PET and SPECT Imaging of Steroid Hormone Receptors in the Brain

Moraga-Amaro, Rodrigo; Doorduin, Janine; Dierckx, Rudi; Vries, Erik F. J. de

doi:10.1007/978-3-030-53176-8_14

Cited by 2 publications

(2 citation statements)

References 185 publications

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“…Estrogen receptor density in the living human brain may be assessed by non-invasive imaging techniques, such as positron emission tomography (PET). Several PET tracers have been developed for the purpose of ER imaging [ 4 ]. Among these, 16α-[ 18 F]-fluoro-17β-estradiol ([ 18 F]FES) is the best-characterized tracer with high affinity and selectivity for ER.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic Analysis of [18F]FES PET in the Human Brain and Pituitary Gland

Ghazanfari,

Doorduin,

van der Weijden

et al. 2024

Mol Imaging Biol

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Purpose Estrogen receptors (ER) are implicated in psychiatric disorders. We assessed if ER availability in the human brain could be quantified using 16α-[18F]-fluoro-17β-estradiol ([18F]FES) positron emission tomography (PET). Procedures Seven post‑menopausal women underwent a dynamic [18F]FES PET scan with arterial blood sampling. A T1-weighted MRI was acquired for anatomical information. After one week, four subjects received a selective ER degrader (SERD), four hours before the PET scan. Pharmacokinetic analysis was performed using a metabolite-corrected plasma curve as the input function. The optimal kinetic model was selected based on the Akaike information criterion and standard error of estimated parameters. Accuracy of Logan graphical analysis and standardized uptake value (SUV) was determined via correlational analyses. Results The reversible two-tissue compartment model (2T4k) model with fixed K1/k2 was preferred. The total volume of distribution (VT) could be more reliably estimated than the binding potential (BPND). A high correlation of VT with Logan graphical analysis was observed, but only a moderate correlation with SUV. SERD administration resulted in a reduced VT in the pituitary gland, but not in other regions. Conclusions The optimal quantification method for [18F]FES was the 2T4k with fixed K1/k2 or Logan graphical analysis, but specific binding was only observed in the pituitary gland.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetic Analysis of [18F]FES PET in the Human Brain and Pituitary Gland

Ghazanfari,

Doorduin,

van der Weijden

et al. 2024

Mol Imaging Biol

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show abstract

“…Estrogen receptor density in the living human brain may be assessed by non-invasive imaging techniques, such as positron emission tomography (PET). Several PET tracers have been developed for the purpose of ER imaging (4). Among these, 16α-18 F-uoro-17β-estradiol ([ 18 F]-FES) is the best-characterized tracer with high a nity and selectivity for ER.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic Analysis of [18F]-FES PET in the Human Brain and Pituitary Gland

Ghanzafari,

Doorduin,

Weijden

et al. 2023

Preprint

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Purpose Estrogen receptors (ER) are implicated in psychiatric disorders. We assessed if ER availability in the human brain could be quantified using 16α-[18F]-fluoro-17β-estradiol ([18F]-FES) positron emission tomography (PET). Procedures Seven post‑menopausal women underwent a dynamic [18F]-FES PET scan with arterial blood sampling. A T1-weighted MRI was acquired for anatomical information. After one week, four subjects received a selective ER degrader (SERD), four hours before the PET scan. Pharmacokinetic analysis was performed using a metabolite-corrected plasma curve as the input function. The optimal kinetic model was selected based on the Akaike information criterion and standard error of estimated parameters. Accuracy of Logan graphical analysis and standardized uptake value (SUV) was determined via correlational analyses. Results The reversible two-tissue compartment model (2T4k) model with fixed K1/k2 was preferred. The total volume of distribution (VT) could be more reliably estimated than the binding potential (BPND). A high correlation of VT with Logan graphical analysis was observed, but only a moderate correlation with SUV. SERD administration resulted in a reduced VT in the pituitary gland, but not in other regions. Conclusions The optimal quantification method for [18F]-FES was the 2T4k with fixed K1/k2 or Logan graphical analysis, but specific binding was only observed in the pituitary gland.

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PET and SPECT Imaging of Steroid Hormone Receptors in the Brain

Cited by 2 publications

References 185 publications

Pharmacokinetic Analysis of [18F]FES PET in the Human Brain and Pituitary Gland

Pharmacokinetic Analysis of [18F]FES PET in the Human Brain and Pituitary Gland

Pharmacokinetic Analysis of [18F]-FES PET in the Human Brain and Pituitary Gland

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