PET/CT demonstrates increased myocardial FDG uptake following irradiation therapy

Zöphel, Klaus; Hölzel, C.; Dawel, M.; Hölscher, Tobias; Evers, C.; Kotzerke, J.

doi:10.1007/s00259-007-0469-3

Cited by 26 publications

(13 citation statements)

References 4 publications

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“…In addition, the ratio of the irradiated field to the non-irradiated field SUV was significantly higher after irradiation than before irradiation. These findings are consistent with those of the previous clinical reports ( 9 10 11 ). However, this study was prospective rather than retrospective.…”

Section: Discussionsupporting

confidence: 94%

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Detection of Myocardial Metabolic Abnormalities by 18F-FDG PET/CT and Corresponding Pathological Changes in Beagles with Local Heart Irradiation

Yan

Song

et al. 2015

Korean J Radiol

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ObjectiveTo determine the efficacy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in the detection of radiation-induced myocardial damage in beagles by comparing two pre-scan preparation protocols as well as to determine the correlation between abnormal myocardial FDG uptake and pathological findings.Materials and MethodsThe anterior myocardium of 12 beagles received radiotherapy locally with a single X-ray dose of 20 Gy. 18F-FDG cardiac PET/CT was performed at baseline and 3 months after radiation. Twelve beagles underwent two protocols before PET/CT: 12 hours of fasting (12H-F), 12H-F followed by a high-fat diet (F-HFD). Regions of interest were drawn on the irradiation and the non-irradiation fields to obtain their maximal standardized uptake values (SUVmax). Then the ratio of the SUV of the irradiation to the non-irradiation fields (INR) was computed. Histopathological changes were identified by light and electron microscopy.ResultsUsing the 12H-F protocol, the average INRs were 1.18 ± 0.10 and 1.41 ± 0.18 before and after irradiation, respectively (p = 0.021). Using the F-HFD protocol, the average INRs were 0.99 ± 0.15 and 2.54 ± 0.43, respectively (p < 0.001). High FDG uptake in irradiation field was detected in 33.3% (4/12) of 12H-F protocol and 83.3% (10/12) of F-HFD protocol in visual analysis, respectively (p = 0.031). The pathology of the irradiated myocardium showed obvious perivascular fibrosis and changes in mitochondrial vacuoles.ConclusionHigh FDG uptake in an irradiated field may be related with radiation-induced myocardial damage resulting from microvascular damage and mitochondrial injury. An F-HFD preparation protocol used before obtaining PET/CT can improve the sensitivity of the detection of cardiotoxicity associated with radiotherapy.

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Section: Discussionsupporting

confidence: 94%

“…It is an important noninvasive technique for follow-up after chemoradiotherapy for thoracic tumors. Several studies have found that focal increased 18F-FDG uptake in the irradiation field is sometimes seen in patients with thoracic tumors after RT ( 9 10 11 ). We suspected that abnormal 18F-FDG uptake might be related to RIHD.…”

Section: Introductionmentioning

confidence: 99%

Detection of Myocardial Metabolic Abnormalities by 18F-FDG PET/CT and Corresponding Pathological Changes in Beagles with Local Heart Irradiation

Yan

Song

et al. 2015

Korean J Radiol

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“…PET has an advantage of possibly shorter exam times than SPECT, but is similarly limited to imaging only the left ventricle (155). A recent case report noted increased FDG uptake within cardiac regions receiving ≥25 Gy ~ 4 years earlier; the patient was asymptomatic and had a normal ECG (156). …”

Section: Heart Injurymentioning

confidence: 99%

Imaging Radiation-Induced Normal Tissue Injury

et al. 2012

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Technological developments in radiation therapy and other cancer therapies have led to a progressive increase in five-year survival rates over the last few decades. Although acute effects have been largely minimized by both technical advances and medical interventions, late effects remain a concern. Indeed, the need to identify those individuals who will develop radiation-induced late effects, and to develop interventions to prevent or ameliorate these late effects is a critical area of radiobiology research. In the last two decades, preclinical studies have clearly established that late radiation injury can be prevented/ameliorated by pharmacological therapies aimed at modulating the cascade of events leading to the clinical expression of radiation-induced late effects. These insights have been accompanied by significant technological advances in imaging that are moving radiation oncology and normal tissue radiobiology from disciplines driven by anatomy and macrostructure to ones in which important quantitative functional, microstructural, and metabolic data can be noninvasively and serially determined. In the current article, we review use of positron emission tomography (PET), single photon emission tomography (SPECT), magnetic resonance (MR) imaging and MR spectroscopy to generate pathophysiological and functional data in the central nervous system, lung, and heart that offer the promise of, (1) identifying individuals who are at risk of developing radiation-induced late effects, and (2) monitoring the efficacy of interventions to prevent/ameliorate them.

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“…PET has been suggested as having improved resolution and accuracy as compared to SPECT, in addition to allowing patients shorter exam times while similar to SPECT, only having the capability of imaging the left ventricle (Chua et al 2006). A case report noted an increased FDG uptake within cardiac regions receiving C25 Gy approximately 4 years earlier (Zophel et al 2007). The patient was asymptomatic and had a normal ECG (Fig.…”

Section: Cardiac Petmentioning

confidence: 96%

Quantitative/Objective Analyses of RT-Induced Late Normal Tissue Injury Using Functional Imaging

Nam

Robbins

Marks

2013

ALERT - Adverse Late Effects of Cancer Treatment

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PET/CT demonstrates increased myocardial FDG uptake following irradiation therapy

Cited by 26 publications

References 4 publications

Detection of Myocardial Metabolic Abnormalities by 18F-FDG PET/CT and Corresponding Pathological Changes in Beagles with Local Heart Irradiation

Detection of Myocardial Metabolic Abnormalities by 18F-FDG PET/CT and Corresponding Pathological Changes in Beagles with Local Heart Irradiation

Imaging Radiation-Induced Normal Tissue Injury

Quantitative/Objective Analyses of RT-Induced Late Normal Tissue Injury Using Functional Imaging

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