Pesticides and pancreatic adenocarcinoma: A transversal epidemiological, environmental and mechanistic narrative review

Brügel, Mathias; Carlier, Claude; Reyes-Castellanos, Gabriela; Callon, Sidonie; Carrier, Alice; Bouché, Olivier

doi:10.1016/j.dld.2022.08.023

Cited by 7 publications

(2 citation statements)

References 74 publications

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“…Chemical pesticide usage is a typical strategy utilized for controlling root rot in A. chinensis. Chemical pesticides are effective for the control of pathogenic fungi; however, they also cause serious harm to ecosystems, non-target organisms, and human health [43]. The long-term use of chemical pesticides can also induce the resistance of pathogenic fungi, thus, reducing their effectiveness [44].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Potential Mechanism of Essential Oils of Three Labiatae Plants against the Pathogenic Fungi of Root Rot Disease in Atractylodes chinensis

Xie,

Si,

Zhang

et al. 2023

Horticulturae

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Atractylodes chinensis has a high medicinal value and is widely cultivated. However, root rot disease seriously affects the yield and quality of A. chinensis. To develop green and safe pesticides, the inhibitory effect of essential oils (EOs) of three Labiatae plants on the pathogenic fungi that causes root rot disease in Atractylodes chinensis was investigated. The results showed that the Origanum vulgare EO and Thymus mongolicus EO exhibited strong inhibitory effects on Fusarium oxysporum, Fusarium solani, and Fusarium redolens, with 100% inhibition rate. The low MIC values of EOs and their main components against the three pathogenic fungi indicated that all of them showed strong fungicidal effects. The MIC values of O. vulgare EO against F. oxysporum, F. solani, and F. redolens were 2.60 mg/mL, 3.13 mg/mL, and 1.56 mg/mL, respectively. Analyses using scanning electron microscopy (SEM) and transmission electron microscopy (TEM) showed that the O. vulgare EO severely damaged the cell wall and cell membrane of mycelial cells. The O. vulgare EO increased cell permeability, leading to a large leakage of cell contents (DNA and proteins). In addition, O. vulgare EO inhibited F. oxysporum by inducing ROS production and reducing the amount of intracellular GSH, leading to a large accumulation of ROS. This study showed that plant EOs have excellent fungicidal activity and can be used as novel natural and environmentally friendly pesticides for the control of root rot in A. chinensis.

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Section: Discussionmentioning

confidence: 99%

Efficacy and Potential Mechanism of Essential Oils of Three Labiatae Plants against the Pathogenic Fungi of Root Rot Disease in Atractylodes chinensis

Xie,

Si,

Zhang

et al. 2023

Horticulturae

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“…Limited and delayed diagnostic strategies increase the difficulty of diagnosis, thus severely impeding various therapeutic options. Although increasing evidence suggests that pancreatic cancer is linked to several variables, such as smoking, alcohol consumption, coffee intake, a high-fat and protein diet, and genetic background (3)(4)(5), the causes of pancreatic cancer remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Systematic analysis of expression profiles and prognostic significance of the FGF gene family in pancreatic adenocarcinoma

et al. 2022

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Pancreatic adenocarcinoma (PAAD) is a malignant tumor with one of the highest associated mortality rates worldwide, and a 5-year survival rate of <5%. Fibroblast growth factors (FGFs) serve important roles in numerous cellular functions, and dysregulation of FGFs contributes to various cancer types. However, there are few reports on the function of FGFs in PAAD. The Assistant for Clinical Bioinformatics database, Gene Expression Profiling Interactive Analysis, Kaplan-Meier plotter and Tumor Immune Estimation Resource were utilized to perform the protein-protein interaction network, functional enrichment, univariate Cox regression, least absolute shrinkage and selection operator (LASSO) Cox, differential expression, prognostic value and immune cell infiltration analyses of FGFs in patients with PAAD. Immunohistochemistry (IHC) was used to verify the predictive value of the model. A total of 22 FGF genes were identified. Based on the results of LASSO Cox regression analysis, a total of six genes, including FGF2, FGF8, FGF9, FGF13, FGF17 and FGF22, were selected for the establishment of the prognostic gene signature. High transcriptional levels of FGF17 and FGF22 were significantly associated with long overall survival. The expression of FGFs was associated with the infiltration of various immune cells. According to univariate and multivariate analyses, FGF2 and FGF8 may be useful independent prognostic biomarkers for the prognosis of patients with PAAD. IHC demonstrated that FGF2 and FGF8 were more highly expressed in PAAD tissues compared with that in normal tissues. The present findings offer a novel understanding for the selection of FGF prognostic biomarkers in PAAD.

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Association between pancreatic adenocarcinoma risk and concentration of organochlorine pesticides in adipose tissue and urine: A targeted‐screening analysis case‐control study (PESTIPAC)

Brugel,

Callon,

Carlier

et al. 2024

UEG Journal

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BackgroundKnowledge about environmental pancreatic adenocarcinoma (PA) risk factors, including pesticide exposure, remains limited. Organochlorine (OC) accumulates in adipose tissue and can help reflect long‐term exposure.Patients and MethodsAge and body mass index (BMI) of patients with PA were matched with those undergoing a surgery for a benign disease on age and BMI (1:1). Targeted analyses screened 345 pesticides and metabolites, including 29 OC, in adipose tissue and urine samples. The primary aim was to investigate the association between organochlorine concentrations in visceral fat or urine, and PA. Adjusted conditional logistic regressions were carried out accounting for multiple testing.ResultsTrans‐nonachlor (odds ratio [OR] = 1.325, 95% confidence interval [CI] [1.108–1.586]), cis‐nonachlor (OR = 15.433, 95% CI [2.733–87.136]), Mirex (OR = 2.853, 95% CI [1.213–6.713]) and 4,4 DDE (OR = 1.019, 95% CI [1.005–1.034]) in fat and a greater number of positive samples (OR = 1.758 95% CI [1.11–2.997]) were significantly associated with higher odds of PA. In contrast, as awaited, urine samples did not yield any statistically significant associations for all tested pesticides.ConclusionSome OCs were associated with higher odds of PA. The underlying mechanisms of pancreatic aggression need to be investigated to refine these findings.Trial RegistrationClinicaltrials.gov NCT04429490.

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Pesticides and pancreatic adenocarcinoma: A transversal epidemiological, environmental and mechanistic narrative review

Cited by 7 publications

References 74 publications

Efficacy and Potential Mechanism of Essential Oils of Three Labiatae Plants against the Pathogenic Fungi of Root Rot Disease in Atractylodes chinensis

Efficacy and Potential Mechanism of Essential Oils of Three Labiatae Plants against the Pathogenic Fungi of Root Rot Disease in Atractylodes chinensis

Systematic analysis of expression profiles and prognostic significance of the FGF gene family in pancreatic adenocarcinoma

Association between pancreatic adenocarcinoma risk and concentration of organochlorine pesticides in adipose tissue and urine: A targeted‐screening analysis case‐control study (PESTIPAC)

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