Pesticides (Hexachlorocyclohexane, Aldrin, and Malathion) Residues in Home‐Grown Eggs: Prevalence, Distribution, and Effect of Storage and Heat Treatments

Alaboudi, Akram R.; Osaili, Tareq M.; Alrwashdeh, Arwa

doi:10.1111/1750-3841.14918

Cited by 13 publications

(4 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general, both research toxicity studies and pesticide registration protocols focus on assessing the effects of isolated active substances, while the effects of combined compounds are only assessed when those are part of the same formulation. However, the simultaneous application of two or more pesticides in the same agricultural area is a common event during the same cropping season. , Hence, a complex cocktail of agrochemicals, which are not coformulated as single products, can be simultaneously detected in food and water samples. − …”

Section: Discussionmentioning

confidence: 99%

Mechanisms Mediating the Combined Toxicity of Paraquat and Maneb in SH-SY5Y Neuroblastoma Cells

da Silva,

da Costa,

Naime

et al. 2024

Chem. Res. Toxicol.

View full text Add to dashboard Cite

Epidemiological and experimental studies have demonstrated that combined exposure to the pesticides paraquat (PQ) and maneb (MB) increases the risk of developing Parkinson's disease. However, the mechanisms mediating the toxicity induced by combined exposure to these pesticides are not well understood. The aim of this study was to investigate the mechanism(s) of neurotoxicity induced by exposure to the pesticides PQ and MB isolated or in association (PQ + MB) in SH-SY5Y neuroblastoma cells. PQ + MB exposure for 24 and 48 h decreased cell viability and disrupted cell membrane integrity. In addition, PQ + MB exposure for 12 h decreased the mitochondrial membrane potential. PQ alone increased reactive oxygen species (ROS) and superoxide anion generation and decreased the activity of mitochondrial complexes I and II at 12 h of exposure. MB alone increased ROS generation and depleted intracellular glutathione (GSH) within 6 h of exposure. In contrast, MB exposure for 12 h increased the GSH levels, the glutamate cysteine ligase (GCL, the rate-limiting enzyme in the GSH synthesis pathway) activity, and increased nuclear Nrf2 staining. Pretreatment with buthionine sulfoximine (BSO, a GCL inhibitor) abolished the MB-mediated GSH increase, indicating that MB increases GSH synthesis by upregulating GCL, probably by the activation of the Nrf2/ARE pathway. BSO pretreatment, which did not modify cell viability per se, rendered cells more sensitive to MB-induced toxicity. In contrast, treatment with the antioxidant N-acetylcysteine protected cells from MB-induced toxicity. These findings show that the combined exposure of SH-SY5Y cells to PQ and MB induced a cytotoxic effect higher than that observed when cells were subjected to individual exposures. Such a higher effect seems to be related to additive toxic events resulting from PQ and MB exposures. Thus, our study contributes to a better understanding of the toxicity of PQ and MB in combined exposures.

show abstract

Section: Discussionmentioning

confidence: 99%

Mechanisms Mediating the Combined Toxicity of Paraquat and Maneb in SH-SY5Y Neuroblastoma Cells

da Silva,

da Costa,

Naime

et al. 2024

Chem. Res. Toxicol.

View full text Add to dashboard Cite

show abstract

“…A study was conducted on the home produced eggs in Jordan revealed that are highly contaminated with pesticide residues particularly Malathion (44%) and Aldrin (33%), at an unacceptable high limits and form potential harmful to the consumer (Alaboudi et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Veterinarian Role in One Health Approach at Antimicrobial Resistance Perspectives, Jordan

