2019
DOI: 10.1101/673467
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PET and CSF amyloid-β status are differently predicted by patient features: Information from discordant cases

Abstract: Background:Amyloid-β PET and CSF Aβ42 yield discordant results in 10-20% of patients, possibly providing unique information. Although the predictive power of demographic, clinical, genetic and imaging features for amyloid-positivity has previously been investigated, it is unknown whether these features differentially predict amyloid-β status based on PET or CSF, or whether this differs by disease stage. Methods:We included 768 patients (subjective cognitive decline (SCD, n=194), mild cognitive impairment (MCI,… Show more

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“…Moreover, MRI BAE was based mostly on hippocampal volume, a measure known to be associated with risk for dementia, and MRI BAG showed a moderate potential to predict MCI-to-AD progression. The increased association with CSF, compared with PET amyloid information, is likely due to the comparably early abnormality of CSF amyloid versus PET amyloid (20), as fluid amyloid biomarker signal disrupted amyloid metabolism whereas amyloid PET reveals resultant plaque aggregation. Therefore, MRI BAG closely reflects cognitive performance and relatively early pathologic markers of AD in SCD and MCI.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, MRI BAE was based mostly on hippocampal volume, a measure known to be associated with risk for dementia, and MRI BAG showed a moderate potential to predict MCI-to-AD progression. The increased association with CSF, compared with PET amyloid information, is likely due to the comparably early abnormality of CSF amyloid versus PET amyloid (20), as fluid amyloid biomarker signal disrupted amyloid metabolism whereas amyloid PET reveals resultant plaque aggregation. Therefore, MRI BAG closely reflects cognitive performance and relatively early pathologic markers of AD in SCD and MCI.…”
Section: Discussionmentioning
confidence: 99%