Pescadillo homologue 1 and Peter Pan function during Xenopus laevis pronephros development

Abstract

These results demonstrate that pes1 and ppan are required for Xenopus pronephros development and indicate that their function in the pronephros is independent of their role in ribosome biosynthesis.

Repression of PES1 expression inhibits growth of gastric cancer

“…Pescadillo and its homologues are also highly conserved in functions among different species. Researches have shown that pescadillo is essential for ribosome biogenesis, nucleolar assembly, DNA replication, and cell cycle progression [5][6][7][8][9][10][11][12], thereby playing crucial roles in embryonic or organic development [2,[13][14][15][16]. Knockdown or mutation of pescadillo Jieping Li and Xiaodong Zhou contributed equally to this work.…”

Transcriptome Profiling of Tiller Buds Provides New Insights into PhyB Regulation of Tillering and Indeterminate Growth in Sorghum

“…Down-regulation of both Peter pan genes (SSF1 and SSF2) in yeast leads to cell division arrest (Yu and Hirsch, 1995). In Xenopus laevis, ppan and pes1 interact and regulate ribosome biogenesis, cell proliferation, apoptosis, and gene expression (Tecza et al, 2011). Expression of PPAN and PES1 in developing pronephros is dependent on wnt4 and fzd3 function, key regulators of cell growth and cell cycle progression (Tecza et al, 2011;Pfister et al, 2015).…”

“…In Xenopus laevis, ppan and pes1 interact and regulate ribosome biogenesis, cell proliferation, apoptosis, and gene expression (Tecza et al, 2011). Expression of PPAN and PES1 in developing pronephros is dependent on wnt4 and fzd3 function, key regulators of cell growth and cell cycle progression (Tecza et al, 2011;Pfister et al, 2015). While the function of Peter pan has not been examined in plants, strong down-regulation of this gene in growth-inhibited buds of phyB-1 plants at 6 DAP, suggests that low Peter pan expression may contribute to inhibition of growth and cell division in buds of these plants.…”

Structural, biophysical and functional characterization of Nop7-Erb1-Ytm1 complex and its implications in eukaryotic ribosome biogenesis

“…Further studies showed that the gene was highly conserved in all Eukaryotes and was essential for cell viability (Kinoshita et al, 2001;Sakumoto et al, 2001). Involvement of Pes1 in embryonic development has also been shown in Xenopus laevis (Tecza et al, 2011), whereas in plants it has been correlated to root morphogenesis (Zografidis et al, 2014). In Candida albicans it was described to be important in hypha-to-yeast switch and in yeast proliferation (Shen et al, 2008).…”

“…Several binding partners of Pes1 have been described in mammalian cells including estrogen receptor (ERα and ERβ) (Cheng et al, 2012), Peter Pan (Ssf1 in yeast) (Fatica et al, 2002;Tecza et al, 2011) and B23 (Zhang et al, 2009). In a few studies, BRCT domain of Pes1 have been shown to interact with a proteinphosphatase Yvh1 and Pes1 overexpression could suppress slow-growing phenotype of Yvh1 loss-of-function (Sakumoto et al, 2001).…”