PET characteristics of a dedicated breast PET/CT scanner prototype

Wu, Yue; Bowen, Samuel P.; Yang, Kai; Packard, N.; Fu, Lin; Burkett, George W.; Qi, Jinyi; Boone, John M.; Cherry, Simon R.; Badawi, Ramsey D.

doi:10.1088/0031-9155/54/13/020

Cited by 48 publications

(52 citation statements)

References 40 publications

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“…The measured sensitivities (11.2%; 101.4 cps/kBq) were comparable to or more than twice those of currently available breast PET cameras (3,6,10). This was achieved by the large solid angle of the detector crystals, with a high packing fraction, and the fourth-layer DOI detector (18 mm 5 4.5 · 4).…”

Section: Discussionsupporting

confidence: 58%

“…Fully tomographic dedicated PET systems have also been introduced. This type of scanner acquires fully tomographic images by rotating 2 or more planar heads (9)(10)(11) or by completely encircling the breast with detectors (12)(13)(14). Previous simulation studies have shown that, with depth-ofinteraction (DOI) measurement capability, a rectangular tomographic scanner designed to encircle the breast outperforms dual planar designs (with or without DOI) in terms of system sensitivity and image quality (15,16).…”

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confidence: 99%

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Performance Evaluation of a New Dedicated Breast PET Scanner Using NEMA NU4-2008 Standards

et al. 2014

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The aim of this work was to evaluate the performance characteristics of a newly developed dedicated breast PET scanner, according to National Electrical Manufacturers Association (NEMA) NU 4-2008 standards. Methods: The dedicated breast PET scanner consists of 4 layers of a 32 · 32 lutetium oxyorthosilicate-based crystal array, a light guide, and a 64-channel position-sensitive photomultiplier tube. The size of a crystal element is 1.44 · 1.44 · 4.5 mm. The detector ring has a large solid angle with a 185-mm aperture and an axial coverage of 155.5 mm. The energy windows at depth of interaction for the first and second layers are 400-800 keV, and those at the third and fourth layers are 100-800 keV. A fixed timing window of 4.5 ns was used for all acquisitions. Spatial resolution, sensitivity, counting rate capabilities, and image quality were evaluated in accordance with NEMA NU 4-2008 standards. Human imaging was performed in addition to the evaluation. Results: Radial, tangential, and axial spatial resolution measured as minimal full width at half maximum approached 1.6, 1.7, and 2.0 mm, respectively, for filtered backprojection reconstruction and 0.8, 0.8, and 0.8 mm, respectively, for dynamic row-action maximum-likelihood algorithm reconstruction. The peak absolute sensitivity of the system was 11.2%. Scatter fraction at the same acquisition settings was 30.1% for the rat-sized phantom. Peak noise-equivalent counting rate and peak true rate for the ratlike phantom was 374 kcps at 25 MBq and 603 kcps at 31 MBq, respectively. In the image-quality phantom study, recovery coefficients and uniformity were 0.04-0.82 and 1.9%, respectively, for standard reconstruction mode and 0.09-0.97 and 4.5%, respectively, for enhanced-resolution mode. Human imaging provided highcontrast images with restricted background noise for standard reconstruction mode and high-resolution images for enhancedresolution mode. Conclusion: The dedicated breast PET scanner has excellent spatial resolution and high sensitivity. The performance of the dedicated breast PET scanner is considered to be reasonable enough to support its use in breast cancer imaging. Br east cancer is one of the leading causes of cancer death among women worldwide, accounting for 425,000 deaths in 187 countries in 2010 (1). A strategy for reducing breast cancer mortality is early detection for successful treatment. PET systems dedicated to the breast have been under development since 1994, when Thompson et al. reported the feasibility of the first of these systems (2). The dedicated PET systems are intended to have higher photon sensitivity and improved spatial resolution by bringing the detectors close to the breast and by using smaller detector elements than those for whole-body tomography. Most of the dedicated PET systems perform positron emission mammography with 2 planar or curved detector heads that can compress the breast mildly, providing planar and limited-angle tomography images (3-8). Fully tomographic dedicated PET systems have also been introduced. This...

