Pertussis seronegativity in pregnant women in the city of Al Ain, United Arab Emirates

Narchi, Hassib; Osman, Wafa; George, Junu A.; Almekhaini, Lolowa A.; Souid, Abdul‐Kader; Alsuwaidi, Ahmed R.

doi:10.1016/j.ijid.2019.08.031

Cited by 6 publications

(7 citation statements)

References 29 publications

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“…Hence, the effects of poor adult vaccine uptake rates have been masked by a young population, though not for long. As for vaccination studies, those are not extensive and deal with either specific vaccines or specific age groups; however, their results still show a lack of vaccine uptake and a high level of disease susceptibility (13)(14)(15). The UAE's national agenda specifies a wide-ranging work program centered around six national priorities, the fourth of which is a "world-class healthcare" (28).…”

Section: Discussion Adult Vaccination: the Global And Local Landscapementioning

confidence: 99%

“…Yet very few studies have looked at this in the Middle East and North Africa (MENA) region and even less locally. In the United Arab Emirates (UAE), vaccination has been an under-researched topic with only a few studies exploring specific vaccines, such as influenza or Human Papilloma Virus (HPV) (13)(14)(15). However, no studies have looked at physicians and their role in promoting general adult vaccination.…”

Section: Introductionmentioning

confidence: 99%

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Adult Vaccination in the United Arab Emirates—A Physicians' Knowledge and Knowledge Sources Study

Barqawi

Samara

Hassan

et al. 2022

Front. Public Health

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BackgroundA lack of knowledge on adult vaccination has been documented among physicians. They play a critical role in promoting adult vaccines. This study aimed to review the status of adult vaccination in the United Arab Emirates (UAE) and evaluate physicians' knowledge and knowledge sources regarding adult vaccines.MethodsLocal, regional, and global adult vaccination guidelines were reviewed. A 40-item questionnaire was used to collect data from physicians from June to October 2020, using convenience and snowball sampling. Knowledge score was calculated, and predictors identified using Mann–Whitney U and Kruskal–Wallis H-tests. Ordinary Least Squares regression was used for Multivariate Analysis.ResultsA total of 500 responses were included. A quarter were internists, and another quarter were family physicians. Fifty-seven percent were medical interns and residents. Both perceived and actual knowledge of adult vaccination were low. Bivariate analysis showed knowledge depending on department, level of training, workplace, and perceived knowledge. All remained significant after multivariable regression except workplace. International and local guidelines were the most common knowledge sources. Forty-two percent were unable to access the local guidelines.ConclusionsPhysicians' knowledge was poor and local guidelines were not clear or easily accessible. Participants were highly receptive to guidance and practice with adult vaccines.

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Section: Discussion Adult Vaccination: the Global And Local Landscapementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adult Vaccination in the United Arab Emirates—A Physicians' Knowledge and Knowledge Sources Study

Barqawi

Samara

Hassan

et al. 2022

Front. Public Health

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“…Although contact with mild or asymptomatic pertussis cases in the society may provide protective antibodies against the disease, a significant part of the society remains susceptible to the disease in adulthood as corroborated with the data presented in the previous section. [25][26][27] Studies showing immunity against pertussis in pregnant women are extremely limited in Turkey. In the study conducted by Ercan et al 19 72% of pregnant women were found to be immune to pertussis.…”

Section: Discussionmentioning

confidence: 99%

“…In studies conducted in other countries, the rates of immunity in pregnant women vary between 25% and 97.1%. 15,16,27 It is thought that this difference can be attributed to the differences in the vaccination programs, different probability of the prevalence of pertussis disease and differences in disease prevelance rates of different countries. 3,[12][13][14]16,17 Pertussis is usually diagnosed serologically or clinically.…”

Section: Discussionmentioning

confidence: 99%

Investigation of immunity against Bordetella pertussis in pregnant women and an overview of the vaccination schedule in Turkey

