Pertussis vaccination in infancy lowers the incidence of pertussis disease and the rate of hospitalisation after one and two doses: Analyses of 10 years of pertussis surveillance

Nilsson, Lennart; Lepp, Tiia; Segebaden, Kerstin Von; Hallander, Hans O.; Gustafsson, Lennart

doi:10.1016/j.vaccine.2011.10.089

Cited by 35 publications

(21 citation statements)

References 17 publications

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“…We have previously demonstrated some protection from the first dose of a pertussis vaccine, which significantly lowers incidence and hospitalisation rates in infants of the same age [18]. The present study confirms that vaccination reduces severity beyond what is attributable to age at onset of disease.…”

Section: Discussionsupporting

confidence: 85%

Surveillance of infant pertussis in Sweden 1998–2012; severity of disease in relation to the national vaccination programme

et al. 2015

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Section: Discussionsupporting

confidence: 85%

Surveillance of infant pertussis in Sweden 1998–2012; severity of disease in relation to the national vaccination programme

et al. 2015

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“…Similar to the authors' results in 7-monthold baboons, these data suggest that it is possible for the immune response to aP to prevent severe pertussis without blocking respiratory colonization. While there are no clinical efficacy data on the ability of neonatal vaccination to prevent pertussis, these findings are consistent with recent studies showing that aP vaccines reduce pertussis morbidity and hospitalization rates in infants after a single dose at 2-3 months of age [87,88].…”

Section: Identifying Vaccine Strategies To Protect Newbornssupporting

confidence: 88%

The baboon model of pertussis: effective use and lessons for pertussis vaccines

Warfel

Merkel²

2014

Expert Review of Vaccines

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The USA is experiencing a pertussis resurgence that resulted in a 60-year high of 48,000 cases in 2012. Our ability to counteract this resurgence is hampered by the fact that pertussis pathogenesis and immunity to pertussis infection are not well studied. Studies in humans are difficult due to the low frequency of pertussis in the population, the cyclical nature of incidence and the sporadic geographic distribution of cases. While existing animal models reproduce many aspects of pertussis, none of them adequately reproduces the full spectrum of disease. We describe the baboon model of pertussis. The baboon model is the first animal model that recapitulates the full spectrum of human pertussis including coughing and transmission. This model is being utilized to examine pertussis pathogenesis and host responses to infection and vaccination. It is likely the baboon model will provide an important tool in the development of improved pertussis vaccines.

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“…These data suggest that cocooning is unlikely to be an effective strategy to reduce the burden of pertussis in infants. However, it is important to note that our data in combination with human data show that vaccination with aP provides excellent protection from severe pertussis (52). Therefore, any short-term plan for addressing the resurgence of pertussis should include continued efforts to enhance aP immunization.…”

Section: Discussionmentioning

confidence: 68%

Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model

Warfel

Zimmerman

Merkel

2013

Proc. Natl. Acad. Sci. U.S.A.

539

531

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Pertussis is a highly contagious respiratory illness caused by the bacterial pathogen Bordetella pertussis. Pertussis rates in the United States have been rising and reached a 50-y high of 42,000 cases in 2012. Although pertussis resurgence is not completely understood, we hypothesize that current acellular pertussis (aP) vaccines fail to prevent colonization and transmission. To test our hypothesis, infant baboons were vaccinated at 2, 4, and 6 mo of age with aP or whole-cell pertussis (wP) vaccines and challenged with B. pertussis at 7 mo. Infection was followed by quantifying colonization in nasopharyngeal washes and monitoring leukocytosis and symptoms. Baboons vaccinated with aP were protected from severe pertussis-associated symptoms but not from colonization, did not clear the infection faster than naïve animals, and readily transmitted B. pertussis to unvaccinated contacts. Vaccination with wP induced a more rapid clearance compared with naïve and aP-vaccinated animals. By comparison, previously infected animals were not colonized upon secondary infection. Although all vaccinated and previously infected animals had robust serum antibody responses, we found key differences in T-cell immunity. Previously infected animals and wP-vaccinated animals possess strong B. pertussis-specific T helper 17 (Th17) memory and Th1 memory, whereas aP vaccination induced a Th1/Th2 response instead. The observation that aP, which induces an immune response mismatched to that induced by natural infection, fails to prevent colonization or transmission provides a plausible explanation for the resurgence of pertussis and suggests that optimal control of pertussis will require the development of improved vaccines.whooping cough | T-cell memory | animal models | adaptive immunity |

show abstract

Pertussis vaccination in infancy lowers the incidence of pertussis disease and the rate of hospitalisation after one and two doses: Analyses of 10 years of pertussis surveillance

Cited by 35 publications

References 17 publications

Surveillance of infant pertussis in Sweden 1998–2012; severity of disease in relation to the national vaccination programme

Surveillance of infant pertussis in Sweden 1998–2012; severity of disease in relation to the national vaccination programme

The baboon model of pertussis: effective use and lessons for pertussis vaccines

Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model

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