PET imaging of 5-HT
            <sub>1A</sub>
            receptor binding in patients with temporal lobe epilepsy

Toczek, Maria T.; Carson, Richard E.; Lang, Lixin; Ma, Yulong; Spanaki, Marianna V.; Der, Margaret; Fazilat, S.; Kopylev, Leonid; Herscovitch, Peter; Eckelman, William C.; Theodore, William H.

doi:10.1212/01.wnl.0000049930.93113.20

Cited by 226 publications

(120 citation statements)

References 47 publications

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“…In 12 patients with TLE, an initial PET study found lower [ 18 F]FCWAY V ipsilateral than contralateral to the epileptic focus in inferior medial and laterial temporal regions of patients; [ 18 F]FCWAY V was 29% lower in raphe and 34% lower in ipsilateral thalamic regions in TLE patients relative to healthy controls (52). The [ 18 F]FCWAY V mean asymmetry index was significantly greater than mean cerebral blood flow and mean glucose metabolism asymmetry index suggesting relatively specific reduction in 5-HT 1A receptor BP in temporal lobe epileptic focus.…”

Section: Discussionmentioning

confidence: 99%

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5-HT1A Receptor Binding in Temporal Lobe Epilepsy Patients With and Without Major Depression

Hasler

Bonwetsch

Giovacchini

et al. 2007

Biological Psychiatry

129

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Background-Major depressive disorder (MDD) is the most common comorbid psychiatric condition associated with temporal lobe epilepsy (TLE). Preclinical and clinical studies suggest that 5-HT 1A receptors play a role in the pathophysiology of both TLE and MDD. There is preliminary evidence for an association between decreased 5-HT 1A receptor binding in limbic brain areas and affective symptoms in TLE patients. The objective of this study was to compare 5-HT 1A receptor binding between TLE patients with and without MDD. For the first time, 5-HT 1A receptor binding was measured in a sample large enough to permit sensitive comparisons between TLE patients with and without comorbid MDD diagnosed by clinical and structured psychiatric interviews.

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Section: Discussionmentioning

confidence: 99%

“…Serotonininduced anticonvulsive effects were mediated specifically by hippocampal 5-HT 1A receptors (32). Patients with TLE have reduced 5-HT 1A receptor binding (52). The reductions in serotonin receptor binding were not limited to disease-specific brain regions, or explained by brain atrophy (19).…”

Section: Introductionmentioning

confidence: 99%

5-HT1A Receptor Binding in Temporal Lobe Epilepsy Patients With and Without Major Depression

Hasler

Bonwetsch

Giovacchini

et al. 2007

Biological Psychiatry

129

View full text Add to dashboard Cite

show abstract

“…Decreased 5-HT 1A receptor binding potential has been consistently found in multiple brain areas of patients with MDD (Drevets et al, 1999. This abnormality is not highly specific for MDD and has been found in patients with panic disorder and temporal lobe epilepsy (Toczek et al, 2003), and may explain the considerable comorbidity among these conditions. The lack of effect of selective serotonin reuptake inhibitor treatment and hydrocortisone challenge on 5-HT 1A receptors in recovered patients with MDD suggests state-independence of this abnormality (Bhagwagar et al, , 2004.…”

Section: Functional Imagingmentioning

confidence: 96%

Discovering Endophenotypes for Major Depression

Hasler

Drevets

Manji

et al. 2004

Neuropsychopharmacol

1,026

739

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The limited success of genetic studies of major depression has raised questions concerning the definition of genetically relevant phenotypes. This paper presents strategies to improve the phenotypic definition of major depression by proposing endophenotypes at two levels: First, dissecting the depressive phenotype into key components results in narrow definitions of putative psychopathological endophenotypes: mood bias toward negative emotions, impaired reward function, impaired learning and memory, neurovegetative signs, impaired diurnal variation, impaired executive cognitive function, psychomotor change, and increased stress sensitivity. A review of the recent literature on neurobiological and genetic findings associated with these components is given. Second, the most consistent heritable biological markers of major depression are proposed as biological endophenotypes for genetic studies: REM sleep abnormalities, functional and structural brain abnormalities, dysfunctions in serotonergic, catecholaminergic, hypothalamic-pituitary-adrenocortical axis, and CRH systems, and intracellular signal transduction endophenotypes. The associations among the psychopathological and biological endophenotypes are discussed with respect to specificity, temporal stability, heritability, familiality, and clinical and biological plausibility. Finally, the case is made for the development of a new classification system in order to reduce the heterogeneity of depression representing a major impediment to elucidating the genetic and neurobiological basis of this common, severe, and often life-threatening illness.

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“…6,7 The AEDs with established psychotropic effects (for example, carbamazepine, valproate, and lamotrigine) have been found to cause an increase in 5 hydroxytryptamine (5HT). 8 -10 The anticonvulsant protection of carbamazepine can be blocked with 5HT-depleting drugs in rats genetically prone to have seizures.…”

Section: Psychiatric Disordersmentioning

confidence: 99%

Use of Antiepileptic Drugs for Nonepileptic Conditions: Psychiatric Disorders and Chronic Pain

2007

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Summary: Antiepileptic drugs (AEDs) are commonly utilized for nonepileptic conditions, including various psychiatric disorders and pain syndromes. Evidence for their benefit in these nonepileptic conditions varies widely among different drugs, but there is, in general, a paucity of published multicenter randomized double-blind trials. Variable levels of evidence suggest that lamotrigine and the vagal nerve stimulator have antidepressant properties. Carbamazepine, valproate, lamotrigine, and oxcarbazepine appear to have mood stabilizing properties while gabapentin, pregabalin, and tiagabine have anxiolytic benefits. Barbiturates, topiramate, and possibly phenytoin may precipitate or exacerbate depression. Underlying depression and anxiety symptoms may be exacerbated by levetiracetam, while psychotic symptoms have rarely been reported with topiramate, levetiracetam, and zonisamide. Pregabalin, gabapentin, carbamazepine, and oxcarbazepine have been used to treat neuropathic pain such as postherpetic neuralgia, and diabetic polyneuropathy. Topiramate and divalproex sodium have utility in the prophylaxis or acute treatment of migraine. Further rigorous studies are needed to clarify the utility of AEDs in nonepileptic conditions.

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PET imaging of 5-HT _1A receptor binding in patients with temporal lobe epilepsy

Abstract: These findings support the hypothesis of reduced serotonin receptor binding in temporal lobe epileptic foci.

Cited by 226 publications

References 47 publications

5-HT1A Receptor Binding in Temporal Lobe Epilepsy Patients With and Without Major Depression

5-HT1A Receptor Binding in Temporal Lobe Epilepsy Patients With and Without Major Depression

Discovering Endophenotypes for Major Depression

Use of Antiepileptic Drugs for Nonepileptic Conditions: Psychiatric Disorders and Chronic Pain

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PET imaging of 5-HT 1A receptor binding in patients with temporal lobe epilepsy

Abstract: These findings support the hypothesis of reduced serotonin receptor binding in temporal lobe epileptic foci.

Cited by 226 publications

References 47 publications

5-HT1A Receptor Binding in Temporal Lobe Epilepsy Patients With and Without Major Depression

5-HT1A Receptor Binding in Temporal Lobe Epilepsy Patients With and Without Major Depression

Discovering Endophenotypes for Major Depression

Use of Antiepileptic Drugs for Nonepileptic Conditions: Psychiatric Disorders and Chronic Pain

Contact Info

Product

Resources

About

PET imaging of 5-HT _1A receptor binding in patients with temporal lobe epilepsy