Pertussis requiring intensive care

Surridge, Julia; Segedin, Elizabeth; Grant, Cameron C.

doi:10.1136/adc.2006.114082

Cited by 76 publications

(59 citation statements)

References 28 publications

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“…Hyperleukocytosis was an independent predictor of death among 13 critically ill infants with pertussis in the UK (Pierce, Klein and Peters 2000). Other studies showed that high leukocytosis was similarly predictive of death among pertussis infants in Canada (Mikelova et al 2003), New Zealand (Surridge, Segedin and Grant 2007), Argentina (Gentile et al 2014), Tunisia (Borgi et al 2014) and the USA (Murray et al 2013). Winter et al analyzed this association more closely in a larger study of fatal pertussis cases in the USA, finding that leukocytosis above 70 400 was particularly predictive of death, especially if combined with low birth weight (Winter et al 2015).…”

Section: Clinical Findings and Relationship To Fatal Pertussismentioning

confidence: 94%

Pertussis leukocytosis: mechanisms, clinical relevance and treatment

Carbonetti

2016

Pathogens and Disease

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One sentence summary: Pertussis infection in young infants is characterized by high white blood cell counts (leukocytosis) and this minireview covers the causes, clinical findings and possible treatments for pertussis leukocytosis. Editor: Patrik Bavoil ABSTRACTThe significant and sometimes dramatic rise in the number of circulating white blood cells (leukocytosis) in infants suffering from pertussis (whooping cough) has been recognized for over a century. Although pertussis is a disease that afflicts people of all ages, it can be particularly severe in young infants, and these are the individuals in whom leukocytosis is most pronounced. Very high levels of leukocytosis are associated with poor outcome in infants hospitalized with pertussis and modern treatments are often aimed at reducing the number of leukocytes. Pertussis leukocytosis is caused by pertussis toxin, a soluble protein toxin released by Bordetella pertussis during infection, but the exact mechanisms by which this occurs are still unclear. In this minireview, I discuss the history of clinical and experimental findings on pertussis leukocytosis, possible contributing mechanisms causing this condition and treatments aimed at reducing leukocytosis in hospitalized infants. Since recent studies have detailed significant associations between specific levels of pertussis leukocytosis and fatal outcome, this is a timely review that may stimulate new thinking on how to understand and combat this problem.

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Section: Clinical Findings and Relationship To Fatal Pertussismentioning

confidence: 94%

Pertussis leukocytosis: mechanisms, clinical relevance and treatment

Carbonetti

2016

Pathogens and Disease

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“…Given their increased risk of pertussis disease complications, caution in discharge planning for premature infants remains necessary, particularly if chronic lung disease is present. 18,19 In our study sample, children hospitalized with pertussis had a median of 4 inpatient days during their initial admission. This admission duration is the same as that for infants hospitalized with pertussis in the United States (1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004) and also in New Zealand during the most recent pertussis epidemic (2004-2005).…”

Section: Discussionmentioning

confidence: 99%

“…These include younger age, premature gestation, less complete immunization, intensity of exposure, receipt of macrolide antibiotics, presence of pneumonia or leukocytosis, and B pertussis serotype. 8,[14][15][16][17][18] We measured all of these except intensity of exposure and B pertussis serotype, and no associations with the readmission risk were evident. Nineteen percent of the children in this case series had a history of either low birth weight or were born prematurely.…”

Section: Discussionmentioning

confidence: 99%

When to Discharge Children Hospitalized With Pertussis?

Lurie¹,

Reed²

2009

Academic Pediatrics

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“…She required intubation and ventilation and stayed in PICU for 9 days. The study from New Zealand comparing 1992 with 2003 shows us that infants are now being treated in PICU more often (11). Out of 72 children treated in PICU with pertussis, 97% were younger than 12 months old and 81% were less than 3 months old.…”

Section: Discussionmentioning

confidence: 99%

Maternal and infant Bordetella pertussis infection

Narkevičiūtė¹,

Kavaliūnaitė²,

Janušaitienė³

2014

AML

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Background. Pertussis continues to be a public health concern around the world because of increasing morbidity among vaccinated children and adults, severe disease forms in infants and late diagnosis. It is frequently believed that pertussis is exclusively a “childhood disease”, but there have been increasing reports of B. pertussis infection among adolescents and adults, although the peak incidence and the highest mortality occur among infants. Case presentation. 7-week-old infant illness started with a dry cough, on the 8th day of her illness it became paroxysmal. The infant’s recurrent apnea episodes started on the day 12 of the illness, she started vomiting and developed severe respiratory failure. The patient required intubation and ventilation and stayed in PICU for 9 days. Blood showed lymphocytic leukocytosis. Pertussis diagnosis was confirmed by specific IgM antibody seroconversion. Disease to her 30-year-old mother began with catarrhal symptoms, later her paroxysmal coughing became accompanied by vomiting. Atypical bacterial bronchitis was suspected. Rigorous epidemiological history and detection of pertussis antibodies have helped to the confirmation of the pertussis diagnosis. The clinical course of B. pertussis infection in the infant was severe, and the mother’s course was mild. Conclusions. Our presented clinical case of the infant and her mother’s B. pertussis infection illustrates the complex diagnostic difficulties in diagnosing pertussis, requiring laboratory confirmation, analysis of epidemiological data and appropriate evaluation. Pertussis to the infant and the mother occurred with the typical three stages: catarrhal, paroxysmal and convalescente. The infant underwent a severe form of the disease, but the outcome was good. Understanding the source of pertussis may provide new approaches to preventing pertussis in the most vulnerable infants.

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Pertussis requiring intensive care

Cited by 76 publications

References 28 publications

Pertussis leukocytosis: mechanisms, clinical relevance and treatment

Pertussis leukocytosis: mechanisms, clinical relevance and treatment

When to Discharge Children Hospitalized With Pertussis?

Maternal and infant Bordetella pertussis infection

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