PET/CT in Benign and Malignant Musculoskeletal Tumors and Tumor-Like Conditions

Choi, Yun Young; Kim, Ji Young; Yang, Seoung-Oh

doi:10.1055/s-0034-1371016

Cited by 38 publications

(22 citation statements)

References 36 publications

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“…Clinical symptoms frequently consist of pain and neurologic symptoms due to compression of the spinal cord following vertebral compression fracture, which can be occurred in a wide variety of benign and malignant lesions on the spine. Moreover, solitary osteolytic cervical vertebral lesion with increased FDG-uptake is non-specific, it can be observed in various pathological conditions including metastasis, solitary plasmacytoma, osteoclastoma, lymphoma, aneurysmal bone cyst, eosinophilic granuloma, tuberculosis, and so on [ 11 – 22 ].…”

Section: Discussionmentioning

confidence: 99%

Solitary vertebral metastatic glioblastoma in the absence of primary brain tumor relapse: a case report and literature review

Zheng

Zhao

et al. 2020

BMC Med Imaging

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Background: Metastatic glioblastoma presenting as a solitary osteolytic cervical vertebral mass without primary brain tumor relapse is extremely rare with only 1 reported case in the literature. Because of its rarity, it can be easily overlooked and misdiagnosed, posing a diagnostic dilemma. Case presentation: A 51-year-old man with right temporal glioblastoma was initially treated by tumor resection, radiotherapy and chemotherapy. Eighteen months after surgery, he was readmitted with complaints of neck pain for 2 weeks. Follow-up magnetic resonance imaging (MRI) and fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) revealed a solitary FDG-avid osteolytic lesion in the 4th cervical vertebral body without other abnormal FDG-uptake in the body and in the absence of local recurrence at the resection cavity. Because of the sudden worsening situation and intractable neck pain, the patient underwent tumor resection. Postoperatively, the pain was obviously reduced and the situation was improved. Interestingly, the immunohistochemical findings of glial fibrillary acidic protein (GFAP) indicated the characteristic of metastatic glioblastoma, despite that the histopathological findings of Hematoxylin & Eosin (H&E) staining was suspicious of osteoclastoma. According to the clinical history, imaging findings, pathological and immunohistochemical results, a final diagnosis of solitary vertebral metastasis from glioblastoma without central nervous system (CNS) relapse was confirmed. Then, the patient received radiotherapy on spine and adjuvant chemotherapy with temozolomide. However, he died suddenly 2 months after the tumor resection, nearly 21 months after the initial diagnosis. Conclusion: We emphasize that metastatic glioblastoma should be considered in the differential diagnosis of a solitary FDG-avid osteolytic vertebral mass on PET/CT. And the diagnosis of extracranial metastasis (ECM) from glioblastoma can be achieved through clinical history, imaging findings, pathological examination, and immunohistochemical staining with GFAP.

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Section: Discussionmentioning

confidence: 99%

Solitary vertebral metastatic glioblastoma in the absence of primary brain tumor relapse: a case report and literature review

Zheng

Zhao

et al. 2020

BMC Med Imaging

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“…Osteogenic sarcoma has an elevated rate of glycolysis and, consequently, a high uptake of 18 F-FDG in malignant cells [39] . A previous meta-analysis [40] revealed that the standardized uptake values before (SUV1) and after (SUV2) chemotherapy in osteosarcoma were associated with the histological response.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of 18F-FDG PET/CT in the diagnosis and staging of osteosarcoma: a meta-analysis of 26 studies

2019

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Background Multiple trials have attempted to assess the diagnostic value of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) in osteosarcoma with results remaining inconclusive. This study aims to investigate the effectiveness of 18 F-FDG PET and PET/CT in the diagnosis, staging, recurrence and metastasis formation observations of osteosarcoma through systematic review followed by meta-analysis. Methods Three electronic databases, Medline/PubMed, Embase and the Cochrane Library were utilized in this study. Eligible studies that assessed the performance of 18 F-FDG PET/CT for the diagnosis, staging, restaging and recurrence monitoring of osteosarcoma were retrieved utilizing specific search criteria. After screening and diluting out the non-conforming articles, all relevant articles and their data were identified and extracted to calculate the summary metrics involving sensitivity, specificity, diagnostic odd ratio (DOR), and area under the curve (AUC) to determine the effectiveness of 18 F-FDG PET in diagnosing osteosarcoma clinically. Results Out of 1976 articles searched, twenty-six studies were identified that were viable. All data from these articles, utilized in the quantitative analyses, showed after meta-analysis that when utilizing 18 F-FDG PET or PET/CT it was better with a success rate of 90–100% for detecting primary lesions and distant metastases of patients with osteosarcoma. Similar results were also obtained for detecting lung and bone metastases in a subgroup analysis. Conclusions As such the investigation demonstrated that 18 F-FDG PET and PET/CT are very accurate for the diagnosis, staging and recurrence monitoring of osteosarcoma. 18 F-FDG-avid lesions should be further examined in osteosarcoma, especially for suspicious lung lesions.

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“…18 F-FDG PET can detect the elevated glucose metabolism of cells, which is widely used for differentiation between benign and malignant neoplasms. Malignant lesions tend to be 18 F-FDG avid, however, benign lesions generally show lower 18F-FDG avidity [7]. Choi et al reported that the mean SUVmax values in the benign rib lesions were 2.5 ± 1.1 [8].…”

Section: Discussionmentioning

confidence: 99%

Giant cavernous hemangioma of the eleventh rib

Huang

Ning

Pan

2019

J Cardiothorac Surg

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Background Cavernous hemangioma of the rib is extremely rare benign vascular tumor. It is difficult to diagnose in time because both invasive and noninvasive examinations usually fail to distinguish it from other tumors of the rib and other bones. Case presentation We described an asymptomatic 44-year-old woman with cavernous hemangioma of the rib that was incidentally discovered in the bathing. The tumor was completely resected by minithoracotomy through posterolateral incision. The pathological tissue was diagnosed as a cavernous hemangioma composed of thin-walled blood vessels and red blood cells. Conclusions We reported this case of giant cavernous hemangioma of the rib for its extremely rare occurrence. The preoperative diagnosis is a challenge both clinically and radiologically, and difficult to distinguish this tumor from other tumors of the rib or long bones.

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PET/CT in Benign and Malignant Musculoskeletal Tumors and Tumor-Like Conditions

Cited by 38 publications

References 36 publications

Solitary vertebral metastatic glioblastoma in the absence of primary brain tumor relapse: a case report and literature review

Solitary vertebral metastatic glioblastoma in the absence of primary brain tumor relapse: a case report and literature review

Effectiveness of 18F-FDG PET/CT in the diagnosis and staging of osteosarcoma: a meta-analysis of 26 studies

Giant cavernous hemangioma of the eleventh rib

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