Pet exposure in the family during pregnancy and risk for type 1 diabetes-The prospective ABIS study

Faresjö, Åshild Olsen; Ludvigsson, Johnny

doi:10.1111/pedi.12721

Cited by 2 publications

(1 citation statement)

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“…Indeed, multiple environmental factors shape the gut microbiome in the first years of life, including geography and household exposures such as pets and siblings (131,138). The ABIS study showed that exposure during pregnancy to cats and dogs conferred no increased risk of T1D, but hamsters did (139).…”

Section: The Gut -Microbiome and Diet The Gut Microbiomementioning

confidence: 99%

Environmental Determinants of Type 1 Diabetes: From Association to Proving Causality

2021

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The rising incidence of type 1 diabetes (T1D) cannot be ascribed to genetics alone, and causative environmental triggers and drivers must also be contributing. The prospective TEDDY study has provided the greatest contributions in modern time, by addressing misconceptions and refining the search strategy for the future. This review outlines the evidence to date to support the pathways from association to causality, across all stages of T1D (seroconversion to beta cell failure). We focus on infections and vaccinations; infant growth and childhood obesity; the gut microbiome and the lifestyle factors which cultivate it. Of these, the environmental determinants which have the most supporting evidence are enterovirus infection, rapid weight gain in early life, and the microbiome. We provide an infographic illustrating the key environmental determinants in T1D and their likelihood of effect. The next steps are to investigate these environmental triggers, ideally though gold-standard randomised controlled trials and further prospective studies, to help explore public health prevention strategies.

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Section: The Gut -Microbiome and Diet The Gut Microbiomementioning

confidence: 99%

Environmental Determinants of Type 1 Diabetes: From Association to Proving Causality

2021

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The Role of Gut Microbiota and Environmental Factors in Type 1 Diabetes Pathogenesis

et al. 2020

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Pet exposure in the family during pregnancy and risk for type 1 diabetes-The prospective ABIS study

Abstract: Exposure to hamster during pregnancy seems to increase the risk of T1D in the child. One possibility could be infection by virus hosted by the pet.

Cited by 2 publications

References 33 publications

Environmental Determinants of Type 1 Diabetes: From Association to Proving Causality

Environmental Determinants of Type 1 Diabetes: From Association to Proving Causality

The Role of Gut Microbiota and Environmental Factors in Type 1 Diabetes Pathogenesis

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