“…Moreover, MRI BAE was based mostly on hippocampal volume, a measure known to be associated with risk for dementia, and MRI BAG showed a moderate potential to predict MCI-to-AD progression. The increased association with CSF, compared with PET amyloid information, is likely due to the comparably early abnormality of CSF amyloid versus PET amyloid (20), as fluid amyloid biomarker signal disrupted amyloid metabolism whereas amyloid PET reveals resultant plaque aggregation. Therefore, MRI BAG closely reflects cognitive performance and relatively early pathologic markers of AD in SCD and MCI.…”