The U.S. Geological Survey has studied the ground-water quality within two areas of the Red River of the North Basin in southeastern North Dakota and west-central Minnesota. Although both areas are underlain by sandy surficial aquifers over which intensive irrigated agriculture dominates the land use, their ground-water quality differs. Ground water from the eastern study area has significantly higher concentrations of nitrate and agricultural herbicides than does ground water from the western area. Major differences in rainfall and minor differences in soils, depth to ground water, and agricultural practices between these two areas can account for the differences measured in ground-water quality. These same factors may indicate changes in ground-water quality from agricultural land uses in other surficial aquifers in the Red River of the North Basin.