Pesticides and Breast Cancer Risk: A Review of DDT, DDE, and Dieldrin

Serum organochlorines and breast cancer risk in Japanese women: a case–control study

“…Our lack of association with DDE is consistent with the null results of a nested case-control study of associations between serum DDE and PCBs and breast cancer risk in Asian women by Krieger et al [15] (50 pairs), whereas our statistically significant inverse association for PCBs is not consistent with the null result for PCBs in most previous studies. Krieger et al [15] also showed an insignificant positive association between serum DDE and breast cancer in white and black women, which is inconsistent with the majority of previous studies [6,23]. The interethnic [15] has not been confirmed.…”

“…Results have been mainly null, with several inconsistent exceptions [6,10]. Some of these agents persist in the environment and are bio-accumulative.…”

“…Because established risk factors for breast cancer account for only about half of its incidence [6][7][8]; however, epidemiological studies have also examined certain organochlorine pesticides, such as dichlorodiphenyltrichloroethane (DDT) and polychlorinated biphenyls (PCBs), which have shown estrogenicity or anti-estrogenicity in experimental studies [9], as potential risk factors. Results have been mainly null, with several inconsistent exceptions [6,10].…”

Epidemiological data on the relationship between cancer and pesticides

“…Ces é tudes, essentiellement de type cas té moins, se sont affronté es à des difficulté s mé thodologiques particuliè res : pertinence de l'é valuation de l'exposition à partir de mé tabolites tels que le DDE, né cessité de prendre en compte les facteurs de confusion (â ge, histoire reproductive, tabagisme, alimentation,...), difficulté s du choix des té moins, rô le de l'amaigrissement lié au cancer dans la remise en circulation des pesticides lipophiles. Les ré sultats sont trè s variables en fonction des é tudes et ont é té analysé s dans deux revues ré centes [10,42]. Bien qu'une cohorte pros-O N C O L O G I E pective danoise ait montré un doublement du risque de cancers du sein chez les femmes pré sentant, à l'inclusion, un niveau sé rique de dieldrin é levé [25], la globalité des é tudes é pidé miologiques actuelles ne permettent pas de conclure à une é lé vation de risque.…”

Evaluation of Dispersive Liquid-Liquid Microextraction Coupled with Gas Chromatography-Microelectron Capture Detection (GC-µECD) for the Determination of Organochlorine Pesticides in Water Samples

“…1,2 A number of previous studies have pointed out that OCPs may affect the normal functions of the endocrine system to induce such toxic side effects as human breast or liver cancers, testicular tumors and even lower sperm counts in humans. [3][4][5][6] Studies involving the determination of OCPs in environmental matrices often deal with samples with low analyte concentrations containing a high number of interferential contaminants, and thus the development of inexpensive, simple and efficient sample pretreatment and analytical techniques for the detection of trace quantities of these substances in water samples is imperative not only for assessing their potential hazard risk, but also as an incentive to improve water quality.…”