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Section: Discussionsupporting

confidence: 58%

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confidence: 99%

Performance Evaluation of a New Dedicated Breast PET Scanner Using NEMA NU4-2008 Standards

et al. 2014

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“…Systems capable of limited-angle acquisition, such as the positron emission mammography Flex Solo II, also have a compromised ability for radiotracer activity quantification. 14 A high-resolution extremity PET/CT scanner adaptable to wrist and hand imaging was built, 15 and its characterization in conditions typical for patient imaging was reported. 15,16 This system fully produces tomographic images with a spatial resolution of approximately 2.5 mm for the PET component and approximately 0.3 mm for the CT component.…”

Section: Introductionmentioning

confidence: 99%

“…14 A high-resolution extremity PET/CT scanner adaptable to wrist and hand imaging was built, 15 and its characterization in conditions typical for patient imaging was reported. 15,16 This system fully produces tomographic images with a spatial resolution of approximately 2.5 mm for the PET component and approximately 0.3 mm for the CT component. We report-employing prospective imaging data in human patients with established RA and PsA-the ability of this high-resolution PET/CT system to characterize and quantify disease activity and pathology associated with the two arthritides in the wrist and hand.…”

Section: Introductionmentioning

confidence: 99%

High-resolution¹⁸F-FDG PET/CT for assessing disease activity in rheumatoid and psoriatic arthritis: findings of a prospective pilot study

Chaudhari¹,

Ferrero²,

Godinez³

et al. 2016

BJR

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Objective: Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) commonly affect the small joints of the wrist and hand. We evaluated the performance of a new, highresolution extremity positron emission tomography (PET)/CT scanner for characterizing and quantifying pathologies associated with the two arthritides in the wrist and hand joints. Methods: Patients with RA or PsA underwent fluorine-18 fludeoxyglucose ( 18 F-FDG) PET/CT wrist and hand imaging, respectively, on the high-resolution scanner. Calibrated CT images and co-registered PET images were reconstructed. PET/CT was derived for the radiocarpal and pisiform-triquetral compartments, joints with erosive changes, sites of synovitis or tenosynovitis and the nail bed and were correlated with clinical and MRI findings.

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“…To find k similar neighbors for each feature vector, a knn search was carried out using the knnsearch function in MATLAB according to Euclidean distance between the feature vectors, not the physical distance among the finite element nodes in the Cartesian coordinates. In this study, three different values of k (16,32,64), the number of nearest neighbors, were studied. Only those elements corresponding to the k-nearest neighbors were kept in the kernel matrix and the rest of them were set to be 0.…”

Section: Kernel-based Anatomically-aided Reconstruction Algorithmmentioning

confidence: 99%

Kernel-based anatomically-aided diffuse optical tomography reconstruction

Baikejiang¹,

Zhang²,

Zhu³

et al. 2017

Biomed. Phys. Eng. Express

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Image reconstruction in diffuse optical tomography (DOT) is a challenging task because its inverse problem is nonlinear, ill-posed and ill-conditioned. Anatomical guidance from imaging modalities with high spatial resolution can substantially improve the quality of reconstructed DOT images. In this paper, inspired by the kernel methods in machine learning, we proposed a kernel method to introduce anatomical guidance into the DOT image reconstruction. In this kernel method, the optical absorption coefficient at each finite element node is represented as a function of a set of features obtained from anatomical images such as computed tomography (CT) images. Compared with Laplacian approaches that include structural priors, the proposed method does not require image segmentation. The proposed kernel method is validated with numerical simulations of 3D DOT reconstruction using synthetic CT data. 5% Gaussian noise was added to both the numerical DOT measurements and the simulated CT image. The proposed method was also validated by an agar phantom experiment with the anatomical guidance from a cone beam CT scan. The effects of voxel size and number of nearest neighborhood size in the kernel method on the reconstructed DOT images were studied. The results indicate that the spatial resolution and the accuracy of the reconstructed DOT images have been improved substantially after applying the anatomical guidance with the proposed kernel method comparing to the case without guidance. Furthermore, we demonstrated that the kernel method was able to utilize clinical breast CT images as anatomical guidance without segmentation. In addition, we found that the proposed kernel method was robust to the false positive guidance in the anatomical image.

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PET characteristics of a dedicated breast PET/CT scanner prototype

Cited by 48 publications

References 40 publications

Performance Evaluation of a New Dedicated Breast PET Scanner Using NEMA NU4-2008 Standards

Performance Evaluation of a New Dedicated Breast PET Scanner Using NEMA NU4-2008 Standards

High-resolution¹⁸F-FDG PET/CT for assessing disease activity in rheumatoid and psoriatic arthritis: findings of a prospective pilot study

Kernel-based anatomically-aided diffuse optical tomography reconstruction

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PET characteristics of a dedicated breast PET/CT scanner prototype

Cited by 48 publications

References 40 publications

Performance Evaluation of a New Dedicated Breast PET Scanner Using NEMA NU4-2008 Standards

Performance Evaluation of a New Dedicated Breast PET Scanner Using NEMA NU4-2008 Standards

High-resolution18F-FDG PET/CT for assessing disease activity in rheumatoid and psoriatic arthritis: findings of a prospective pilot study

Kernel-based anatomically-aided diffuse optical tomography reconstruction

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High-resolution¹⁸F-FDG PET/CT for assessing disease activity in rheumatoid and psoriatic arthritis: findings of a prospective pilot study