Pesticide risk assessment and management in a globally changing world—report from a European interdisciplinary workshop

Babut, Marc; Arts, G.H.P.; Caracciolo, Anna Barra; Carluer, Nadia; Domange, Nicolas; Friberg, Nikolai; Gouy, Véronique; Grung, Merete; Lagadic, Laurent; Martin-Laurent, Fabrice; Mazzella, Nicolás; Pesce, Stéphane; Real, B.; Reichenberger, Stefan; Roex, Erwin; Romijn, Kees; Röttele, Manfred; Stenrød, Marianne; Tournebize, Julien; Vernier, Françoise; Vindimian, Éric

doi:10.1007/s11356-013-2004-3

Cited by 27 publications

(15 citation statements)

References 110 publications

(125 reference statements)

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“…POPs represent a diverse group of different substances, which are toxic, semi-volatile, varied with mobility in the environment, and prone to long-range air transport on dust particles, accumulation in abiotic matrices, as well as bioaccumulation in living bodies [2,3]. This group of organic compounds, of natural or anthropogenic origin, possess a particular combination of physical and chemical properties such that, once released into the environment, they remain intact for exceptionally long periods of time, as they are resistant to photolytic, chemical and some of them on biological degradation [3][4][5][6][7]. Organochlorine pesticides (OCPs) as well as polychlorinated biphenyls (PCBs) and some polycyclic aromatic hydrocarbons (PAHs) belong to this group.…”

Section: Introductionmentioning

confidence: 99%

“…Organochlorine pesticides (OCPs) as well as polychlorinated biphenyls (PCBs) and some polycyclic aromatic hydrocarbons (PAHs) belong to this group. The OCPs are organic molecules with linked chlorine atoms, high lipophilicity and, usually, high neurotoxicity [3][4][5][6][7][8]. Examples of OCPs are chlorinated insecticides, such as dichlorodiphenyltrichloroethane (DDT), aldrin, dieldrin, heptachlor, and endrin.…”

Section: Introductionmentioning

confidence: 99%

“…Polychlorinated biphenyls (PCBs) have been widely used as dielectric and coolant fluids in electrical converters, carbonless copy paper, and in heat transfer fluids, plasticizers in paints, plastics, and rubber products [3,12]. PCBs similar to OCPs undergo long air transport and have been found in areas far from their release sources [13].…”

Section: Introductionmentioning

confidence: 99%

“…Polycyclic aromatic hydrocarbons (PAHs) are formed as unintentional substances in all combustion and pyrolysis processes of organic materials [3,12]. PAHs are released to the environment from both natural and anthropogenic sources.…”

Section: Introductionmentioning

confidence: 99%

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Residues of Persistent Organic Pollutants (POPs) in Agricultural Soils Adjacent to Historical Sources of Their Storage and Distribution—The Case Study of Azerbaijan