Gül¹,

Sönmez²,

Ayvaz³

et al. 2021

Turk J Pediatr

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Background. Pertussis caused by Bordetella pertussis, is a disease leading to significant morbidity and mortality in neonates and infants. Direct protection of the infant may be achieved by maternal and neonatal vaccination. Despite primary vaccination, infants under six months pose the greatest risk of infection with pertussis. Maternal immunization provides a high level of infant protection from birth until immunity is achieved by active vaccination. There is no routine Tdap vaccination recommendation for pregnant women in Turkey. This study was carried out to determine pertussis antibody levels in pregnant women and provide data for improving vaccine planning.Methods. The study was carried out with 133 pregnant women in Turkey. Antibody titers to pertussis toxin (anti-PT) and filamentous hemagglutinin (anti-FHA) were measured by the commercially available ELISA.Results. Among 133 participants, 93 (69.9%) were found to be immune according to anti-PT IgG antibody levels. According to anti-FHA IgG antibody levels, 123 (92.5%) participants were considered to be immune. A positive correlation was observed between PT and FHA and the findings were statistically significant (P <0.001, r = 0.343). In the study group, the ages of the participants varied between 17 and 44 years. The mean age of those who were immune was 27.3±5.6, the mean age of non-immune patients was 29.1±6.2 and the difference was not statistically significant (P= 0.14). Conclusions.Our results reveal that approximately one-third of pregnant women were not immune to pertussis, reflecting many young infants to be vulnerable to pertussis infection until the onset of primary vaccinations, although childhood pertussis vaccination coverage has been high for a long time. We conclude that Tdap vaccine recommendation for pregnant women regardless of previous immunization history may be beneficial for the protection of infants in their first six months.

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“…Despite that, PT-IgG was undetectable in 75% of pregnant women attending antenatal clinic at the Oasis hospital, Al Ain, UAE. PT-IgG geometric mean did not differ among women of different age groups [ 49 ].…”

Section: Efficacy and Effectivenessmentioning

confidence: 99%

Whole-Cell and Acellular Pertussis Vaccine: Reflections on Efficacy

et al. 2022

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Pertussis is a common respiratory infection caused by the bacterium Bordetella pertussis. Although most cases occur in developing countries, it is considered endemic globally. The World Health Organization estimates there are 20 to 40 million cases of pertussis annually. Pertussis vaccines played a pivotal role in reducing the burden of pertussis disease as well as in infant morbidity and mortality. Although the two forms of pertussis vaccine are effective, each has its advantages and drawbacks. This paper aims to review the current knowledge on pertussis vaccine, emphasizing vaccine effectiveness in different populations in a community. Clinical trials have shown favorable vaccine efficacy with acellular pertussis (aP) vaccine. However, observation and population-level studies showed that introducing at least a single dose of whole-cell pertussis (wP) vaccine within the routine immunization schedule is associated with better disease protection and a longer duration of immunity. On the other hand, wP vaccine is more reactogenic and associated with higher adverse events. Therefore, the selection of vaccine should be weighed against the effectiveness, reactogenicity, and cost-effectiveness. Due to its safety profile, aP vaccine can be offered to wider population groups. Booster adolescent and pregnant immunization programs have been implemented globally to control outbreaks and protect vulnerable infants. Due to the variable effectiveness performance of both vaccines, different countries adopted distinctive immunization programs. Determining the right vaccination approach depends on financial consideration, immunization program infrastructure, adverse event monitoring, and pertussis surveillance in the community.

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Pertussis seronegativity in pregnant women in the city of Al Ain, United Arab Emirates

Cited by 6 publications

References 29 publications

Adult Vaccination in the United Arab Emirates—A Physicians' Knowledge and Knowledge Sources Study

Adult Vaccination in the United Arab Emirates—A Physicians' Knowledge and Knowledge Sources Study

Investigation of immunity against Bordetella pertussis in pregnant women and an overview of the vaccination schedule in Turkey

Whole-Cell and Acellular Pertussis Vaccine: Reflections on Efficacy

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