Pesticides Mechanisms of Action in Living Organisms

Coman, Gheorghe; Farcas, Alina; Matei, Andreea Valceanu; Florian, Cristina

doi:10.1007/978-94-007-6461-3_16

Cited by 4 publications

(1 citation statement)

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“…Historically, the consumption of Calabar beans ( Physostigma venenosum ) with substantial content of physostigmine and related carbamate alkaloids in trial by ordeals led to considerable mortality even in the 19th century . Currently, apart from wars and terrorist attacks, accidental intoxication with subsequent death is still possible (e.g., by agricultural insecticides) . At low doses, the muscarinic effects on the heart predominate and these include, bradycardia and other dysrhythmias.…”

Section: Drugs With the Major Effects On The Heartmentioning

confidence: 99%

Comprehensive review of cardiovascular toxicity of drugs and related agents

Mladěnka

Applová

Patočka

et al. 2018

Medicinal Research Reviews

216

120

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Cardiovascular diseases are a leading cause of morbidity and mortality in most developed countries of the world. Pharmaceuticals, illicit drugs, and toxins can significantly contribute to the overall cardiovascular burden and thus deserve attention. The present article is a systematic overview of drugs that may induce distinct cardiovascular toxicity. The compounds are classified into agents that have significant effects on the heart, blood vessels, or both. The mechanism(s) of toxic action are discussed and treatment modalities are briefly mentioned in relevant cases. Due to the large number of clinically relevant compounds discussed, this article could be of interest to a broad audience including pharmacologists and toxicologists, pharmacists, physicians, and medicinal chemists. Particular emphasis is given to clinically relevant topics including the cardiovascular toxicity of illicit sympathomimetic drugs (e.g., cocaine, amphetamines, cathinones), drugs that prolong the QT interval, antidysrhythmic drugs, digoxin and other cardioactive steroids, beta‐blockers, calcium channel blockers, female hormones, nonsteroidal anti‐inflammatory, and anticancer compounds encompassing anthracyclines and novel targeted therapy interfering with the HER2 or the vascular endothelial growth factor pathway.

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Section: Drugs With the Major Effects On The Heartmentioning

confidence: 99%