Ukalska‐Jaruga

Lewińska

Mammadov³

et al. 2020

Molecules

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The aim of this study was to identify and examine the levels of organochlorine pesticides (OCPs), polycyclic aromatic hydrocarbons (PAHs), and polychlorinated biphenyls (PCBs) in soil collected from the surroundings of historical pesticide storage facilities on former agricultural aerodromes, warehouses, and pesticide distribution sites located in the most important agricultural regions in Azerbaijan. The conducted research included determination of three groups of POPs (occurring together), in the natural soil environment influenced for many years by abiotic and biotic factors that could have caused their transformations or decomposition. In this study, soil samples were collected in 21 georeferenced points located in the administrative area of Bilasuvar, Saatly, Sabirabad, Salyan and Jalilabad districts of Azerbaijan. Soil chemical analysis involved determination of organochlorine compounds (OCP): hexachlorocyclohexanes (HCHs) (three isomers α-HCH, β-HCH and γ-HCH) and dichlorodiphenyltrichloroethanes (DDTs) (six congeners 2,4 DDT; 4,4 DDT; 2,4 DDE; 4,4 DDE; 2,4 DDE; and 4,4 DDE); polycyclic aromatic hydrocarbons (PAHs): 16 compounds from the United States Environmental Protection Agency US EPA list and, PCBs (seven congeners identified with the following IUPAC numbers: 28, 52, 101, 118, 138, 153, and 180). Our research showed that OCPs reached the highest concentration in the studied areas. The total concentrations of OCPs ranged from 0.01 to 21,888 mg·kg −1 with significantly higher concentrations of Σ6DDTs (0.01 µg kg −1 to 21880 mg kg −1 ) compared to ΣHCH (0.14 ng kg −1 to 166.72 µg kg −1 ). The total concentrations of PCBs in the studied soils was varied from 0.02 to 147.30 µg·kg −1 but only PCB138 and PCB180 were detected in all analyzed samples. The concentrations of Σ16 PAHs were also strongly diversified throughout the sampling areas and ranged from 0.15 to 16,026 mg kg −1 . The obtained results confirmed that the agricultural soils of Azerbaijan contained much lower (up to by three orders of magnitude) concentrations of PCBs and PAHs than DDT. It is supported by the fact that PCBs and PAHs were not directly used by agriculture sector and their content results from secondary sources, such as combustion and various industrial processes. Moreover, the high concentrations of PAHs in studied soils were associated with their location in direct neighborhood of the airport, as well as with accumulation of contaminants from dispersed sources and long range transport. The high concentrations of pesticides confirm that deposition of parent OCPs have occurred from obsolete pesticide landfills.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Residues of Persistent Organic Pollutants (POPs) in Agricultural Soils Adjacent to Historical Sources of Their Storage and Distribution—The Case Study of Azerbaijan

Ukalska‐Jaruga

Lewińska

Mammadov³

et al. 2020

Molecules

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“…While safety testing of the individual pesticides is conducted according to established regulatory guidelines (Babut et al, 2013), evaluation of the toxicity of mixtures is less structured (U.S. EPA, 2002).…”

Section: Introductionmentioning

confidence: 99%

In vitro screening for population variability in toxicity of pesticide-containing mixtures

Abdo

Wetmore

Chappell

et al. 2015

Environment International

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Population-based human in vitro models offer exceptional opportunities for evaluating the potential hazard and mode of action of chemicals, as well as variability in responses to toxic insults among individuals. This study was designed to test the hypothesis that comparative population genomics with efficient in vitro experimental design can be used for evaluation of the potential for hazard, mode of action, and the extent of population variability in responses to chemical mixtures. We selected 146 lymphoblast cell lines from 4 ancestrally and geographically diverse human populations based on the availability of genome sequence and basal RNA-seq data. Cells were exposed to two pesticide mixtures – an environmental surface water sample comprised primarily of organochlorine pesticides and a laboratory-prepared mixture of 36 currently used pesticides – in concentration response and evaluated for cytotoxicity. On average, the two mixtures exhibited a similar range of in vitro cytotoxicity and showed considerable inter-individual variability across screened cell lines. However, when in vitroto-in vivo extrapolation (IVIVE) coupled with reverse dosimetry was employed to convert the in vitro cytotoxic concentrations to oral equivalent doses and compared to the upper bound of predicted human exposure, we found that a nominally more cytotoxic chlorinated pesticide mixture is expected to have greater margin of safety (more than 5 orders of magnitude) as compared to the current use pesticide mixture (less than 2 orders of magnitude) due primarily to differences in exposure predictions. Multivariate genome-wide association mapping revealed an association between the toxicity of current use pesticide mixture and a polymorphism in rs1947825 in C17orf54. We conclude that a combination of in vitro human population-based cytotoxicity screening followed by dosimetric adjustment and comparative population genomics analyses enables quantitative evaluation of human health hazard from complex environmental mixtures. Additionally, such an approach yields testable hypotheses regarding potential toxicity mechanisms.

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Land Use Change and Health

Pan

Bonnet

2022

International Handbook of Population and Environment

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Pesticide risk assessment and management in a globally changing world—report from a European interdisciplinary workshop

Cited by 27 publications

References 110 publications

Residues of Persistent Organic Pollutants (POPs) in Agricultural Soils Adjacent to Historical Sources of Their Storage and Distribution—The Case Study of Azerbaijan

Residues of Persistent Organic Pollutants (POPs) in Agricultural Soils Adjacent to Historical Sources of Their Storage and Distribution—The Case Study of Azerbaijan

In vitro screening for population variability in toxicity of pesticide-containing mixtures

Land Use Change and Health

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