Pesticidal Activity and Mode of Action of Monoterpenes

Liu, Zhengjun; Li, Qing X; Song, Baoan

doi:10.1021/acs.jafc.2c00635

Cited by 39 publications

(30 citation statements)

References 152 publications

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“…The hypersensitivity to fragrances most frequently presents itself as allergic contact dermatitis, contact urticaria, or phototoxic reactions. These changes can take place in the skin on your hands, face, neck, or armpits [194,195].…”

Section: Allergenic Characters and Toxicity Of Eos In Cosmeticsmentioning

confidence: 99%

Role of Essential Oils and Bioactive Components for Manufacturing Cosmetic Items

Aditi¹,

Dabral²

2023

J. Res. Appl. Sci. Biotechnol.

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The cosmetics industry has been forced to search for new active chemicals as a result of increasing customer demand as well as stricter international regulations. Botanical extract offers a source of new active chemicals that is nearly endless and may be used to make cosmetics. Due to their olfactory character in the creation of fragrances and perfumes and the many beneficial properties of their individual components (EOCs), essential oils (EOs) are becoming increasingly popular natural ingredients in the cosmetics and toiletries industry. These properties include anti-inflammatory, antimicrobial, and antioxidant properties (e.g., moisturizers, lotions and cleanser in skin care cosmetics; conditioners, masks or antidandruff products in hair care products; lipsticks, or fragrances in perfumery). It is difficult to generalise the possible applications of essential oils in cosmetics and toiletries because each essential oil has its own unique chemical profile, which is connected with its own particular collection of benefits. Instead, formulators need to make an effort to discover acceptable mixes of essential oils or essential oil compounds in order to get the results they want from the completed goods. This paper presents a detailed examination of the existing research on the usage of essential oils and essential oil compounds (EOs and EOCs) in the cosmetics sector. In addition, we will focus on a few critical topics regarding the safety of essential oils and essential oil compounds used in the cosmetics sector. When formulators of cosmetics are working to perfect products that are based on botanical extracts, they are very likely to find the information offered in this review to be valuable.

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Section: Allergenic Characters and Toxicity Of Eos In Cosmeticsmentioning

confidence: 99%

Role of Essential Oils and Bioactive Components for Manufacturing Cosmetic Items

Aditi¹,

Dabral²

2023

J. Res. Appl. Sci. Biotechnol.

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“…10 Terpenes are widespread in plant secondary metabolic NPs, with α-pinene being a distinctive forest bioresource. 11,12 Agrochemical development has consistently benefited from the use of α-pinene and its derivatives. In our previous study, active pharmacophores were introduced to design and prepare several pinene-based derivatives, which exhibited improved agricultural activity.…”

Section: ■ Introductionmentioning

confidence: 99%

Discovery of Terpene-Derived Quaternary Ring Compounds Containing an Oxime Moiety as Potential Fungicides

Pan

et al. 2023

J. Agric. Food Chem.

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Terpene-derived quaternary ring compounds with an oxime moiety were designed and prepared to create fungicides from natural products. A preliminary assessment of their antifungal activity against seven common pathogenic fungi was conducted, and the median effective concentration (EC 50 ) values against Rhizoctonia solani were obtained. The effects of compound 6a 19 (3bromothiophene-containing), which had an outstanding EC 50 value (1.62 μg/mL), on the morphology, ultrastructure, reactive oxygen species production, mitochondrial membrane potential, nuclear morphology, and defense-related and respiration-related enzyme activities of mycelia were evaluated. The test compound was speculated to obstruct the bio-oxidative process, inhibiting mycelial growth. Compound 6a 19 exhibited a satisfactory in vivo control effect on leaf sheath-infected rice plants. After treating rice plants with 50, 100, and 200 μg/mL 6a 19 , the protective and therapeutic efficacy values were 48.3 and 70.3%, 58.6 and 75.7%, and 69.0 and 81.1%, respectively. Moreover, a linear quantitative structure−activity relationship (R 2 = 0.932, F = 61.3, and S 2 = 0.020) was established using density functional theory calculations. Four chemical descriptors that were crucial to the antifungal activity were analyzed: the number of occupied electronic levels of atoms, the minimum atomic orbital electronic population, maximum net atom charge for a H atom, and minimum net atomic charge. In overall consideration of experimental results, it was speculated that the target compounds satisfactorily inhibited R. solani by interfering with biological oxidation pathways, which provided an insight into the future intensive and systematic action mechanism. This research is promising for the invention of novel fungicides from natural terpenes with multiple potential targets and satisfactory ecological compatibility.

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“…Essential oil constituents such as monoterpenes have been shown to target arthropod proteins such as acetylcholinesterase (ACHE) and octopaminergic and tyraminergic receptors to induce neuromodulatory and neurotoxicity effects. − Among plant secondary metabolites, monoterpenes have been widely studied and are considered as environmentally friendly and safe alternatives to conventional synthetic insecticides . Although observed to possess biological activities with OARs and TARs, monoterpenes exhibit different pharmacological effects in different insects.…”

Section: Introductionmentioning

confidence: 99%

Specificity of Monoterpene Interactions with Insect Octopamine and Tyramine Receptors: Insights fromin SilicoSequence and Structure Comparison

et al. 2023

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Octopamine and tyramine receptors (OARs/TARs) are interesting targets for new insecticide development due to their unique roles in insects’ physiological and cellular response and their specificity to invertebrates. Monoterpene compounds that bear resemblance to the natural ligands have been shown to bind to the OARs/TARs but elicit varied responses in different insect species. Using in silico methods, we attempt to investigate the molecular basis of monoterpene interactions and their specificity in different OARs and TARs of damaging or beneficial insects. Sequence and structure comparison revealed that the OARs/TARs studied generally have more similarities in terms of structure rather than sequence identity. Together with clustering and network analyses, we also revealed that the role of IL3 might be crucial in the identification of OAR and TAR and their unique function. Among the 35 monoterpenes subjected to ensemble docking, carvacrol had the most negative average binding energies with the target insect OARs and TARs. The differences in the key interacting residues of carvacrol with insect OARs and TARs could be the origin of variation in the responses of insect species to this monoterpene. Results suggest that carvacrol may be a potential natural-product-based insecticide, targeting multiple insect pests while being nonharmful to honeybees and Asian swallowtail butterflies. This work could provide insights into the development of effective species-specific natural-product-based insecticides that are more environmentally friendly than conventional insecticides.

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Pesticidal Activity and Mode of Action of Monoterpenes

Cited by 39 publications

References 152 publications

Role of Essential Oils and Bioactive Components for Manufacturing Cosmetic Items

Role of Essential Oils and Bioactive Components for Manufacturing Cosmetic Items

Discovery of Terpene-Derived Quaternary Ring Compounds Containing an Oxime Moiety as Potential Fungicides

Specificity of Monoterpene Interactions with Insect Octopamine and Tyramine Receptors: Insights fromin SilicoSequence and Structure Comparison

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