Pesticides labelled with 14C.: IV. Synthesis of diuron and linuron in various positions

Abstract

SUMMARYDiuron and Linuron, two herbicides, with very similar structures were labelled in their aromatic ring with I4C. The yields of the synthesis (starting from BaI4C03) was 8.5% and 4.8%, respectively. Linuron was also labelled with 14C in its urea group with 3 3 % yield.

Preparation of Carbon‐14‐Labeled Compounds via Multi‐Carbon Building Blocks of the [ 14 C]Carbon Dioxide Tree

“…For example, benzyl bromo½2-14 Cacetate reacts with silver nitrate to give benzyl nitrooxy½2-14 Cacetate (217), which upon treatment with tetrabutylammonium fluoride provided benzyl ½2-14 Cglyoxylate (218) in 60% overall radiochemical yield. For example, benzyl bromo½2-14 Cacetate reacts with silver nitrate to give benzyl nitrooxy½2-14 Cacetate (217), which upon treatment with tetrabutylammonium fluoride provided benzyl ½2-14 Cglyoxylate (218) in 60% overall radiochemical yield.…”