Bazzi¹,

Alaboudi²,

Rácz³

2021

Lélektan és hadviselés

View full text Add to dashboard Cite

Antimicrobials are widely used in human and veterinary medicine around the world for disease control and prevention. Due to inefficient or prolonged antimicrobial treatment, the microbes may become resistant, which will pose public health and socioeconomic threat, as it is transmitted to humans through the environment and food products. To address the potential health of AMR, WHO collaborated with OIE and FOA to implement the Global Action Plan and urged the member countries to develop a national plan, to combat AMR in all aspects. The Ministry of Health in Jordan has conducted the national plan for combatting AMR (2018-2022), in which the MOA and JVA play a critical role as stakeholders for intervening the plan strategies in animal health sector. This study aims to evaluate the role of the Jordanian veterinarian’s knowledge, attitudes, and practices in tackling AMR, as well as it will include the registered veterinary pharmaceutical products between 2017-2020. A web based cross-sectional KAP survey link was distributed to the veterinarian who is registered in the JAV. Reports of the registered pharmaceutical products were obtained from JAV and then categorized into imported and produced drugs. The results were analysed descriptively and showed that the average knowledge of the participant who had agreed with the statement that refers to the AMR definition was 84%. The majority (95.65%) considered AMR as a challenge for the veterinary sector in Jordan and should be prioritized beside other zoonotic diseases. A 68.70% of the participants believe that the misuse and overuse of antimicrobial by quacks, fraudulent and unauthorized practitioners are the main contributor to the AMR challenge, and the most common practices among them were recommending the customers (farmers, owner, etc..) to practice good animal husbandries (80.00%).To conclude, implementing antimicrobial resistance continual educational program is essential to improve the veterinarian knowledge in all aspects of AMR; to enhance their advisory skills. Also obligating legislations that ensure the veterinarian to prescribe the correct antimicrobials and improving the surveillance system to monitor the antimicrobial consumption in the veterinary field.

show abstract

“…The identification and concentrations of the questioned pesticides (endosulfan, heptachlor, malathion, chlorpyrifos, bifenthrin, deltamethrin, and fenoxycarb) were analyzed using liquid chromatography with tandem mass spectrometry (LC-MS/MS) as per United States Department of Agriculture Food Safety and Inspection Service, Office of Public Health Science (2018) and as previously described (Alaboudi et al, 2019).…”

Section: Pesticides Quantitationmentioning

confidence: 99%

Effect of Cooking and Freezing on Levels of pesticides residues in Local Fresh Fish

Alaboudi

Almashhadany²,

JARRAH

2022

BUASVMCN-ASB

View full text Add to dashboard Cite

Pesticides are an important part of pests controlling strategies. Misuse of such chemicals has been linked to pollution of various environments and toxicities that lead to various health conditions and diseases. Importance of healthy and non-contaminated fish for human diet is essentially required. Samples of 14 local fresh fish (tilapia, grey mullet, and cat fish) were analyzed for seven pesticides (endosulfan, heptachlor, malathion, chlorpyrifos, bifenthrin, deltamethrin, and fenoxycarb) using liquid chromatography with tandem mass spectrometry (LC-MS/MS). Heat processing applied for positive samples by two different cooking method (roasting at 79 °C for 10 min and frying at 210 °C for 40 min) have influenced the levels of studied pesticides and significantly reduced their levels by 53-95%. Freezing preservation of contaminated fish at -70 °C for one month only reduced the level of the pesticides by 6-30%, however, final reduced levels were not below recommended maximum residue limit values.

show abstract

Pesticides (Hexachlorocyclohexane, Aldrin, and Malathion) Residues in Home‐Grown Eggs: Prevalence, Distribution, and Effect of Storage and Heat Treatments

Cited by 13 publications

References 38 publications

Mechanisms Mediating the Combined Toxicity of Paraquat and Maneb in SH-SY5Y Neuroblastoma Cells

Mechanisms Mediating the Combined Toxicity of Paraquat and Maneb in SH-SY5Y Neuroblastoma Cells

Evaluating the Veterinarian Role in One Health Approach at Antimicrobial Resistance Perspectives, Jordan

Effect of Cooking and Freezing on Levels of pesticides residues in Local Fresh Fish

Contact Info

Product

Resources

About