Pesticides at brain borders: Impact on the blood-brain barrier, neuroinflammation, and neurological risk trajectories

Cresto, Noémie; Forner-Piquer, Isabel; Baig, Asma; Chatterjee, Mousumi; Perroy, Julie; Goracci, Jacopo; Marchi, Nicola

doi:10.1016/j.chemosphere.2023.138251

Cited by 28 publications

(6 citation statements)

References 298 publications

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“…Based on clinical staging, a comprehensive treatment plan with surgery as the main treatment, supplemented by radiotherapy, chemotherapy and/or targeted therapy, is adopted, and classic thoracic surgical intervention is the preferred treatment method ( 5 ). It has been reported that after 2–3 weeks of treatment with pemetrexed, carboplatin and monoclonal antibody against pabolizumab, as well as pemetrexed, carboplatin and chemotherapy, the condition remained stable ( 5 , 36 ).…”

Section: Discussionmentioning

confidence: 99%

Lymph node and bone metastasis of pulmonary intestinal adenocarcinoma: A case report

Liu,

Feng,

Wei

et al. 2023

Oncol Lett

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Pulmonary enteric adenocarcinoma (PEAC) is a rare pathological type of lung adenocarcinoma, accounting for ~0.6% of primary lung adenocarcinoma, which has similar morphological and immunohistochemical characteristics to colorectal adenocarcinoma. Making a certain differential diagnosis of PEAC based on morphological and immunohistochemical results is difficult. It is known that PEAC may metastasize to the pancreas, skin, soleus muscle and intestine, but no bone metastasis has been reported. At our department, a rare case of PEAC with bone and lymph node metastasis was previously diagnosed. The present case study reports on a 58-year-old male patient encountered at our hospital with pain in the lumbar, back and right iliac with no obvious cause. Chest CT indicated a space-occupying lesion in the left upper lung lobe, enlarged lymph nodes in the mediastinum and left lung, and partial vertebral bone destruction. Enhanced CT results indicated multiple foci of active bone metabolism in the body, while rectal colonoscopy showed no obvious abnormalities. Histopathological and immunohistochemical results after right iliac bone puncture suggested stage IV PEAC with secondary malignancies in bones, mediastinal lymph node, hilar lymph node and left supraclavicular lymph node.

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Section: Discussionmentioning

confidence: 99%

Lymph node and bone metastasis of pulmonary intestinal adenocarcinoma: A case report

Liu,

Feng,

Wei

et al. 2023

Oncol Lett

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“…Given the indispensable role of pesticides in agricultural development, humans are exposed to these chemicals through various means such as occupational activities, agricultural practices, domestic use, and air, water, soil, and food contamination. Similar to heavy metals, this exposure leads to disruption of the BBB and activation of astrocytes, based on numerous studies conducted in vivo and in vitro [68][69][70][71][72][73][74]. Furthermore, research has indicated that Parkinson's disease protein 7 (PARK7/DJ-1), found in astrocytes, plays a crucial role in regulating the neurotoxic consequences caused by the pesticide rotenone [75][76][77].…”

Section: Link Between Reactive Astrocytes and Environmental Elementsmentioning

confidence: 99%

The Diverse Roles of Reactive Astrocytes in the Pathogenesis of Amyotrophic Lateral Sclerosis

Yang,

Liu,

Zhang

2024

Brain Sciences

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Astrocytes displaying reactive phenotypes are characterized by their ability to remodel morphologically, molecularly, and functionally in response to pathological stimuli. This process results in the loss of their typical astrocyte functions and the acquisition of neurotoxic or neuroprotective roles. A growing body of research indicates that these reactive astrocytes play a pivotal role in the pathogenesis of amyotrophic lateral sclerosis (ALS), involving calcium homeostasis imbalance, mitochondrial dysfunction, abnormal lipid and lactate metabolism, glutamate excitotoxicity, etc. This review summarizes the characteristics of reactive astrocytes, their role in the pathogenesis of ALS, and recent advancements in astrocyte-targeting strategies.

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“…Short and long-term exposure to toxins has shown bioaccumulation in different tissues, including the gut, lungs, and central nervous system [10]. In consequence, these toxins can interfere with cellular processes, inducing neurotoxicity and altering the host immune response [11]. Indeed, experimental studies have demonstrated that exposure to a range of environmental toxins can disrupt host homeostasis by impairing the cellular response of the immune system, particularly at barrier sites such as the gut and lungs [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Exposure to Environmental Toxins: Potential Implications for Stroke Risk via the Gut– and Lung–Brain Axis

Ruggles,

Benakis

2024

Cells

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Recent evidence suggests that exposure to environmental toxins, both short-term and long-term, can increase the risk of developing neurological disorders, including neurodegenerative diseases (i.e., Alzheimer’s disease and other dementias) and acute brain injury (i.e., stroke). For stroke, the latest systematic analysis revealed that exposure to ambient particulate matter is the second most frequent stroke risk after high blood pressure. However, preclinical and clinical stroke investigations on the deleterious consequences of environmental pollutants are scarce. This review examines recent evidence of how environmental toxins, absorbed along the digestive tract or inhaled through the lungs, affect the host cellular response. We particularly address the consequences of environmental toxins on the immune response and the microbiome at the gut and lung barrier sites. Additionally, this review highlights findings showing the potential contribution of environmental toxins to an increased risk of stroke. A better understanding of the biological mechanisms underlying exposure to environmental toxins has the potential to mitigate stroke risk and other neurological disorders.

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Pesticides at brain borders: Impact on the blood-brain barrier, neuroinflammation, and neurological risk trajectories

Cited by 28 publications

References 298 publications

Lymph node and bone metastasis of pulmonary intestinal adenocarcinoma: A case report

Lymph node and bone metastasis of pulmonary intestinal adenocarcinoma: A case report

The Diverse Roles of Reactive Astrocytes in the Pathogenesis of Amyotrophic Lateral Sclerosis

Exposure to Environmental Toxins: Potential Implications for Stroke Risk via the Gut– and Lung–Brain Axis

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