatality rates for pertussis are described. Systemic problems leading to the outbreak are explored and narrated. A modified CDC pertussis case definition was employed with a polymerase chain reaction used to confirm cases.Results: From September 2018 to January 2019, 1840 suspected, probable, and confirmed pertussis cases and six deaths were identified. Pertussis cases ranged from 1 month to 51 years in age. An outbreak occurred in 14 out of the 24 villages of Dara Malo district. The overall attack rate was 1708 per 100,000 population with a fatality rate of 3.3 per 1,000 pertussis cases. The highest attack rate of 12,689/100,000 was seen in infants. Among confirmed, probable and suspected pertussis cases, only 41.1% had completed the three-dose pertussis vaccine's primary schedule. The household survey revealed a population coverage of 73.4% and 40.8% for Pentavalent vaccine dose one and three respectively. Investigations suggested the existence of a poor cold chain management system in the study area.Conclusions: There is an urgent need to build capacity to strengthen routine vaccination services and improve the maintenance of the vaccine cold chain. Other LMICs are urged to take lessons learned from this outbreak to strengthen their own vaccination programs and capacitate health workers to manage local outbreaks.

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Pertussis outbreak detected by active surveillance in Cyprus in 2003

Cited by 11 publications

References 7 publications

Evidence of increased circulation of Bordetella pertussis in the Italian adult population from seroprevalence data (2012–2013)

Evidence of increased circulation of Bordetella pertussis in the Italian adult population from seroprevalence data (2012–2013)

High heterogeneity in methods used for the laboratory confirmation of pertussis diagnosis among European countries, 2010: integration of epidemiological and laboratory surveillance must include standardisation of methodologies and quality assurance

Pertussis outbreak in Southern Ethiopia: challenges of detection, management and response

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